Silver and Money in the Ancient Near East

This paper gives a general introduction on money in the ancient Near East, with focus on the role of silver and trust. Attention is paid to the rich documentation of the Old-Assyrian trade between the city of Assur in Northern Mesopotamia and Kanesh in Anatolia (20th-19th century BC), the developments in the use of gold and silver currency (uncoined money) in Babylonia between c. 2000 and the arrival of Alexander the Great in 331 BC. The perception of money and the measure of monetization of the society are key issues

SLC30A10 manganese transporter in the brain protects against deficits in motor function and dopaminergic neurotransmission under physiological conditions.

Loss-of-function mutations in SLC30A10 induce hereditary manganese (Mn)-induced neuromotor disease in humans. We previously identified SLC30A10 to be a critical Mn efflux transporter that controls physiological brain Mn levels by mediating hepatic and intestinal Mn excretion in adolescence/adulthood. Our studies also revealed that in adulthood, SLC30A10 in the brain regulates brain Mn levels when Mn excretion capacity is overwhelmed (e.g. after Mn exposure). But, the functional role of brain SLC30A10 under physiological conditions is unknown. We hypothesized that, under physiological conditions, brain SLC30A10 may modulate brain Mn levels and Mn neurotoxicity in early postnatal life because body Mn excretion capacity is reduced in this developmental stage. We discovered that Mn levels of pan-neuronal/glial Slc30a10 knockout mice were elevated in specific brain regions (thalamus) during specific stages of early postnatal development (postnatal day 21), but not in adulthood. Furthermore, adolescent or adult pan-neuronal/glial Slc30a10 knockouts exhibited neuromotor deficits. The neuromotor dysfunction of adult pan-neuronal/glial Slc30a10 knockouts was associated with a profound reduction in evoked striatal dopamine release without dopaminergic neurodegeneration or changes in striatal tissue dopamine levels. Put together, our results identify a critical physiological function of brain SLC30A10-SLC30A10 in the brain regulates Mn levels in specific brain regions and periods of early postnatal life, which protects against lasting deficits in neuromotor function and dopaminergic neurotransmission. These findings further suggest that a deficit in dopamine release may be a likely cause of early-life Mn-induced motor disease

Sources at the End of the Cuneiform Era

The aim of this article is to discuss several groups of sources which are of special interest regarding the question of Mesopotamian identities after 539 BCE, towards the end of the use of cuneiform writing. In this late period, several languages and scripts were in use in Mesopotamia; therefore, groups of Akkadian, Aramaic, Greek, and Sumerian texts are discussed. The scripts used are Aramaic letters, cuneiform, and the Greek alphabet. A scholar who is interested in late Mesopotamian identities needs to take all these documents into account. This article aims at giving a brief overview on available textual material and where to find it. The topics of these texts vary from administrative documents to highly literary texts. The authors discuss Aramaic inscriptions, legal and administrative cuneiform texts, the astronomical diaries, the Seleucid Uruk scholarly texts, the late Babylonian priestly literature, Emesal cult-songs from the Hellenistic period, the Graeco-Babyloniaca (clay tablets containing cuneiform and Greek), and finally Greek inscriptions from Mesopotamia.Peer reviewe

Money, Currency and Crisis:In Search of Trust, 2000 BC to AD 2000

Money is a core feature in all discussions of economic crisis, as is clear from the debates about the responses of the European Central Bank and the Federal Reserve Bank of the United States to the 2008 economic crisis. This volume explores the role of money in economic performance, and focuses on how monetary systems have affected economic crises for the last 4,000 years. Recent events have confirmed that money is only a useful tool in economic exchange if it is trusted, and this is a concept that this text explores in depth. The international panel of experts assembled here offers a long-range perspective, from ancient Assyria to modern societies in Europe, China and the US. This book will be of interest to students and researchers of economic history, and to anyone who seeks to understand the economic crises of recent decades, and place them in a wider historical context