Automatic Dimension Selection for a Non-negative Factorization Approach to Clustering Multiple Random Graphs

We consider a problem of grouping multiple graphs into several clusters using singular value thesholding and non-negative factorization. We derive a model selection information criterion to estimate the number of clusters. We demonstrate our approach using "Swimmer data set" as well as simulated data set, and compare its performance with two standard clustering algorithms.Comment: This paper has been withdrawn by the author due to a newer version with overlapping content

Is a Space Laundry Needed for Exploration?

Future human space exploration missions will lengthen to years, and keeping crews clothed without a huge resupply burden is an important consideration for habitation systems. A space laundry system could be the solution; however, the resources it uses must be accounted for and must win out over the very reliable practice of bringing along enough spare underwear. Through NASA's Logistics Reduction and Repurposing project, trade off studies have been conducted to compare current space clothing systems, life extension of that clothing, traditional water based clothes washing and other sanitizing techniques. The best clothing system of course depends on the mission and assumptions, but in general, analysis results indicate that washing clothes on space missions will start to pay off as mission durations push past a year

Measurement of gut permeability using fluorescent tracer agent technology

Abstract The healthy gut restricts macromolecular and bacterial movement across tight junctions, while increased intestinal permeability accompanies many intestinal disorders. Dual sugar absorption tests, which measure intestinal permeability in humans, present challenges. Therefore, we asked if enterally administered fluorescent tracers could ascertain mucosal integrity, because transcutaneous measurement of differentially absorbed molecules could enable specimen-free evaluation of permeability. We induced small bowel injury in rats using high- (15 mg/kg), intermediate- (10 mg/kg), and low- (5 mg/kg) dose indomethacin. Then, we compared urinary ratios of enterally administered fluorescent tracers MB-402 and MB-301 to urinary ratios of sugar tracers lactulose and rhamnose. We also tested the ability of transcutaneous sensors to measure the ratios of absorbed fluorophores. Urinary fluorophore and sugar ratios reflect gut injury in an indomethacin dose dependent manner. The fluorophores generated smooth curvilinear ratio trajectories with wide dynamic ranges. The more chaotic sugar ratios had narrower dynamic ranges. Fluorophore ratios measured through the skin distinguished indomethacin-challenged from same day control rats. Enterally administered fluorophores can identify intestinal injury in a rat model. Fluorophore ratios are measureable through the skin, obviating drawbacks of dual sugar absorption tests. Pending validation, this technology should be considered for human use

Alssat Development Status and Its Applications in Trade Studies

The development of the Advanced Life Support (ALS) Sizing Analysis Tool (ALSSAT) using Microsoft Excel was initiated by the Crew and Thermal Systems Division (CTSD) of Johnson Space Center (JSC) in 1997 to support the ALS and Exploration Offices in Environmental Control and Life Support System (ECLSS) design and studies. It aids the user in performing detailed sizing of the ECLSS based on suggested default values or user inputs for different combinations of the ALS regenerative system technologies (Ref. 1, 2). This analysis tool will assist the user in performing ECLSS preliminary design and trade studies as well as system optimization efficiently and economically. Since ALSSAT's latest publication in ICES 2001 (Ref. 1) describing the development of ALSSAT with its Air Revitalization Subsystem (ARS), Water Management Subsystem (WMS), and Biomass Subsystem (Biomass) mass balance sheets, ALSSAT has been expanded to include mass balance and sizing models for the remaining three ALS subsystems, namely, the Solid Waste Management Subsystem (SWMS), the Food Management Subsystem (FMS), and the Thermal Control Subsystem (TCS). The external interfaces, including the Extravehicular Activities (EVA) and Human Accommodations (HA), were implemented into ALSSAT in 2002. The overall mass balance sheet, which integrates the six ALS subsystems and the external interfaces applicable to the ECLSS, was also developed. In 2003, ALSSAT was upgraded to include the consideration of redundancy and contingency options in the ECLSS, as well as more ALS regenerative technology selections. ALSSAT has been used for the Metric Calculation for FY02 and FY03 (Ref. 3). Several trade studies were conducted in 2003. The analytical results will be presented in this paper

Monotone Optimal Policies for a Transient Queueing Staffing Problem

We consider the problem of determining the optimal policy for staffing a queueing system over multiple periods, using a model that takes into account transient queueing effects. Formulating the problem in a dynamic programming setting, we show that the optimal policy follows a monotone optimal control by establishing the submodularity of the objective function with respect to the staffing level and initial queue size in a period. In particular, this requires proving that the system occupancy in a G/M/s queue is submodular in the number of servers and initial system occupancy

Derivation of gravity wave intrinsic parameters and vertical wavelength using a single scanning OH(3-1) airglow spectrometer

For the first time, we present an approach to derive zonal, meridional, and vertical wavelengths as well as periods of gravity waves based on only one OH* spectrometer, addressing one vibrational-rotational transition. Knowledge of these parameters is a precondition for the calculation of further information, such as the wave group velocity vector. OH(3-1) spectrometer measurements allow the analysis of gravity wave ground-based periods but spatial information cannot necessarily be deduced. We use a scanning spectrometer and harmonic analysis to derive horizontal wavelengths at the mesopause altitude above Oberpfaffenhofen (48.09∘ N, 11.28∘ E), Germany for 22 nights in 2015. Based on the approximation of the dispersion relation for gravity waves of low and medium frequencies and additional horizontal wind information, we calculate vertical wavelengths. The mesopause wind measurements nearest to Oberpfaffenhofen are conducted at Collm (51.30∘ N, 13.02∘ E), Germany, ca. 380 km northeast of Oberpfaffenhofen, by a meteor radar. In order to compare our results, vertical temperature profiles of TIMED-SABER (thermosphere ionosphere mesosphere energetics dynamics, sounding of the atmosphere using broadband emission radiometry) overpasses are analysed with respect to the dominating vertical wavelength

Physician decision making in selection of second-line treatments in immune thrombocytopenia in children.

Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder which presents with isolated thrombocytopenia and risk of hemorrhage. While most children with ITP promptly recover with or without drug therapy, ITP is persistent or chronic in others. When needed, how to select second-line therapies is not clear. ICON1, conducted within the Pediatric ITP Consortium of North America (ICON), is a prospective, observational, longitudinal cohort study of 120 children from 21 centers starting second-line treatments for ITP which examined treatment decisions. Treating physicians reported reasons for selecting therapies, ranking the top three. In a propensity weighted model, the most important factors were patient/parental preference (53%) and treatment-related factors: side effect profile (58%), long-term toxicity (54%), ease of administration (46%), possibility of remission (45%), and perceived efficacy (30%). Physician, health system, and clinical factors rarely influenced decision-making. Patient/parent preferences were selected as reasons more often in chronic ITP (85.7%) than in newly diagnosed (0%) or persistent ITP (14.3%, P = .003). Splenectomy and rituximab were chosen for the possibility of inducing long-term remission (P < .001). Oral agents, such as eltrombopag and immunosuppressants, were chosen for ease of administration and expected adherence (P < .001). Physicians chose rituximab in patients with lower expected adherence (P = .017). Treatment choice showed some physician and treatment center bias. This study illustrates the complexity and many factors involved in decision-making in selecting second-line ITP treatments, given the absence of comparative trials. It highlights shared decision-making and the need for well-conducted, comparative effectiveness studies to allow for informed discussion between patients and clinicians

Structure and functional reselection of the Mango-III fluorogenic RNA aptamer

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