The nature of assignment and non-assignment clauses

The purpose of this article is to examine the nature of assignment as it relates to contractual debts and contractual rights in general, before addressing problems presented by non-assignment clauses.1 The assignment of things in action sits precariously between contract law and property law and non-assignment clauses cannot properly be understood without an appreciation of this hybrid character of assignment.2 Non-assignment clauses pose the question whether and in what circumstances contractual rights are items of property. They also demand an examination of the doctrine of privity of contract and a response to the question whether one contracting party has the right unilaterally to vary the contract. Finally, non-assignment clauses set two primary values at odds with each other, namely freedom of contract and the free alienation of items of property. To a significant extent, the practical problems presented by non-assignment clauses will diminish when expected secondary legislation nullifying non-assignment clauses in the field of receivables (or book debts) comes into force,3 but some of the leading cases do not involve receivables and the subject therefore continues to merit attention for practical as well as for theoretical reasons

Good faith, the common law and the CISG

The author in this article deals with a significant point of irritation that affects the way that the civil law and the common law interact with each other and come together in the body of an international instrument such as the Convention on Contracts for the International Sale of Goods (CISG). The common law approaches legal rules at a significantly lower level of abstraction than the civil law and is uncomfortable with the type of general rules that appeals to the civil law mentality. The drive to codify the law in the civil law tradition creates a need for general clauses, such as those dealing with good faith. The common law views abstract statements of this kind as jeopardizing legal certainty. In the CISG, a compromise worked out in 1980 confined good faith to the interpretation of the CISG. No duty to act in good faith was imposed on the contracting parties. Nevertheless, good faith is commonly referred to in both respects in judicial decisions but in such a way as not to make it clear what good faith means or to show why there was any need to invoke it when the case could have been settled by other means

Towards Question-based Recommender Systems

Conversational and question-based recommender systems have gained increasing attention in recent years, with users enabled to converse with the system and better control recommendations. Nevertheless, research in the field is still limited, compared to traditional recommender systems. In this work, we propose a novel Question-based recommendation method, Qrec, to assist users to find items interactively, by answering automatically constructed and algorithmically chosen questions. Previous conversational recommender systems ask users to express their preferences over items or item facets. Our model, instead, asks users to express their preferences over descriptive item features. The model is first trained offline by a novel matrix factorization algorithm, and then iteratively updates the user and item latent factors online by a closed-form solution based on the user answers. Meanwhile, our model infers the underlying user belief and preferences over items to learn an optimal question-asking strategy by using Generalized Binary Search, so as to ask a sequence of questions to the user. Our experimental results demonstrate that our proposed matrix factorization model outperforms the traditional Probabilistic Matrix Factorization model. Further, our proposed Qrec model can greatly improve the performance of state-of-the-art baselines, and it is also effective in the case of cold-start user and item recommendations.Comment: accepted by SIGIR 202

LSST Science Book, Version 2.0

A survey that can cover the sky in optical bands over wide fields to faint magnitudes with a fast cadence will enable many of the exciting science opportunities of the next decade. The Large Synoptic Survey Telescope (LSST) will have an effective aperture of 6.7 meters and an imaging camera with field of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over 20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a total point-source depth of r~27.5. The LSST Science Book describes the basic parameters of the LSST hardware, software, and observing plans. The book discusses educational and outreach opportunities, then goes on to describe a broad range of science that LSST will revolutionize: mapping the inner and outer Solar System, stellar populations in the Milky Way and nearby galaxies, the structure of the Milky Way disk and halo and other objects in the Local Volume, transient and variable objects both at low and high redshift, and the properties of normal and active galaxies at low and high redshift. It then turns to far-field cosmological topics, exploring properties of supernovae to z~1, strong and weak lensing, the large-scale distribution of galaxies and baryon oscillations, and how these different probes may be combined to constrain cosmological models and the physics of dark energy

Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins

As core components of the microRNA-induced silencing complex (miRISC), Argonaute (AGO) proteins interact with TNRC6 proteins, recruiting other effectors of translational repression/mRNA destabilization. Here, we show that LIMD1 coordinates the assembly of an AGO-TNRC6 containing miRISC complex by binding both proteins simultaneously at distinct interfaces. Phosphorylation of AGO2 at Ser 387 by Akt3 induces LIMD1 binding, which in turn enables AGO2 to interact with TNRC6A and downstream effector DDX6. Conservation of this serine in AGO1 and 4 indicates this mechanism may be a fundamental requirement for AGO function and miRISC assembly. Upon CRISPR-Cas9-mediated knockout of LIMD1, AGO2 miRNA-silencing function is lost and miRNA silencing becomes dependent on a complex formed by AGO3 and the LIMD1 family member WTIP. The switch to AGO3 utilization occurs due to the presence of a glutamic acid residue (E390) on the interaction interface, which allows AGO3 to bind to LIMD1, AJUBA, and WTIP irrespective of Akt signaling

Consensus Guidelines for Advancing Coral Holobiont Genome and Specimen Voucher Deposition

Coral research is being ushered into the genomic era. To fully capitalize on the potential discoveries from this genomic revolution, the rapidly increasing number of high-quality genomes requires effective pairing with rigorous taxonomic characterizations of specimens and the contextualization of their ecological relevance. However, to date there is no formal framework that genomicists, taxonomists, and coral scientists can collectively use to systematically acquire and link these data. Spurred by the recently announced “Coral symbiosis sensitivity to environmental change hub” under the “Aquatic Symbiosis Genomics Project” - a collaboration between the Wellcome Sanger Institute and the Gordon and Betty Moore Foundation to generate gold-standard genome sequences for coral animal hosts and their associated Symbiodiniaceae microalgae (among the sequencing of many other symbiotic aquatic species) - we outline consensus guidelines to reconcile different types of data. The metaorganism nature of the coral holobiont provides a particular challenge in this context and is a key factor to consider for developing a framework to consolidate genomic, taxonomic, and ecological (meta)data. Ideally, genomic data should be accompanied by taxonomic references, i.e., skeletal vouchers as formal morphological references for corals and strain specimens in the case of microalgal and bacterial symbionts (cultured isolates). However, exhaustive taxonomic characterization of all coral holobiont member species is currently not feasible simply because we do not have a comprehensive understanding of all the organisms that constitute the coral holobiont. Nevertheless, guidelines on minimal, recommended, and ideal-case descriptions for the major coral holobiont constituents (coral animal, Symbiodiniaceae microalgae, and prokaryotes) will undoubtedly help in future referencing and will facilitate comparative studies. We hope that the guidelines outlined here, which we will adhere to as part of the Aquatic Symbiosis Genomics Project sub-hub focused on coral symbioses, will be useful to a broader community and their implementation will facilitate cross- and meta-data comparisons and analyses.CV acknowledges funding from the German Research Foundation (DFG), grants 433042944 and 458901010. Open Access publication fees are covered by an institutional agreement of the University of Konstanz

The Astropy Problem

The Astropy Project (http://astropy.org) is, in its own words, "a community effort to develop a single core package for Astronomy in Python and foster interoperability between Python astronomy packages." For five years this project has been managed, written, and operated as a grassroots, self-organized, almost entirely volunteer effort while the software is used by the majority of the astronomical community. Despite this, the project has always been and remains to this day effectively unfunded. Further, contributors receive little or no formal recognition for creating and supporting what is now critical software. This paper explores the problem in detail, outlines possible solutions to correct this, and presents a few suggestions on how to address the sustainability of general purpose astronomical software

Variable geometries of connection: Urban digital divides and the uses of Information Technology

This paper proposes a new way of conceptualising urban ‘digital divides’. It focuses on the ways in which Information and Communication Technologies (ICTs) unevenly affect the pace of life within the urban environment. Based on a detailed case study of how ICT s are being used in an affluent and a marginalised neighbourhood in Newcastle-upon-Tyne, the paper suggests that urban digital divides need to be understood as more than uneven patterns of access. They emerge in this work as more than the presence or absence of specific technological artefacts. Rather, it is argued that different styles and speeds of technologically mediated life now work to define urban socio-spatial inequalities. The paper distinguishes between two such key styles and speeds. First, the paper argues that affluent and professional groups now use new media technologies pervasively and continuously as the ‘background’ infrastructure to sustain privileged and intensely distanciated, but time-stressed, lifestyles. Second, more marginalised neighbourhoods tend to be characterised by instrumental and episodic ICT usage patterns which are often collectively organised through strong neighbourhood ties. For the former, mediated networks help orchestrate neighbourhood ties; for the latter it is those neighbourhood ties that enable online access