The influence of self-citation corrections on Egghe's g index

The g index was introduced by Leo Egghe as an improvement of Hirsch's index h for measuring the overall citation record of a set of articles. It better takes into account the highly skewed frequency distribution of citations than the h index. I propose to sharpen this g index by excluding the self-citations. I have worked out nine practical cases in physics and compare the h and g values with and without self-citations. As expected, the g index characterizes the data set better than the h index. The influence of the self-citations appears to be more significant for the g index than for the h index.Comment: 9 pages, 2 figures, submitted to Scientometric

Phase Transitions from Saddles of the Potential Energy Landscape

The relation between saddle points of the potential of a classical many-particle system and the analyticity properties of its thermodynamic functions is studied. For finite systems, each saddle point is found to cause a nonanalyticity in the Boltzmann entropy, and the functional form of this nonanalytic term is derived. For large systems, the order of the nonanalytic term increases unboundedly, leading to an increasing differentiability of the entropy. Analyzing the contribution of the saddle points to the density of states in the thermodynamic limit, our results provide an explanation of how, and under which circumstances, saddle points of the potential energy landscape may (or may not) be at the origin of a phase transition in the thermodynamic limit. As an application, the puzzling observations by Risau-Gusman et al. on topological signatures of the spherical model are elucidated.Comment: 5 pages, no figure

Monte-Carlo Simulations of the Dynamical Behavior of the Coulomb Glass

We study the dynamical behavior of disordered many-particle systems with long-range Coulomb interactions by means of damage-spreading simulations. In this type of Monte-Carlo simulations one investigates the time evolution of the damage, i.e. the difference of the occupation numbers of two systems, subjected to the same thermal noise. We analyze the dependence of the damage on temperature and disorder strength. For zero disorder the spreading transition coincides with the equilibrium phase transition, whereas for finite disorder, we find evidence for a dynamical phase transition well below the transition temperature of the pure system.Comment: 10 pages RevTeX, 8 Postscript figure

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition.

Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer 'persister' cells. The persister cell pool constitutes a reservoir from which drug-resistant tumours may emerge. Targeting persister cells therefore presents a therapeutic opportunity to impede tumour relapse. We previously found that cancer cells in a high mesenchymal therapy-resistant cell state are dependent on the lipid hydroperoxidase GPX4 for survival. Here we show that a similar therapy-resistant cell state underlies the behaviour of persister cells derived from a wide range of cancers and drug treatments. Consequently, we demonstrate that persister cells acquire a dependency on GPX4. Loss of GPX4 function results in selective persister cell ferroptotic death in vitro and prevents tumour relapse in mice. These findings suggest that targeting of GPX4 may represent a therapeutic strategy to prevent acquired drug resistance

Two Coupled Harmonic Oscillators on Non-commutative Plane

We investigate a system of two coupled harmonic oscillators on the non-commutative plane \RR^2_{\theta} by requiring that the spatial coordinates do not commute. We show that the system can be diagonalized by a suitable transformation, i.e. a rotation with a mixing angle \alpha. The obtained eigenstates as well as the eigenvalues depend on the non-commutativity parameter \theta. Focusing on the ground state wave function before the transformation, we calculate the density matrix \rho_0(\theta) and find that its traces {\rm Tr}(\rho_{0}(\theta)) and {\rm Tr}(\rho_0^2(\theta)) are not affected by the non-commutativity. Evaluating the Wigner function on \RR^2_{\theta} confirms this. The uncertainty relation is explicitly determined and found to depend on \theta. For small values of \theta, the relation is shifted by a \theta^2 term, which can be interpreted as a quantum correction. The calculated entropy does not change with respect to the normal case. We consider the limits \alpha=1 and \alpha={\pi\over 2}. In first case, by identifying \theta to the squared magnetic length, one can recover basic features of the Hall system.Comment: 15 pages, 1 figur

Interaction between ionic lattices and superconducting condensates

The interaction of the ionic lattice with the superconducting condensate is treated in terms of the electrostatic force in superconductors. It is shown that this force is similar but not identical to the force suggested by the volume difference of the normal and superconducting states. The BCS theory shows larger deviations than the two-fluid model.Comment: 6 pages no figure

A Matrix Model for Bilayered Quantum Hall Systems

We develop a matrix model to describe bilayered quantum Hall fluids for a series of filling factors. Considering two coupling layers, and starting from a corresponding action, we construct its vacuum configuration at \nu=q_iK_{ij}^{-1}q_j, where K_{ij} is a 2\times 2 matrix and q_i is a vector. Our model allows us to reproduce several well-known wave functions. We show that the wave function \Psi_{(m,m,n)} constructed years ago by Yoshioka, MacDonald and Girvin for the fractional quantum Hall effect at filling factor {2\over m+n} and in particular \Psi_{(3,3,1)} at filling {1\over 2} can be obtained from our vacuum configuration. The unpolarized Halperin wave function and especially that for the fractional quantum Hall state at filling factor {2\over 5} can also be recovered from our approach. Generalization to more than 2 layers is straightforward.Comment: 14 pages, minor changes in introduction and references added, published in JP

Energy-level statistics at the metal-insulator transition in anisotropic systems

We study the three-dimensional Anderson model of localization with anisotropic hopping, i.e. weakly coupled chains and weakly coupled planes. In our extensive numerical study we identify and characterize the metal-insulator transition using energy-level statistics. The values of the critical disorder $W_c$ are consistent with results of previous studies, including the transfer-matrix method and multifractal analysis of the wave functions. $W_c$ decreases from its isotropic value with a power law as a function of anisotropy. Using high accuracy data for large system sizes we estimate the critical exponent $\nu=1.45\pm0.2$. This is in agreement with its value in the isotropic case and in other models of the orthogonal universality class. The critical level statistics which is independent of the system size at the transition changes from its isotropic form towards the Poisson statistics with increasing anisotropy.Comment: 22 pages, including 8 figures, revtex few typos corrected, added journal referenc

Critical role for interferon regulatory factor 3 (IRF-3) and IRF-7 in type i interferon-mediated control of murine norovirus replication

Human noroviruses (HuNoV) are the major cause of epidemic, nonbacterial gastroenteritis in the world. The short course of HuNoV-induced symptoms has implicated innate immunity in control of norovirus (NoV) infection. Studies using murine norovirus (MNV) confirm the importance of innate immune responses during NoV infection. Type I alpha and beta interferons (IFN-α/β) limit HuNoV replicon function, restrict MNV replication in cultured cells, and control MNV replication in vivo. Therefore, the cell types and transcription factors involved in antiviral immune responses and IFN-α/β-mediated control of NoV infection are important to define. We used mice with floxed alleles of the IFNAR1 chain of the IFN-α/β receptor to identify cells expressing lysozyme M or CD11c as cells that respond to IFN-α/β to restrict MNV replication in vivo. Furthermore, we show that the transcription factors IRF-3 and IRF-7 work in concert to initiate unique and overlapping antiviral responses to restrict MNV replication in vivo. IRF-3 and IRF-7 restrict MNV replication in both cultured macrophages and dendritic cells, are required for induction of IFN-α/β in macrophages but not dendritic cells, and are dispensable for the antiviral effects of IFN-α/β that block MNV replication. These studies suggest that expression of the IFN-α/β receptor on macrophages/neutrophils and dendritic cells, as well as of IRF-3 and IRF-7, is critical for innate immune responses to NoV infection