Digging Deeper into Hardin\u27s Pasture: The Complex Institutional Structure of The Tragedy of the Commons

The institutional and ecological structure of Hardin’s “tragedy of the commons” appears deceptively simple: the open-access pasture eventually will be overexploited and degraded unless (i) it is privatized, (ii) the government regulates access and use, or (iii) the users themselves impose a common-property regime to regulate their own access and use. In this paper, we argue that the institutional structure of the “Herder Problem” (as it is known to game theorists) is far more complicated than it is usually portrayed. Specifically, it is not just about the pasture. It is equally about the grass that grows on the pasture and the cattle that consume the grass. Even Elinor Ostrom — a scholar known for embracing complexity — presented an overly simplistic portrayal of Hardin’s open-access pasture when she described its governance system as a null set of institutions. A more careful assessment of the situation, employing Ostrom’s Social-Ecological System (SES) framework, broadens the focus from the res communes omnium pasture to incorporate the res nullius grass that grows upon it and the res private cattle grazing there. The “tragedy” arises from the combination and interactions of the resources and their governing institutions, not just from the absence of property in the pasture. If the grass was not subject to appropriation, the cattle were not privately owned, or if property- and contract-enforcement institutions supporting market exchange were absent, the “tragedy of the commons” probably would not arise regardless of the pasture’s open-access status

Digging Deeper into Hardin\u27s Pasture: The Complex Institutional Structure of The Tragedy of the Commons

The institutional and ecological structure of Hardin’s “tragedy of the commons” appears deceptively simple: the open-access pasture eventually will be overexploited and degraded unless (i) it is privatized, (ii) the government regulates access and use, or (iii) the users themselves impose a common-property regime to regulate their own access and use. In this paper, we argue that the institutional structure of the “Herder Problem” (as it is known to game theorists) is far more complicated than it is usually portrayed. Specifically, it is not just about the pasture. It is equally about the grass that grows on the pasture and the cattle that consume the grass. Even Elinor Ostrom — a scholar known for embracing complexity — presented an overly simplistic portrayal of Hardin’s open-access pasture when she described its governance system as a null set of institutions. A more careful assessment of the situation, employing Ostrom’s Social-Ecological System (SES) framework, broadens the focus from the res communes omnium pasture to incorporate the res nullius grass that grows upon it and the res private cattle grazing there. The “tragedy” arises from the combination and interactions of the resources and their governing institutions, not just from the absence of property in the pasture. If the grass was not subject to appropriation, the cattle were not privately owned, or if property- and contract-enforcement institutions supporting market exchange were absent, the “tragedy of the commons” probably would not arise regardless of the pasture’s open-access status

Coordinated regulation of Myc trans-activation targets by Polycomb and the Trithorax group protein Ash1

<p>Abstract</p> <p>Background</p> <p>The Myc oncoprotein is a transcriptional regulator whose function is essential for normal development. Myc is capable of binding to 10% of the mammalian genome, and it is unclear how a developing embryo controls the DNA binding of its abundant Myc proteins in order to avoid Myc's potential for inducing tumorigenesis.</p> <p>Results</p> <p>To identify chromatin binding proteins with a potential role in controlling Myc activity, we established a genetic assay for dMyc activity in <it>Drosophila</it>. We conducted a genome-wide screen using this assay, and identified the Trithorax Group protein Ash1 as a modifier of dMyc activity. Ash1 is a histone methyltransferase known for its role in opposing repression by Polycomb. Using RNAi in the embryo and Affymetrix microarrays, we show that <it>ash1 </it>RNAi causes the increased expression of many genes, suggesting that it is directly or indirectly required for repression in the embryo, in contrast to its known role in maintenance of activation. Many of these genes also respond similarly upon depletion of <it>Pc </it>and <it>pho </it>transcripts, as determined by concurrent microarray analysis of <it>Pc </it>and <it>pho </it>RNAi embryos, suggesting that the three are required for low levels of expression of a common set of targets. Further, many of these overlapping targets are also activated by Myc overexpression. We identify a second group of genes whose expression in the embryo requires Ash1, consistent with its previously established role in maintenance of activation. We find that this second group of Ash1 targets overlaps those activated by Myc and that ectopic Myc overcomes their requirement for Ash1.</p> <p>Conclusion</p> <p>Genetic, genomic and chromatin immunoprecipitation data suggest a model in which Pc, Ash1 and Pho are required to maintain a low level of expression of embryonic targets of activation by Myc, and that this occurs, directly or indirectly, by a combination of disparate chromatin modifications.</p

Global Alfven Eigenmodes in the H-1 heliac

Recent upgrades in H-1 power supplies have enabled the operation of the H-1 experiment at higher heating powers than previously attainable. A heating power scan in mixed hydrogen/helium plasmas reveals a change in mode activity with increasing heating power. At low power (<50 kW) modes with beta-induced Alfven eigenmode (BAE) frequency scaling are observed. At higher power modes consistent with an analysis of nonconventional Global Alfven Eigenmodes (GAEs) are observed, the subject of this work. We have computed the mode continuum, and identified GAE structures using the ideal MHD solver CKA and the gyrokinetic code EUTERPE. An analytic model for ICRH-heated minority ions is used to estimate the fast ion temperature from the hydrogen species. Linear growth rate scans using a local flux surface stability calculation, LGRO, are performed. These studies demonstrate growth from circulating particles whose speed is significantly less than the Alfven speed, and are resonant with the mode through harmonics of the Fourier decomposition of the strongly-shaped heliac magnetic field. They reveal drive is possible with a small, hot energetic tail of the hydrogen species. Local linear growth rate scans are also complemented with global calculations from CKA and EUTERPE. These qualitatively confirm the findings from the LGRO study, and show that the inclusion of finite Larmor radius effects can reduce the growth rate by a factor of three, but do not affect marginal stability. Finally, a study of damping of the global mode with the thermal plasma is conducted, computing continuum, and the damping arising from parallel electric fields. We find that continuum damping is of order 0.1% for the configuration studied. The inclusion of resistivity lifts the damping to 19%. Such large damping is consistent with experimental observations that in absence of drive the mode decays rapidly (~0.1 ms).Comment: 18 pages, 15 figures, submitted 07/04/2017 to Plasma Physics and Controlled Fusio

Investigating the terminology used to describe Ecstasy

Purpose – The purpose of this paper is to evaluate the changing use of language concerning the drug Ecstasy and their potential consequences over the last ten years. Design/methodology/approach – The research used metadata analysis of different resource types to assess the changing frequency with which the terms Ecstasy and MDMA occur. Findings – Since 2011 there has been an increase in the use of the term “MDMA” relative to “Ecstasy”. The prevalence of the term MDMA is higher than that of Ecstasy in both academic literature and web based information resources. This is also found in the public’s own use of the terms. The shift from one term to the other highlights the lack of uniformity in the way Ecstasy and MDMA are reported. This underlines the need for clarity and consistency in reporting this substance so that correct information is disseminated for use by the general public, law enforcement agencies and healthcare professionals. Originality/value – This paper establishes a time line for when the term MDMA began to be used which has not yet been reported on. It compares the relative frequency of the use of the terms Ecstasy and MDMA over time illustrating a change in use and language and whether Ecstasy is still an appropriate term to use

Evolution of the holozoan ribosome biogenesis regulon

<p>Abstract</p> <p>Background</p> <p>The ribosome biogenesis (RiBi) genes encode a highly-conserved eukaryotic set of nucleolar proteins involved in rRNA transcription, assembly, processing, and export from the nucleus. While the mode of regulation of this suite of genes has been studied in the yeast, <it>Saccharomyces cerevisiae</it>, how this gene set is coordinately regulated in the larger and more complex metazoan genomes is not understood.</p> <p>Results</p> <p>Here we present genome-wide analyses indicating that a distinct mode of RiBi regulation co-evolved with the E(CG)-binding, Myc:Max bHLH heterodimer complex in a stem-holozoan, the ancestor of both Metazoa and Choanoflagellata, the protozoan group most closely related to animals. These results show that this mode of regulation, characterized by an E(CG)-bearing core-promoter, is specific to almost all of the known genes involved in ribosome biogenesis in these genomes. Interestingly, this holozoan RiBi promoter signature is absent in nematode genomes, which have not only secondarily lost Myc but are marked by invariant cell lineages typically producing small body plans of 1000 somatic cells. Furthermore, a detailed analysis of 10 fungal genomes shows that this holozoan signature in RiBi genes is not found in hemiascomycete fungi, which evolved their own unique regulatory signature for the RiBi regulon.</p> <p>Conclusion</p> <p>These results indicate that a Myc regulon, which is activated in proliferating cells during normal development as well as during tumor progression, has primordial roots in the evolution of an inducible growth regime in a protozoan ancestor of animals. Furthermore, by comparing divergent bHLH repertoires, we conclude that regulation by Myc but not by other bHLH genes is responsible for the evolutionary maintenance of E(CG) sites across the RiBi suite of genes.</p

Reconstructing Civility after Wrongdoing: A Place for Restorative Justice

Demonstration of mediation techniques that offer an alternative to retributive justice responses to wrongdoing

Luminescence complementation technology for the identification of MYC:TRRAP inhibitors

Mechanism-based targeted therapies have exhibited remarkable success in treating otherwise untreatable or unresectable cancers. Novel targeted therapies that correct dysregulated transcriptional programs in cancer are an unmet medical need. The transcription factor MYC is the most frequently amplified gene in human cancer and is overexpressed because of mutations in an array of oncogenic signaling pathways. The fact that many cancer cells cannot survive without MYC - a phenomenon termed MYC addiction - provides a compelling case for the development of MYC-specific targeted therapies. We propose a new strategy to inhibit MYC function by disrupting its essential interaction with TRRAP using small molecules. To achieve our goal, we developed a platform using luminescence complementation for identifying small molecules as inhibitors of the MYC:TRRAP interaction. Here we present validation of this assay by measuring the disruption of TRRAP binding caused by substitutions to the invariant and essential MYC homology 2 region of MYC