Turbulence and Accretion: a High-resolution Study of the B5 Filaments

High-resolution observations of the Perseus B5 "core" have previously revealed that this subsonic region actually consists of several filaments that are likely in the process of forming a quadruple stellar system. Since subsonic filaments are thought to be produced at the $\sim 0.1$ pc sonic scale by turbulent compression, a detailed kinematic study is crucial to test such a scenario in the context of core and star formation. Here we present a detailed kinematic follow-up study of the B5 filaments at a 0.009 pc resolution using the VLA and GBT combined observations fitted with multi-component spectral models. Using precisely identified filament spines, we find a remarkable resemblance between the averaged width profiles of each filament and Plummer-like functions, with filaments possessing FWHM widths of $\sim 0.03$ pc. The velocity dispersion profiles of the filaments also show decreasing trends towards the filament spines. Moreover, the velocity gradient field in B5 appears to be locally well ordered ($\sim 0.04$ pc) but globally complex, with kinematic behaviors suggestive of inhomogeneous turbulent accretion onto filaments and longitudinal flows towards a local overdensity along one of the filaments.Comment: 27 pages, 12 figures, published in The Astrophysical Journa

Ruthenium Sensitizer with Thienothiophene-Linked Carbazole Antennas in Conjunction with Liquid Electrolytes for Dye-Sensitized Solar Cells

A new heteroleptic ruthenium complex, coded CYC-B12, incorporating an antenna ligand composed of sequential connections of a thienothiophene conjugated bridge and carbazole hole-transport moiety was prepared. This new sensitizer exhibits a lower energy MLCT band centered at 555 nm with a high molar absorption coefficient of 2.24 x 10(4) M-1 cm(-1). The device sensitized by CYC-B12 in conjunction with a volatile electrolyte shows a high photovoltaic efficiency of 9.4% under an illumination of standard global AM 1.5G sunlight. With a low-volatile electrolyte, the cell based on this new sensitizer shows not only a good conversion efficiency of 8.2% but also excellent durability (>96%) under light soaking at 60 degrees C in a simulated sunlight for 1000 h. The difference in the electron recombination kinetics caused by various liquid electrolytes or aging process is also investigated by employing the transient photoelectrical measurements

The Green Bank Ammonia Survey (GAS): First Results of NH3 mapping the Gould Belt

We present an overview of the first data release (DR1) and first-look science from the Green Bank Ammonia Survey (GAS). GAS is a Large Program at the Green Bank Telescope to map all Gould Belt star-forming regions with $A_V \gtrsim 7$ mag visible from the northern hemisphere in emission from NH$_3$ and other key molecular tracers. This first release includes the data for four regions in Gould Belt clouds: B18 in Taurus, NGC 1333 in Perseus, L1688 in Ophiuchus, and Orion A North in Orion. We compare the NH$_3$ emission to dust continuum emission from Herschel, and find that the two tracers correspond closely. NH$_3$ is present in over 60\% of lines-of-sight with $A_V \gtrsim 7$ mag in three of the four DR1 regions, in agreement with expectations from previous observations. The sole exception is B18, where NH$_3$ is detected toward ~ 40\% of lines-of-sight with $A_V \gtrsim 7$ mag. Moreover, we find that the NH$_3$ emission is generally extended beyond the typical 0.1 pc length scales of dense cores. We produce maps of the gas kinematics, temperature, and NH$_3$ column densities through forward modeling of the hyperfine structure of the NH$_3$ (1,1) and (2,2) lines. We show that the NH$_3$ velocity dispersion, ${\sigma}_v$, and gas kinetic temperature, $T_K$, vary systematically between the regions included in this release, with an increase in both the mean value and spread of ${\sigma}_v$ and $T_K$ with increasing star formation activity. The data presented in this paper are publicly available.Comment: 33 pages, 27 figures, accepted to ApJS. Datasets are publicly available: https://dataverse.harvard.edu/dataverse/GAS_DR

Droplets I: Pressure-Dominated Sub-0.1 pc Coherent Structures in L1688 and B18

We present the observation and analysis of newly discovered coherent structures in the L1688 region of Ophiuchus and the B18 region of Taurus. Using data from the Green Bank Ammonia Survey (GAS), we identify regions of high density and near-constant, almost-thermal, velocity dispersion. Eighteen coherent structures are revealed, twelve in L1688 and six in B18, each of which shows a sharp "transition to coherence" in velocity dispersion around its periphery. The identification of these structures provides a chance to study the coherent structures in molecular clouds statistically. The identified coherent structures have a typical radius of 0.04 pc and a typical mass of 0.4 Msun, generally smaller than previously known coherent cores identified by Goodman et al. (1998), Caselli et al. (2002), and Pineda et al. (2010). We call these structures "droplets." We find that unlike previously known coherent cores, these structures are not virially bound by self-gravity and are instead predominantly confined by ambient pressure. The droplets have density profiles shallower than a critical Bonnor-Ebert sphere, and they have a velocity (VLSR) distribution consistent with the dense gas motions traced by NH3 emission. These results point to a potential formation mechanism through pressure compression and turbulent processes in the dense gas. We present a comparison with a magnetohydrodynamic simulation of a star-forming region, and we speculate on the relationship of droplets with larger, gravitationally bound coherent cores, as well as on the role that droplets and other coherent structures play in the star formation process.Comment: Accepted by ApJ in April, 201

Preclinical Evidence for the Use of Sunitinib Malate in the Treatment of Plexiform Neurofibromas

Plexiform neurofibromas (pNF) are pathognomonic nerve and soft tissue tumors of neurofibromatosis type I (NF1), which are highly resistant to conventional chemotherapy and associated with significant morbidity/mortality. Disruption of aberrant SCF/c-Kit signaling emanating from the pNF microenvironment induced the first ever objective therapeutic responses in a recent phase 2 trial. Sunitinib malate is a potent, highly selective RTK inhibitor with activity against c-Kit, PDGFR, and VEGFR, which have also been implicated in the pathogenesis of these lesions. Here, we evaluate the efficacy of sunitinib malate in a preclinical Krox20;Nf1flox/− pNF murine model. Experimental Design Proliferation, β-hexosaminidase release (degranulation), and Erk1/2 phosphorylation were assessed in sunitinib treated Nf1+/− mast cells and fibroblasts, respectively. Krox20;Nf1flox/− mice with established pNF were treated sunitinib or PBS-vehicle control for a duration of 12 weeks. pNF metabolic activity was monitored by serial [18F]DG-PET/CT imaging. Results Sunitinib suppressed multiple in vitro gain-in-functions of Nf1+/− mast cells and fibroblasts and attenuated Erk1/2 phosphorylation. Sunitinib treated Krox20;Nf1flox/− mice exhibited significant reductions in pNF size, tumor number, and FDG uptake compared to control mice. Histopathology revealed reduced tumor cellularity and infiltrating mast cells, markedly diminished collagen deposition, and increased cellular apoptosis in sunitinib treated pNF. Conclusions Collectively, these results demonstrate the efficacy of sunitinib in reducing tumor burden in Krox20;Nf1flox/− mice. These preclinical findings demonstrate the utility of inhibiting multiple RTKs in pNF and provide insights into the design of future clinical trials

A Resonant Lorentz-Force Magnetometer Exploiting Blue Sideband Actuation to Enhance Sensitivity and Resolution

This paper reports a miniaturized resonant Lorentz-force magnetometer that exploits blue-sideband actuation to attain a better sensitivity and resolution. The resonant magnetometer consists of a double-ended tuning fork (DETF) resonator with cavity slots to optimize thermoelastic dissipation, as well as a Lorentz-force generator structure to transduce the magnetic force to the axial of the resonator. The proposed device demonstrates a Lorentz-force sensitivity of 5.5 mV/nN, a noise floor of 1.25 μV/ √ Hz, and a resolution of 0.23 pN/ √ Hz. In comparison with a conventional drive scheme, the blue- sideband actuation achieves approximately two orders of magnitude improvement regarding sensitivity and resolution than that of the amplitude modulation (AM) readout and 3.6-fold enhancement than that of the frequency modulation (FM) readout. The results affirm the merit of the novel excitation method and provide solid evidence of its effectiveness in practical applications

Ubiquitous NH3\rm NH_3 supersonic component in L1688 coherent cores

Context : Star formation takes place in cold dense cores in molecular clouds. Earlier observations have found that dense cores exhibit subsonic non-thermal velocity dispersions. In contrast, CO observations show that the ambient large-scale cloud is warmer and has supersonic velocity dispersions. Aims : We aim to study the ammonia ($\rm NH_3$) molecular line profiles with exquisite sensitivity towards the coherent cores in L1688 in order to study their kinematical properties in unprecedented detail. Methods : We used $\rm NH_3$ (1,1) and (2,2) data from the first data release (DR1) in the Green Bank Ammonia Survey (GAS). We first smoothed the data to a larger beam of 1' to obtain substantially more extended maps of velocity dispersion and kinetic temperature, compared to the DR1 maps. We then identified the coherent cores in the cloud and analysed the averaged line profiles towards the cores. Results : For the first time, we detected a faint (mean $\rm NH_3$(1,1) peak brightness $<$0.25 K in $T_{MB}$), supersonic component towards all the coherent cores in L1688. We fitted two components, one broad and one narrow, and derived the kinetic temperature and velocity dispersion of each component. The broad components towards all cores have supersonic linewidths ($\mathcal{M}_S \ge 1$). This component biases the estimate of the narrow dense core component's velocity dispersion by $\approx$28% and the kinetic temperature by $\approx$10%, on average, as compared to the results from single-component fits. Conclusions : Neglecting this ubiquitous presence of a broad component towards all coherent cores causes the typical single-component fit to overestimate the temperature and velocity dispersion. This affects the derived detailed physical structure and stability of the cores estimated from $\rm NH_3$ observations.Comment: Accepted for publication in Astronomy & Astrophysics on 06/07/2020. 15 pages, 16 figures, 1 table. Language edits from previous versio

Smokeless Tobacco Use and the Risk of Head and Neck Cancer: Pooled Analysis of US Studies in the INHANCE Consortium

Previous studies on smokeless tobacco use and head and neck cancer (HNC) have found inconsistent and often imprecise estimates, with limited control for cigarette smoking. Using pooled data from 11 US case-control studies (1981–2006) of oral, pharyngeal, and laryngeal cancers (6,772 cases and 8,375 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium, we applied hierarchical logistic regression to estimate odds ratios and 95% confidence intervals for ever use, frequency of use, and duration of use of snuff and chewing tobacco separately for never and ever cigarette smokers. Ever use (versus never use) of snuff was strongly associated with HNC among never cigarette smokers (odds ratio (OR) = 1.71, 95% confidence interval (CI): 1.08, 2.70), particularly for oral cavity cancers (OR = 3.01, 95% CI: 1.63, 5.55). Although ever (versus never) tobacco chewing was weakly associated with HNC among never cigarette smokers (OR = 1.20, 95% CI: 0.81, 1.77), analyses restricted to cancers of the oral cavity showed a stronger association (OR = 1.81, 95% CI: 1.04, 3.17). Few or no associations between each type of smokeless tobacco and HNC were observed among ever cigarette smokers, possibly reflecting residual confounding by smoking. Smokeless tobacco use appears to be associated with HNC, especially oral cancers, with snuff being more strongly associated than chewing tobacco