Putting Practice into Theory: Reconciling Academic Discourse with Experience

This paper is based on our work with experienced professionals in the Practitioner in Residence (PIR) Program. The program allows an experienced urban practitioner to undertake a period of supported research in residence at the University of Sydney under the auspices of the Henry Halloran Trust. The aim is to enable professionals to impart their knowledge to other urban professionals and thereby inform their practice. The PIR writes from experience on a topic of concern, relating it to the literature in the field and arguing the case for change. Our PIRs bring experience to the project and, under guidance derive a principle/s that can speak to other practitioners in a well researched and grounded argument. Outside the institutional constraint of their office PIRs are able to bring the wisdom of experience to discussing the politics and pragmatics that contend with planning goals. The program is part of a broader Trust agenda to better connect Australian urban planning practice to the evidence base within urban planning research. Through the program we hope to produce research outputs relevant and accessible to practitioners. The paper discusses the dynamics of the PIR program, the necessary links between theory and practice and the problems of relevance and accessibility of planning research. Keywords: action research, research led practic

Emergency Department Repair of Blunt Right Atrial Rupture Utilizing Cardiopulmonary Bypass

Blunt cardiac injury (BCI) with free wall rupture carries a high risk of pre-hospital death. Cardiopulmonary bypass (CPB) has been utilized as a bridge to repair of cardiac lesions in select patients. We present an interesting case of emergency department repair of right atrial rupture with cardiopulmonary bypass

Survival and Home Range Estimates of Pen-Raised Northern Bobwhites in Buffer Strip and Non-Buffer Strip Habitats

We investigated the effect of agricultural buffer strips on survival and home range estimates of pen-raised northern bobwhites (Colinus virginianus) at Tudor Farms on the Eastern Shore of Maryland. In September 2000 we released groups of bobwhites into 9 buffer strip (treatment) areas and 9 non-buffer strip (control) areas among 11 agricultural farms. Each group consisted of 4 radiomarked bobwhites and 26 non-radiomarked bobwhites. To maintain contact with the established coveys, additional radiomarked bobwhites (n = 177) were introduced into the coveys as radiomarked birds died. Survival for bobwhites released in buffer strip areas was lower (P \u3c 0.001) than survival in non-buffer strip areas. None of the radiomarked bobwhites released in the buffer strip areas survived past 27 weeks, whereas 11% of radiomarked bobwhites in non-buffer strip areas survived to 27 weeks and 1 bird survived to 41 weeks. Predation was the primary mortality factor (88%), followed by unknown causes (7%), stress (2%), hunting (2%), and road kill (1%). Mean fall and winter home range (95% minimum convex polygon) for 21 bobwhite coveys was 24.2 +- 3.5 ha, ranging from 1.7 to 65.8 ha. Home range areas of bobwhite coveys in buffer strips (n = 12, x¯ +- 15.0 2.7 ha) was significantly smaller (P = 0.002) than non-buffer strip coveys (n = 9, x¯ = 36.4 +- 4.9 ha). We conclude that the smaller home ranges in buffer strip areas seem to indicate better habitat quality; however, high mortality rates of pen-raised bobwhites limited our ability to confirm this

Mechanically transferred large-area Ga2_2O3_3 passivates graphene and suppresses interfacial phonon scattering

We demonstrate a large-area passivation layer for graphene by mechanical transfer of ultrathin amorphous Ga$_2$O$_3$ synthesized on liquid Ga metal. A comparison of temperature-dependent electrical measurements of millimetre-scale passivated and bare graphene on SiO$_2$/Si indicate that the passivated graphene maintains its high field effect mobility desirable for applications. Surprisingly, the temperature-dependent resistivity is reduced in passivated graphene over a range of temperatures below 220 K, due to the interplay of screening of the surface optical phonon modes of the SiO$_2$ by high-dielectric-constant Ga$_2$O$_3$, and the relatively high characteristic phonon frequencies of Ga$_2$O$_3$. Raman spectroscopy and electrical measurements indicate that Ga$_2$O$_3$ passivation also protects graphene from further processing such as plasma-enhanced atomic layer deposition of Al$_2$O$_3$.Comment: Journal article, 10 pages, 4 figure

KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation.

Kinase suppressor of Ras 2 (KSR2) is an intracellular scaffolding protein involved in multiple signaling pathways. Targeted deletion of Ksr2 leads to obesity in mice, suggesting a role in energy homeostasis. We explored the role of KSR2 in humans by sequencing 2,101 individuals with severe early-onset obesity and 1,536 controls. We identified multiple rare variants in KSR2 that disrupt signaling through the Raf-MEKERK pathway and impair cellular fatty acid oxidation and glucose oxidation in transfected cells; effects that can be ameliorated by the commonly prescribed antidiabetic drug, metformin. Mutation carriers exhibit hyperphagia in childhood, low heart rate, reduced basal metabolic rate and severe insulin resistance. These data establish KSR2 as an important regulator of energy intake, energy expenditure, and substrate utilization in humans. Modulation of KSR2-mediated effects may represent a novel therapeutic strategy for obesity and type 2 diabetes.This work was supported by the Wellcome Trust (098497/Z/12/Z; 077016/Z/05/Z; 096106/Z/11/Z) (ISF and LRP), Medical Research Council (MC_U106179471) (NW), NIHR Cambridge Biomedical Research Centre (ISF, IB and SOR), and European Research Council (ISF). This study makes use of data generated by the UK10K Consortium (WT091310). A full list of the investigators who contributed to the generation of the data is available from http://www.UK10K.org.This is the final published version. It first appeared at http://www.cell.com/abstract/S0092-8674%2813%2901276-2

Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity

A. Palotie on työryhmän UK10K Consortium jäsen.Obesity is a genetically heterogeneous disorder. Using targeted and whole-exome sequencing, we studied 32 human and 87 rodent obesity genes in 2,548 severely obese children and 1,117 controls. We identified 52 variants contributing to obesity in 2% of cases including multiple novel variants in GNAS, which were sometimes found with accelerated growth rather than short stature as described previously. Nominally significant associations were found for rare functional variants in BBS1, BBS9, GNAS, MKKS, CLOCK and ANGPTL6. The p.S284X variant in ANGPTL6 drives the association signal (rs201622589, MAF similar to 0.1%, odds ratio = 10.13, p-value = 0.042) and results in complete loss of secretion in cells. Further analysis including additional case-control studies and population controls (N = 260,642) did not support association of this variant with obesity (odds ratio = 2.34, p-value = 2.59 x 10(-3)), highlighting the challenges of testing rare variant associations and the need for very large sample sizes. Further validation in cohorts with severe obesity and engineering the variants in model organisms will be needed to explore whether human variants in ANGPTL6 and other genes that lead to obesity when deleted in mice, do contribute to obesity. Such studies may yield druggable targets for weight loss therapies.Peer reviewe

Optics and Quantum Electronics

Contains table of contents for Section 3, reports on twenty-one research projects and a list of publications and meeting papers.Joint Services Electronics Program Contract DAAL03-92-C-0001U.S. Air Force - Office of Scientific Research Contract F49620-91-C-0091Charles S. Draper Laboratories Contract DL-H-441692MIT Lincoln LaboratoryNational Science Foundation Grant ECS 90-12787Fujitsu LaboratoriesU.S. Navy - Office of Naval Research Grant N00014-92-J-1302National Center for Integrated Photonic TechnologyNational Science Foundation Grant ECS 85-52701U.S. Navy - Office of Naval Research (MFEL) Grant N00014-91-C-0084U.S. Navy - Office of Naval Research (MFEL) Grant N00014-91-J-1956National Institutes of Health Grant R01-GM35459-08U.S. Air Force - Office of Scientific Research Grant F49620-93-1-0301MIT Lincoln Laboratory Contract BX-5098Electric Power Research Institute Contract RP3170-2

Optics and Quantum Electronics

Contains table of contents for Section 3 and reports on twenty-three research projects.Joint Services Electronics Program Contract DAAL03-92-C-0001U.S. Air Force - Office of Scientific Research Contract F49620-91-C-0091Charles S. Draper Laboratories Contract DL-H-441629MIT Lincoln LaboratoryNational Science Foundation Grant ECS 90-12787Fujitsu LaboratoriesU.S. Navy - Office of Naval Research Grant N00014-92-J-1302National Center for Integrated PhotonicsNational Center for Integrated Photonics TechnologyNational Science Foundation Grant EET 88-15834Joint Services Electronics Program Contract DAAL03-91-C-0001National Science Foundation Fellowship ECS-85-52701U.S. Navy - Office of Naval Research (MGH) Contract N00014-91-C-0084U.S. Navy - Office of Naval Research Grant N00014-91-J-1956National Institutes of Health Grant NIH-5-RO1-GM35459-08Bose CorporationLawrence Livermore National Laboratories Subcontract B160530U.S. Department of Energy Grant DE-FG02-89-ER14012Rockwell International CorporationSpace Exploration AssociatesFuture Energy Applied Technology, Inc

Arsenic migration to deep groundwater in Bangladesh influenced by adsorption and water demand

Drinking shallow groundwater with naturally elevated concentrations of arsenic is causing widespread disease in many parts of South and Southeast Asia. In the Bengal Basin, growing reliance on deep (\u3e150 m) groundwater has lowered exposure. In the most affected districts of Bangladesh, shallow groundwater concentrations average 100 to 370 μg L−1, while deep groundwater is typically \u3c 10 μg L−1. Groundwater flow simulations have suggested that, even when deep pumping is restricted to domestic use, deep groundwater in some areas of the Bengal Basin is at risk of contamination. However, these simulations have neglected the impedance of As migration by adsorption to aquifer sediments. Here we quantify for the first time As sorption on deeper sediments in situ by replicating the intrusion of shallow groundwater through injection of 1,000 L of deep groundwater modified with 200 μg L−1 of As into a deeper aquifer. Arsenic concentrations in the injected water were reduced by 70% due to adsorption within a single day. Basin-scale modelling indicates that while As adsorption extends the sustainable use of deep groundwater, some areas remain vulnerable; these areas can be prioritized for management and monitoring