Empirical Tests of Intransitivity Predicted by Models of Risky Choice

Recently proposed models of risky choice imply systematic violations of transitivity of preference. Five studies explored whether people show patterns of intransitivity predicted by four descriptive models. To distinguish ?true? violations from those produced by ?error,? a model was fit in which each choice can have a different error rate and each person can have a different pattern of true preferences that need not be transitive. Error rate for a choice is estimated from preference reversals between repeated presentations of the same choice. Results of five studies showed that very few people repeated intransitive patterns. We can retain the hypothesis that transitivity best describes the data of the vast majority of participants. --decision making,errors,gambling effect,reference points,regret,transitivity

Testing Theories of Risky Decision Making Via Critical Tests

Whereas some people regard models of risky decision making as if they were statistical summaries of data collected for some other purpose, I think of models as theories that can be tested by experiments. I argue that comparing theories by means of global indices of fit is not a fruitful way to evaluate theories of risky decision making. I argue instead for experimental science. That is, test critical properties, which are theorems of one model that are violated by a rival model. Recent studies illustrate how conclusions based on fit can be overturned by critical tests. Elsewhere, I have warned against drawin

Medication adherence in schizophrenia: patient perspectives and the clinical utility of paliperidone ER

Antipsychotic medications provide the foundation for treatment of acute exacerbations as well as relapse prevention in patients with schizophrenia as demonstrated by rigorous placebo-controlled trials. However, despite their proven effectiveness, poor adherence to prescribed antipsychotic regimens remains the most important driver of suboptimal clinical outcomes in this population. This paper reviews the magnitude of the problem of medication non-adherence in patients with schizophrenia and the various factors that contribute to non-adherence, with particular emphasis on factors related to antipsychotic medications. The profile of the latest atypical antipsychotic, paliperidone extended-release (ER) tablets, is then reviewed and the implications of its unique pharmacokinetic profile for adherence in this patient population are discussed

Proposal to encode additional Cyrillic characters in the BMP of the UCS

This is a proposal to add several Cyrillic characters to the international character encoding standard Unicode. These additions were published in Unicode Standard version 5.1 in March 2008. This proposal includes characters used for various communities, including a number of non-Slavic minority languages (Mordvin, Kurdish, Aleut, Chuvash, and Abkhaz). It also includes additions for early Slavic philology and linguistics and for ecclesiastical works

IRA Propaganda on Twitter: Stoking Antagonism and Tweeting Local News

This paper presents preliminary findings of a content analysis of tweets posted by false accounts operated by the Internet Research Agency (IRA) in St Petersburg . We relied on a historical database of tweets to retrieve 4539 tweets posted by IRA-linked accounts in 2012-2017 and coded 2501 tweets manually . The messages cover US newsworthy events , the Charlie Hebdo terrorist attack in 2015, and the Brexit referendum in 2016. Tweets were annotated using 19 control variables to investigate whether IRA operations on social media are consistent with classic propaganda models. The results show that the IRA operates a composite of user account s tailored to perform specific tasks , with the lion’s share of their work focusing on US daily news activity and the diffusion of polarized news across different national contexts

Neurotransmitter modulation of extracellular H+ fluxes from isolated retinal horizontal cells of the skate

Self-referencing H+-selective microelectrodes were used to measure extracellular H+ fluxes from horizontal cells isolated from the skate retina. A standing H+ flux was detected from quiescent cells, indicating a higher concentration of free hydrogen ions near the extracellular surface of the cell as compared to the surrounding solution. The standing H+ flux was reduced by removal of extracellular sodium or application of 5-(N-ethyl-N-isopropyl) amiloride (EIPA), suggesting activity of a Na+–H+ exchanger. Glutamate decreased H+ flux, lowering the concentration of free hydrogen ions around the cell. AMPA/kainate receptor agonists mimicked the response, and the AMPA/kainate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) eliminated the effects of glutamate and kainate. Metabotropic glutamate agonists were without effect. Glutamate-induced alterations in H+ flux required extracellular calcium, and were abolished when cells were bathed in an alkaline Ringer solution. Increasing intracellular calcium by photolysis of the caged calcium compound NP-EGTA also altered extracellular H+ flux. Immunocytochemical localization of the plasmalemma Ca2+–H+-ATPase (PMCA pump) revealed intense labelling within the outer plexiform layer and on isolated horizontal cells. Our results suggest that glutamate modulation of H+ flux arises from calcium entry into cells with subsequent activation of the plasmalemma Ca2+–H+-ATPase. These neurotransmitter-induced changes in extracellular pH have the potential to play a modulatory role in synaptic processing in the outer retina. However, our findings argue against the hypothesis that hydrogen ions released by horizontal cells normally act as the inhibitory feedback neurotransmitter onto photoreceptor synaptic terminals to create the surround portion of the centre-surround receptive fields of retinal neuron