Topic-dependent sentiment analysis of financial blogs

While most work in sentiment analysis in the financial domain has focused on the use of content from traditional finance news, in this work we concentrate on more subjective sources of information, blogs. We aim to automatically determine the sentiment of financial bloggers towards companies and their stocks. To do this we develop a corpus of financial blogs, annotated with polarity of sentiment with respect to a number of companies. We conduct an analysis of the annotated corpus, from which we show there is a significant level of topic shift within this collection, and also illustrate the difficulty that human annotators have when annotating certain sentiment categories. To deal with the problem of topic shift within blog articles, we propose text extraction techniques to create topic-specific sub-documents, which we use to train a sentiment classifier. We show that such approaches provide a substantial improvement over full documentclassification and that word-based approaches perform better than sentence-based or paragraph-based approaches

Exploring the use of paragraph-level annotations for sentiment analysis of financial blogs

In this paper we describe our work in the area of topic-based sentiment analysis in the domain of financial blogs. We explore the use of paragraph-level and document-level annotations, examining how additional information from paragraph-level annotations can be used to increase the accuracy of document-level sentiment classification. We acknowledge the additional effort required to provide these paragraph-level annotations, and so we compare these findings against an automatic means of generating topic-specific sub-documents

Assessing awareness and attitudes of healthcare professionals on the use of biosimilar medicines: A survey of physicians and pharmacists in Ireland

Increasing numbers of biosimilar medicines are becoming available. The objective of this survey was to assess awareness of and attitudes to biosimilars amongst physicians (medical specialists and General Practitioners (GPs)) and community pharmacists in Ireland. Physicians were invited to complete an online questionnaire during April and May 2016. Community pharmacists received a postal questionnaire in August 2015. Responses from 102 medical specialists, 253 GPs and 125 community pharmacists were analysed. The majority of medical specialists (85%) and pharmacists (77%) claimed to be either very familiar or familiar with the term biosimilar, whereas many GPs (60%) were unable to define or had never heard of the term. One in five (21%) healthcare professionals responded that biosimilars were the same as generic medicines. The majority of medical specialists opposed pharmacist-led substitution of biological medicines but some thought it could be appropriate if agreed with the clinician in advance. Medical specialists who prescribe biosimilars (n = 43) were more likely to do so on treatment initiation (67%), than switch a patient from an originator medicine to a biosimilar (28%). The findings will aid the design of educational initiatives for healthcare professionals and highlight attitudes of healthcare professionals to biosimilars, so informing regulators, policy makers and industry

Regulatory Science Ireland: bridging the information gap on biosimilar medicines

Regulatory Science Ireland (RSI) is a voluntary network of interested parties from academia, the Health Products Regulatory Authority (HPRA), pharmaceutical and medical device industries and government agencies. RSI is conducting a research project, the objective of which is to enhance understanding of biosimilar medicines amongst stakeholders and encourage best practice in the use of these medicines

Knowledge of adverse drug reaction reporting and the pharmacovigilance of biological medicines: A survey of healthcare professionals in Ireland.

Background: In Europe, changes to pharmacovigilance legislation, which include additional monitoring of medicines, aim to optimise adverse drug reaction (ADR) reporting systems. The legislation also makes provisions related to the traceability of biological medicines. Objective: The objective of this study was to assess (i) knowledge and general experience of ADR reporting, (ii) knowledge, behaviours, and attitudes related to the pharmacovigilance of biologicals, and (iii) awareness of additional monitoring among healthcare professionals (HCPs) in Ireland. Methods: Hospital doctors (n = 88), general practitioners (GPs) (n = 197), nurses (n = 104) and pharmacists (n = 309) completed an online questionnaire. Results: There were differences in mean knowledge scores relating to ADR reporting and the pharmacovigilance of biologicals among the HCP groups. The majority of HCPs who use biological medicines in their practice generally record biologicals by brand name but practice behaviours relating to batch number recording differed between some professions. HCPs consider batch number recording to be valuable but also regard it as being more difficult than brand name recording. Most respondents were aware of the concept of additional monitoring but awareness rates differed between some groups. Among those who knew about additional monitoring, there was higher awareness of the inverted black triangle symbol among pharmacists (> 86.4%) compared with hospital doctors (35.1%), GPs (35.6%), and nurses (14.9%). Hospital pharmacists had more experience and knowledge of ADR reporting than other practising HCPs. Conclusion: This study highlights the important role hospital pharmacists play in post-marketing surveillance. There is a need to increase pharmacovigilance awareness of biological medicines and improve systems to support their batch traceability

Manufacturing of biocompatible porous titanium scaffolds using a novel spherical sugar pellet space holder

A new and highly biocompatible space holder material is proposed for manufacturing of porous titanium with open and interconnected pore morphologies through powder metallurgy techniques. Sugar pellets are compacted with titanium powder and then removed by dissolution in water before sintering. The morphology, pore structure and porosity were observed by optical microscopy, SEM and micro-CT. The porous titanium has highly spherical pore shapes, well-controlled pore sizes and high interconnectivity. The results suggest that porous titanium scaffolds generated using this manufacturing route have the potential for hard tissue engineering applications

Proprioceptor Pathway Development Is Dependent on MATH1

AbstractThe proprioceptive system provides continuous positional information on the limbs and body to the thalamus, cortex, pontine nucleus, and cerebellum. We showed previously that the basic helix-loop-helix transcription factor Math1 is essential for the development of certain components of the proprioceptive pathway, including inner-ear hair cells, cerebellar granule neurons, and the pontine nuclei. Here, we demonstrate that Math1 null embryos lack the D1 interneurons and that these interneurons give rise to a subset of proprioceptor interneurons and the spinocerebellar and cuneocerebellar tracts. We also identify three downstream genes of Math1 (Lh2A, Lh2B, and Barhl1) and establish that Math1 governs the development of multiple components of the proprioceptive pathway

Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage

The Sox10 transcription factor is required to maintain as well as specify glial identity, adding new causes for the neuropathies associated with SOX10 mutations