Continuously Crossing u=z in the H3+ Boundary CFT

For AdS boundary conditions, we give a solution of the H3+ two point function involving degenerate field with SL(2)-label b^{-2}/2, which is defined on the full (u,z) unit square. It consists of two patches, one for z<u and one for u<z. Along the u=z "singularity", the solutions from both patches are shown to have finite limits and are merged continuously as suggested by the work of Hosomichi and Ribault. From this two point function, we can derive b^{-2}/2-shift equations for AdS_2 D-branes. We show that discrete as well as continuous AdS_2 branes are consistent with our novel shift equations without any new restrictions.Comment: version to appear in JHEP - 12 pages now; sign error with impact on some parts of the interpretation fixed; material added to become more self-contained; role of bulk-boundary OPE in section 4 more carefully discussed; 3 references adde

Sorption of Ochratoxin A from Aqueous Solutions Using β-Cyclodextrin-Polyurethane Polymer

The ability of a cyclodextrin-polyurethane polymer to remove ochratoxin A from aqueous solutions was examined by batch rebinding assays. The results from the aqueous binding studies were fit to two parameter models to gain insight into the interaction of ochratoxin A with the nanosponge material. The ochratoxin A sorption data fit well to the heterogeneous Freundlich isotherm model. The polymer was less effective at binding ochratoxin A in high pH buffer (9.5) under conditions where ochratoxin A exists predominantly in the dianionic state. Batch rebinding assays in red wine indicate the polymer is able to remove significant levels of ochratoxin A from spiked solutions between 1–10 μg·L−1. These results suggest cyclodextrin nanosponge materials are suitable to reduce levels of ochratoxin A from spiked aqueous solutions and red wine samples

Monitoring Drought Conditions in the Navajo Nation Using NASA Earth Observations

The Navajo Nation, a 65,700 sq km Native American territory located in the southwestern United States, has been increasingly impacted by severe drought events and changes in climate. These events are coupled with a lack of domestic water infrastructure and economic resources, leaving approximately one-third of the population without access to potable water in their homes. Current methods of monitoring drought are dependent on state-based monthly Standardized Precipitation Index value maps calculated by the Western Regional Climate Center. However, these maps do not provide the spatial resolution needed to illustrate differences in drought severity across the vast Nation. To better understand and monitor drought events and drought regime changes in the Navajo Nation, this project created a geodatabase of historical climate information specific to the area, and a decision support tool to calculate average Standardized Precipitation Index values for user-specified areas. The tool and geodatabase use Tropical Rainfall Monitoring Mission (TRMM) and Global Precipitation Monitor (GPM) observed precipitation data and Parameter-elevation Relationships on Independent Slopes Model modeled historical precipitation data, as well as NASA's modeled Land Data Assimilation Systems deep soil moisture, evaporation, and transpiration data products. The geodatabase and decision support tool will allow resource managers in the Navajo Nation to utilize current and future NASA Earth observation data for increased decision-making capacity regarding future climate change impact on water resources

Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting

This manuscript provides nomenclature recommendations developed by an international workgroup to increase transparency and standardization of pharmacogenetic (PGx) result reporting. Presently, sequence variants identified by PGx tests are described using different nomenclature systems. In addition, PGx analysis may detect different sets of variants for each gene, which can affect interpretation of results. This practice has caused confusion and may thereby impede the adoption of clinical PGx testing. Standardization is critical to move PGx forward

Design, synthesis, and evaluation of rigid probes for the monoamine transporters.

Design, synthesis, and evaluation of rigid probes for the monoamine transporters

The (Plumb) Line: Inheritance and the Hybrid Poem

In One Way Street, Walter Benjamin fabricates a dreamscape in which progenitors are rendered and act on behalf of the unconscious. In this presentation, Appell and Green interrogate the possibility of the hybrid poem accessing lineage intentionally rather than through passive reception, a lineage which neither Benjamin nor the lyric tradition can trace on their own. Green and Appell will read selections representing their respective approaches to hybridity in poetic lineage

Predictive Quantitative Structure–Activity Relationship Modeling of the Antifungal and Antibiotic Properties of Triazolothiadiazine Compounds

Predictive models were developed using two-dimensional quantitative structure activity relationship (QSAR) methods coupled with B3LYP/6-311+G** density functional theory modeling that describe the antimicrobial properties of twenty-four triazolothiadiazine compounds against Aspergillus niger, Aspergillus flavus and Penicillium sp., as well as the bacteria Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa. B3LYP/6-311+G** density functional theory calculations indicated the triazolothiadiazine derivatives possess only modest variation between the frontier orbital properties. Genetic function approximation (GFA) analysis identified the topological and density functional theory derived descriptors for antimicrobial models using a population of 200 models with one to three descriptors that were crossed for 10,000 generations. Two or three descriptor models provided validated predictive models for antifungal and antibiotic properties with R2 values between 0.725 and 0.768 and no outliers. The best models to describe antimicrobial activities include descriptors related to connectivity, electronegativity, polarizability, and van der Waals properties. The reported method provided robust two-dimensional QSAR models with topological and density functional theory descriptors that explain a variety of antifungal and antibiotic activities for structurally related heterocyclic compounds

Determination of pH Effects on Phosphatidyl-Hydroxytyrosol and Phosphatidyl-Tyrosol Bilayer Behavior

A robust method was developed to investigate the liposomal behavior of novel enzymatically-synthesized hydroxytyrosol and tyrosol phospholipids. Bilayer characteristic obtained by this method, including bilayer formation stability and adsorption properties, were explored using dynamic light scattering, zeta-potential measurements, and quartz crystal microbalance with dissipation monitoring (QCMD), respectively. Liposome diameters were found to typically increase from pH 5.5 to pH 10. Zeta potentials values, on the other hand, were found to be well below &#8722;25 mV at all pH conditions explored, with the lowest values (and thus, the best liposome stability) at pH 5.5 or pH 10. Quartz crystal microbalance with dissipation monitoring measurements demonstrated that 100% 1,2-dioloeoylphosphatidyl-hydroxytyrosol (DOPHT) liposomes adsorbed intact onto silica in buffer conditions at pH 5.5 and with no calcium, or at pH 7.5 with calcium (no adsorption was detected at pH 10). 1,2-Dioleoylphosphatidyl-tyrosol (DOPT) liposomes were shown to adsorb intact under buffer conditions only at pH 5.5 with and without calcium. 1,2-Dioleoylphosphatidyl-2-phenolethanol (DOPPE), in comparison, readily adsorbed intact at pH 7.5 without calcium and just slightly at pH 5.5 with calcium present, but formed a supported bilayer over hours at pH 5.5 in the absence of calcium ions

Biophysical characterization of α-glucan nanoparticles encapsulating feruloylated soy glycerides (FSG)

Water insoluble α-glucans that were enzymatically synthesized using glucansucrase that was cloned from Leuconostoc mesenteroides NRRL B-1118 were previously shown to form nanoparticles via high pressure homogenization. These α-glucan nanoparticles were previously shown capable of encapsulating a small hydrophobic molecule. This work demonstrates that the same α-glucan can be formed into nanoparticles that encapsulate feruloylated soy glycerides from modified soybean oil, a product of interest to the cosmetic and skin care industries because of the UV absorbance and antioxidant properties of the feruloyl moiety. It is demonstrated that the feruloylated soy glyceride/α-glucan nanoparticles have distinct size, zeta potential and thermal profiles from that of nanoparticles made from α-glucan alone or feruloylated soy glyceride alone. Thermal analysis also demonstrates the release of feruloylated soy glycerides from the α-glucan nanoparticles