Removal of luminal content protects the small intestine during hemorrhagic shock but is not sufficient to prevent lung injury.

The small intestine plays a key role in the pathogenesis of multiple organ failure following circulatory shock. Current results show that reduced perfusion of the small intestine compromises the mucosal epithelial barrier, and the intestinal contents (including pancreatic digestive enzymes and partially digested food) can enter the intestinal wall and transport through the circulation or mesenteric lymph to other organs such as the lung. The extent to which the luminal contents of the small intestine mediate tissue damage in the intestine and lung is poorly understood in shock. Therefore, rats were assigned to three groups: No-hemorrhagic shock (HS) control and HS with or without a flushed intestine. HS was induced by reducing the mean arterial pressure (30 mmHg; 90 min) followed by return of shed blood and observation (3 h). The small intestine and lung were analyzed for hemorrhage, neutrophil accumulation, and cellular membrane protein degradation. After HS, animals with luminal contents had increased neutrophil accumulation, bleeding, and destruction of E-cadherin in the intestine. Serine protease activity was elevated in mesenteric lymph fluid collected from a separate group of animals subjected to intestinal ischemia/reperfusion. Serine protease activity was elevated in the plasma after HS but was detected in lungs only in animals with nonflushed lumens. Despite removal of the luminal contents, lung injury occurred in both groups as determined by elevated neutrophil accumulation, permeability, and lung protein destruction. In conclusion, luminal contents significantly increase intestinal damage during experimental HS, suggesting transport of luminal contents across the intestinal wall should be minimized

Perceived weight discrimination mediates the prospective relation between obesity and depressive symptoms in US and UK adults

Objective: Obesity has been shown to increase risk of depression. Persons with obesity experience discrimination because of their body weight. Across 3 studies, we tested for the first time whether experiencing (perceived) weight-based discrimination explains why obesity is prospectively associated with increases in depressive symptoms. Method: Data from 3 studies, including the English Longitudinal Study of Ageing (2008/2009–2012/2013), the Health and Retirement Study (2006/2008–2010/2012), and Midlife in the United States (1995/1996–2004/2005), were used to examine associations between obesity, perceived weight discrimination, and depressive symptoms among 20,286 U.S. and U.K. adults. Results: Across all 3 studies, Class II and III obesity were reliably associated with increases in depressive symptoms from baseline to follow-up. Perceived weight-based discrimination predicted increases in depressive symptoms over time and mediated the prospective association between obesity and depressive symptoms in all 3 studies. Persons with Class II and III obesity were more likely to report experiencing weight-based discrimination, and this explained approximately 31% of the obesity-related increase in depressive symptoms on average across the 3 studies. Conclusion: In U.S. and U.K. samples, the prospective association between obesity (defined using body mass index) and increases in depressive symptoms in adulthood may in part be explained by perceived weight discrimination

Transacting Expertise in Emergency Management and Response

In this paper we extend transactive memory systems (TMS) theory to develop an understanding of the distributed coordination of expertise in high-reliability organizations. We illustrate our conceptual developments in a study of emergency management and response in Greece. We focus on the interaction between operators/dispatchers, ambulance crew, and specialist doctors, including the information and communication technologies (ICT) they use to respond to emergency incidents. Our case contributes to an in-depth understanding of the ways in which high-reliability organizations can sustain a distributed coordination of expertise over the duration of emergency incidents. This is achieved through the cultivation of TMS during a socialization and training period, the dynamic development of trust in emergent actions, and a commitment to shared protocols, which allow for improvisation and bricolage during unexpected incidents. Our findings also explore the role of ICTs in inscribing TMS in computerized protocols, while mediating the development of trust across the team, as well as mediating the construction of running narratives, which enable leaders to coordinate expertise in unexpected incidents

Does knowing hurt? Perceiving oneself as overweight predicts future physical health and well-being

Self-identification as being ‘overweight’ may be associated with adverse health outcomes, yet prospective evidence examining this possibility is lacking. Over 7-years, we examined associations between perceived overweight and subsequent health in a sample of 3,582 US adults. Perceived overweight predicted longitudinal declines in subjective health (d =.22, p <.001), increases in depressive symptoms (d =.09, p < .05), and raised levels of physiological dysregulation (d =.24, p <.001) as gauged by clinical indicators of cardiovascular, inflammatory and metabolic functioning. These associations remained after controlling for a range of potential confounders and were observed irrespective of whether self-perceptions of overweight were accurate or inaccurate. The present research highlights the possibility that self-identification as overweight may act independently of body mass index to contribute to unhealthy profiles of physiological functioning and impaired health over time. These findings underscore the importance of evaluating whether weight feedback interventions may have unforeseen adverse consequence

Self-perceived overweight, weight loss attempts, and weight gain: Evidence from two large, longitudinal cohorts

Objective: Self-identification of overweight is associated with a greater desire to lose weight, but also counterintuitively with increased future weight gain. The present research examined whether weight loss attempts mediate the prospective relation between self-perceived weight status and weight gain across adolescence and young adulthood. Method: Data from 2 longitudinal cohort studies was used. Study 1 tested whether the association between self-perceived weight status and weight gain (from age 10/11–14/15 years) was mediated by weight loss attempts among Australian adolescents. Study 2 focused on young adults based in the United States and examined whether attempts at weight loss mediated the relation between self-perceived overweight and weight gain from ages 16 to 28 years. Results: In Study 1, self-perceived weight status among adolescents was associated with greater weight gain and weight loss attempts mediated 16% of this relation. In Study 2, young adults who perceived their weight status as overweight gained more weight over time and weight loss attempts mediated 27% of this relation. Conclusions: Adolescents and young adults that identify they are overweight are more likely to gain weight over time and weight loss attempts appear to mediate this effect

Sosialisasi dan Pelatihan Teknik dan Tata Cara Pengukuran Antropometri Bagi Peneliti di Pusat Riset Teknologi Pengujian dan Standar, Badan Riset dan Inovasi Nasional (BRIN)

The activity aimed to provide knowledge about anthropometry and the measurements illustration for researchers in the Pusat Riset Teknologi Pengujian dan Standar (PRTPS – BRIN). During workshop, the participants were provided with the basic knowledge of anthropometry, standardization of measurement, measurement illustrations and how to apply such data for design, in particular for school furniture design. In addition, the participants were also demonstrated the use of instruments in the laboratory.  In this workshop, 15 researchers participated in both workshop and instrument demonstration

Finite element analysis of in-situ distortion and bulging for an arbitrarily curved additive manufacturing directed energy deposition geometry

With the recent rise in the demand for additive manufacturing (AM), the need for reliable simulation tools to support experimental efforts grows steadily. Computational welding mechanics approaches can simulate the AM processes but are generally not validated for AM-specific effects originating from multiple heating and cooling cycles. To increase confidence in the outcomes and to use numerical simulation reliably, the result quality needs to be validated against experiments for in-situ and post-process cases. In this article, a validation is demonstrated for a structural thermomechanical simulation model on an arbitrarily curved Directed Energy Deposition (DED) part: at first, the validity of the heat input is ensured and subsequently, the model’s predictive quality for in-situ deformation and the bulging behaviour is investigated. For the in-situ deformations, 3D-Digital Image Correlation measurements are conducted that quantify periodic expansion and shrinkage as they occur. The results show a strong dependency of the local stiffness of the surrounding geometry. The numerical simulation model is set up in accordance with the experiment and can reproduce the measured 3-dimensional in-situ displacements. Furthermore, the deformations due to removal from the substrate are quantified via 3D-scanning, exhibiting considerable distortions due to stress relaxation. Finally, the prediction of the deformed shape is discussed in regards to bulging simulation: to improve the accuracy of the calculated final shape, a novel extension of the model relying on the modified stiffness of inactive upper layers is proposed and the experimentally observed bulging could be reproduced in the finite element model

Sutin, A.R., Robinson, E., Daly, M., & Terracciano, A.

Background: Childhood bullying has long-term negative mental and physical health correlates, including weight gain and symptoms of depression. The purpose of this research is to examine whether bullying in the first year of school is associated with greater weight gain by early adolescence and whether adolescent depressive symptoms mediate this association.  Methods: Data were drawn from the Longitudinal Study of Australian Children. Children (N = 3929) were measured every 2 years; BMI and waist circumference were available from ages 4 to 15. Parents reported on bullying at age 6. Children reported on their depressive symptoms at ages 12–13.  Results: Participants who weighed in the obese category at age 4 had an over 50% increased risk of being bullied in school at age 6. Being bullied at age 6 was associated with excess weight gain between ages 6 and 15, defined as either BMI or waist circumference. Depressive symptoms at age 12 partially explained the association between bullying and increases in adiposity. None of the associations varied by gender.  Conclusions: Similar to other forms of peer victimization, bullying early in school is associated with greater weight gain through early adolescence; depressive symptom is one mechanism that contributes to this association

Telling people they are overweight: helpful, harmful or beside the point?

First paragraph: Weight status misperception refers to when a person’s subjective perception of their own or another person’s objective weight status is incorrect. Parents of children with overweight and obesity often fail to identify their child as being ‘overweight’ and in a similar vein, a large number of adults, adolescents and children with overweight or obesity fail to recognise that they are overweight. These observations are not new and have long been presumed to be a concern; if people do not realise they are overweight, how will they change their behavior to lose weight? For example, the failure of parents to identify their children as overweight has recently been described as ‘promoting the silent rise’ of obesity and new research reported in the International Journal of Obesity suggests that healthcare professionals not notifying children and their families of their ‘unhealthy weight status’ is a missed opportunity to combat obesity . These sentiments are echoed in public health intervention approaches. One example is national weight measurement programmes that monitor child weight and notify parents if their child has an ‘unhealthy’ weight status. The presumption that ignorance is damaging in this context has face value and is supported by some cross-sectional evidence, as numerous studies have shown that individuals who fail to recognise they are overweight are less likely to be attempting weight loss. However the best prospective evidence to date suggests that ignorance may be bliss when it comes to overweight and obesity.Output Type: Editoria

Perceived Body Discrimination and Intentional Self-Harm and Suicidal Behavior in Adolescence

Background: This study examines whether discrimination based on the body is associated with intentional self-harm and suicidal behavior in adolescence. Methods: Participants were from the Longitudinal Study of Australian Children (N = 2948; 48% female). Discrimination and items on self-harm and suicidal behavior were measured in the Wave 6 assessment, when study participants were 14–15 years old. BMI, depressive symptoms, peer victimization, and weight self-perception were also assessed. Results: Discrimination was associated with increased risk of thoughts of self-harm (OR = 2.41, 95% CI = 1.88–3.10), hurting the self on purpose (OR = 2.27, 95% CI = 1.67–3.08), considering suicide (OR = 2.17, 95% CI = 1.59–2.96), having a suicide plan (OR = 2.50, 95% CI = 1.81–2.47), attempting suicide (OR = 1.96, 95% CI = 1.30–2.96), controlling for sociodemographic factors, BMI, and depressive symptoms. These associations generally held adjusting for peer victimization or weight self-perception. Conclusions: Weight discrimination has been associated consistently with poor outcomes in adulthood. The present research indicates these associations extend to adolescence and an extremely consequential outcome: the social experience of weight increases risk of intentional self-harm and suicidal behavior