Functionalization of polymers and carbon nanomaterials with low molecular weight receptors

Wydział Chemii: Zakład Chemii SupramolekularnejKontrolowana, chemiczna funkcjonalizacja materiałów poprzez wprowadzanie do ich struktury określonych grup funkcyjnych umożliwia zmianę ich właściwości fizykochemicznych lub nadawanie im specjalnych zastosowań. Celem naukowym mojej pracy jest opracowanie metody syntezy i otrzymanie nowych, funkcjonalnych materiałów węglowych i polimerów zawierających receptory molekularne. Układy te mają wykazywać zdolność selektywnego wiązania jonów i cząsteczek oraz wykazywać zdefiniowane właściwości. W celu otrzymania nowych matryc dla techniki MALDI-MS, które nie generowałyby sygnałów na widmie mas w rejonie niskich mas cząsteczkowych, przeprowadziłem funkcjonalizację nanorurek węglowych poprzez przyłączenie do ich powierzchni kwasu sinapowego. Uzyskane w ten sposób materiały zastosowałem jako matryce w analizie MALDI-MS surfaktantów, kwasu foliowego oraz wankomycyny. Przeprowadzenie funkcjonalizacji określonych polimerów wymagało ode mnie uzyskania receptorów, które jednocześnie będą selektywne wobec odpowiedniego analitu i reaktywne względem grup funkcyjnych obecnych w strukturze polimeru. Pierwszym celem funkcjonalizacji polimerów było uzyskanie materiałów zdolnych do tworzenia selektywnych oddziaływań z cukrami i diolami. Drugim celem funkcjonalizacji polimerów było uzyskanie materiałów zdolnych do adsorpcji kationów metali przejściowych.Controlled chemical functionalization of materials achieved by introduction of defined functional groups to their structure, permits endowing the materials with specific target properties. The aim of my doctoral dissertation was to design a method for the synthesis and to synthesise new functionalized carbon materials and polymers, containing molecular receptors capable of selective binding ions or molecules and showing defined properties. One of my tasks was to obtain new matrices to be employed for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), which would not generate signals in the mass spectra in the region of low molecular mass. I functionalized carbon nanotubes surface with sinapic. The materials obtained were applied as matrices in the MALDI-MS analyses of surfactants, folic acid and vancomycin. In order to functionalize certain polymers, it was necessary to obtain receptors that would be selective towards a given analyte and reactive towards the functional groups present in the polymer structure. The first task was to obtain materials capable of selective interactions with sugars and diols. The second aim of polymer functionalization was to obtain materials capable of adsorption of transition metal cations

The 42nd Symposium Chromatographic Methods of Investigating Organic Compounds : Book of abstracts

The 42nd Symposium Chromatographic Methods of Investigating Organic Compounds : Book of abstracts. June 4-7, 2019, Szczyrk, Polan

EGDMA- and TRIM-Based Microparticles Imprinted with 5-Fluorouracil for Prolonged Drug Delivery

Imprinted materials possess designed cavities capable of forming selective interactions with molecules used in the imprinting process. In this work, we report the synthesis of 5-fluorouracil (5-FU)-imprinted microparticles and their application in prolonged drug delivery. The materials were synthesized using either ethylene glycol dimethacrylate (EGDMA) or trimethylolpropane trimethacrylate (TRIM) cross-linkers. For both types of polymers, methacrylic acid was used as a functional monomer, whereas 2-hydroxyethyl methacrylate was applied to increase the final materials’ hydrophilicity. Adsorption isotherms and adsorption kinetics were investigated to characterize the interactions that occur between the materials and 5-FU. The microparticles synthesized using the TRIM cross-linker showed higher adsorption properties towards 5-FU than those with EGDMA. The release kinetics was highly dependent upon the cross-linker and pH of the release medium. The highest cumulative release was obtained for TRIM-based microparticles at pH 7.4. The IC50 values proved that 5-FU-loaded TRIM-based microparticles possess cytotoxic activity against HeLa cell lines similar to pure 5-FU, whereas their toxicity towards normal HDF cell lines was ca. three times lower than for 5-FU

MS data for FAPA measurements

FAPA-MS data for ambient plasma mass spectrometry</p

FT-IR

FT-IR data for materials obtained in the project 2021/43/D/ST5/01190</p

Data obtained for publication Mat Res Bull 167 (2023) 112438

Data obtained for publication Mat Res Bull 167 (2023) 112438</p

Data obtained for publication Appl Surf Sci 638 (2023) 158089

Data obtained for publication Appl Surf Sci 638 (2023) 158089</p

Functional polymers as unique materials applied in selective adsorption

Functional polymers are increasingly being used as materials with a range of unique properties. Due to their structure and relatively high flexibility in a synthetic context, they are becoming highly relevant in a variety of applications. One of the numerous examples of the use of functional polymers is water treatment. Using the adsorption phenomenon, it is possible to remove or reduce the amount of harmful organic compounds and heavy metal ions in the water. This review provides information on both the synthesis methods and characterization of functional polymers in terms of their adsorption properties. Among others, this paper presents the results of research on functional polymers carried out by Professor Schroeder's research group. The research was mainly focused on the selective adsorption of dyes and heavy metal ions, which are significant water pollutants. The overall results show that the adsorption of the synthesized polymer materials is high influenced by parameters such as pH, temperature, contact time of the adsorbent with the adsorbate and the initial adsorbate concentration. In the case of the adsorption phenomenon, the Langmuir or Freundlich isotherm turned out to be the most appropriate model for the tested materials, while in the case of kinetic models, the highest R2 coefficient was usually obtained using the pseudo-second-order equation

Data obtained for publication Chem Eng J 473 (2023) 145168

Data obtained for publication Chem Eng J 473 (2023) 145168</p