8,013 research outputs found

    Fiber Based Multiple-Access Optical Frequency Dissemination

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    We demonstrate a fiber based multiple-access optical frequency dissemination scheme. Without using any additional laser sources, we reproduce the stable disseminated frequency at an arbitrary point of fiber link. Relative frequency stability of 3E10^{-16}/s and 4E10^{-18}/10^4s is obtained. A branching fiber network for highly-precision synchronization of optical frequency is made possible by this method and its applications are discussed.Comment: 5 pages, 3 figure

    Activation of additional energy dissipation processes in the magnetization dynamics of epitaxial chromium dioxide films

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    The precessional magnetization dynamics of a chromium dioxide(100)(100) film is examined in an all-optical pump-probe setup. The frequency dependence on the external field is used to extract the uniaxial in-plane anisotropy constant. The damping shows a strong dependence on the frequency, but also on the laser pump fluency, which is revealed as an important experiment parameter in this work: above a certain threshold further channels of energy dissipation open and the damping increases discontinuously. This behavior might stem from spin-wave instabilities

    Controlled release of recombinant human cementum protein 1 from electrospun multiphasic scaffold for cementum regeneration

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    Periodontitis is a major cause for tooth loss, which affects about 15% of the adult population. Cementum regeneration has been the crux of constructing the periodontal complex. Cementum protein 1 (CEMP1) is a cementum-specific protein that can induce cementogenic differentiation. In this study, poly(ethylene glycol) (PEG)-tabilized amorphous calcium phosphate (ACP) nanoparticles were prepared by wet-chemical method and then loaded with recombinant human CEMP1 (rhCEMPl) for controlled release. An electrospun multiphasic scaffold constituted of poly(ε-caprolactone) (PCL), type I collagen (COL), and rhCEMPl/ACP was fabricated. The effects of rhCEMPl/ACP/PCL/COL scaffold on the attachment proliferation, osteogenic, and cementogenic differentiations of human periodontal ligament cells, (PDLCs) were systematically investigated. A critical size defect rat model was introduced to evaluate the effect of tissue regeneration of the scaffolds in vivo. The results showed that PEG-stabilized ACP nanoparticles formed a core-shell structure with sustained release of rhCEMP1 for up to 4 weeks. rhCEMPl/ACP/PCL/COL scaffold could suppress PDLCs proliferation behavior and upregulate the expression of cementoblastic markers including CEMP1 and cementum attachment protein while downregulating osteoblastic markers including osteocalcin and osteopontin when it was cocultured with PDLCs in vitro for 7 days. Histology analysis of cementum after being implanted with the scaffold in rats for 8 weeks showed that there was cementum-like tissue formation but little bone formation. These results indicated the potential of using electrospun multiphasic scaffolds for controlled release of rhCEMP1 for promoting cementum regeneration in reconstruction of the periodontal complex

    Hydrogen Sulfide Mitigates Myocardial Infarction via Promotion of Mitochondrial Biogenesis-Dependent M2 Polarization of Macrophages.

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    Published onlineJOURNAL ARTICLEAIMS: Macrophages are of key importance for tissue repair after myocardial infarction (MI). Hydrogen sulfide (H2S) has been shown to exert cardioprotective effects in MI. However, the mechanisms by which H2S modulates cardiac remodeling and repair post-MI remain to be clarified. RESULTS: In our current study, we showed H2S supplementation ameliorated pathological remodeling and dysfunction post-MI in WT and CSE-KO mice, resulting in decreased infarct size and mortality, accompanied by an increase in the number of M2-polarized macrophages at the early stage of MI. Strikingly, adoptive transfer of NaHS-treated (BMMs) into WT and CSE-KO mice with depleted macrophages also ameliorated MI-induced cardiac functional deterioration. Further mechanistic studies demonstrated that NaHS-induced M2 polarization was achieved by enhanced mitochondrial biogenesis and fatty acid oxidation (FAO). INNOVATION AND CONCLUSION: Our study shows, for the first time, that H2S may have the potential as a therapeutic agent for MI via promotion of M2 macrophage polarization.This work was funded by the Key Program of National Nature Science Foundation of China (No.81330080) and the Key Program of Shanghai Committee of Science and Technology in China (No. 14JC1401100)
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