Acute myocardial infarction in a patient with hypofibrinogenemia: a case report

<p>Abstract</p> <p>Introduction</p> <p>Congenital fibrinogen deficiency is a rare coagulation disorder usually responsible for hemorrhagic diathesis. However, it can be associated with thrombosis and there have been limited reports of arterial thrombotic complications in these patients.</p> <p>Case presentation</p> <p>A 42-year-old Tunisian man with congenital hypofibrinogenemia and no cardiovascular risk factors presented with new onset prolonged angina pectoris. An electrocardiogram showed features of inferior acute myocardial infarction. His troponin levels had reached 17 ng/L. Laboratory findings confirmed hypofibrinogenemia and ruled out thrombophilia. Echocardiography was not useful in providing diagnostic elements but did show preserved left ventricular function. Coronary angiography was not performed and our patient did not receive any anticoagulant treatment due to the major risk of bleeding. Magnetic resonance imaging confirmed myocardial necrosis. Our patient was managed with aspirin, a beta-blocker, an angiotensin-converting enzyme inhibitor and statin medication. The treatment was well tolerated and no ischemic recurrence was detected.</p> <p>Conclusion</p> <p>Although coronary thrombosis is a rare event in patients with fibrinogen deficiency, this condition is of major interest in view of the difficulties observed in managing these patients.</p

Comparison of ZnO thin films on different substrates obtained by sol-gel process and deposited by spin-coating technique

521-529In the present paper, zinc oxide thin films obtained by sol gel process and deposited on glass, sapphire, Si (100), Si (111) and ZnO substrates by spin-coating technique have been studied. Effects of using different substrates on the structural, morphological and optical properties have been investigated. The structural properties have been analyzed using X-ray diffraction (XRD) and the recorded patterns indicated that all the deposited films are polycrystalline with a hexagonal Wurtzite structure and exhibit preferentially oriented along the c-axis direction. The surface morphology has been examined by Scanning Electron Microscopy which revealed that the microstructure of the films strongly affected by the nature and orientation of substrate namely grain shape and size. Optical absorbance measurements have been taken using UV-Vis spectrophotometer and the calculated values of the direct band gap energy are around 3, 3.08 and 3.19 eV, for the ZnO films deposited on ZnO, sapphire c and glass substrates, respectively. Photoluminescence measurements taken at 4 K exhibit a near band edge composed by two principal’s peaks situated at 3.36 and 3.31 eV and attributed to the neutral donor bound exciton (D°X) and to the deep acceptor (A°X), their intensity varied with the nature of substrate

Elaboration and Characterization of Porous Silicon multilayer for biomaterial applications

International audienceIn this work, a combination of optical and electrochemical studies are performed in order to elaborate a suitable porous silicon (PSi) substrate for biosensing and biomaterial applications. We report on the electrochemical behavior of PSi multilayer stabilized by thermal oxidation, applying electrochemical impedance spectroscopy and cyclic voltammetry measurements. The strength of the method is evidenced when adsorption of small (12-mer) peptides is monitored. Our aim is to combine the advantages offered by the large sensing area of the PSi multilayers and the high sensitivity of the electrochemical technique for improved biosensing

Correction to: Surgery and outcome of infective endocarditis in octogenarians: prospective data from the ESC EORP EURO-ENDO registry (Infection, (2022), 50, 5, (1191-1202), 10.1007/s15010-022-01792-0)

In this article the “EURO-ENDO Investigators group” member U. Y. Sinan was incorrectly written as U.S. Yasar. The original article has been corrected