Prototype measuring of erosion and currents under the keel of a sailing ship in a canal

A full scale experiment with a deep loaded push-tow barge combination was carried out in the Juliana Canal to determine the stability of a canal bed against future ship-induced loads. The resulting under keel currents and the subsequent bed erosion were monitored and analyzed. Clearly, the results showed that in the future the canal bed will be instable. The observed bed lowering could be estimated with a time/dependent scour prediction formula. The results of the observed flow velocities under the ship´s keel were comparable with measured flow velocities in small-scale experiments

HLA Immunogenotype Determines Persistent Human Papillomavirus Virus Infection in HIV-Infected Patients Receiving Antiretroviral Treatment

A proportion of human immunodeficiency virus (HIV)–infected patients develop persistent, stigmatizing human papillomavirus (HPV)–related cutaneous and genital warts and anogenital (pre)cancer. This is the first study to investigate immunogenetic variations that might account for HPV susceptibility and the largest to date to categorize the HPV types associated with cutaneous warts in HIV-positive patients. The HLA class I and II allele distribution was analyzed in 49 antiretroviral (ART)–treated HIV-positive patients with persistent warts, 42 noninfected controls, and 46 HIV-positive controls. The allele HLA-B*44 was more frequently identified in HIV-positive patients with warts (P = .004); a susceptible haplotype (HLA-B*44, HLA-C*05; P = .001) and protective genes (HLA-DQB1*06; P = .03) may also contribute. Cutaneous wart biopsy specimens from HIV-positive patients harbored common wart types HPV27/57, the unusual wart type HPV7, and an excess of Betapapillomavirus types (P = .002), compared with wart specimens from noninfected controls. These findings suggest that HLA testing might assist in stratifying those patients in whom vaccination should be recommended

The mammillary bodies: a review of causes of injury in infants and children

SUMMARY: Despite their small size, the mammillary bodies play an important role in supporting recollective memory. However, they have typically been overlooked when assessing neurologic conditions that present with memory impairment. While there is increasing evidence of mammillary body involvement in a wide range of neurologic disorders in adults, very little attention has been given to infants and children. Literature searches of PubMed and EMBASE were performed to identify articles that describe mammillary body pathology on brain MR imaging in children. Mammillary body pathology is present in the pediatric population in several conditions, indicated by signal change and/or atrophy on MR imaging. The main causes of mammillary body pathology are thiamine deficiency, hypoxia-ischemia, direct damage due to masses or hydrocephalus, or deafferentation resulting from pathology within the wider Papez circuit. Optimizing scanning protocols and assessing mammillary body status as a standard procedure are critical, given their role in memory processes

Mammillary body injury in neonatal encephalopathy: a multicentre, retrospective study

Background The mammillary bodies (MBs) have repeatedly been shown to be critical for memory, yet little is known about their involvement in numerous neurological conditions linked to memory impairments, including neonatal encephalopathy. Methods We implemented a multicentre retrospective study, assessing magnetic resonance scans of 219 infants with neonatal encephalopathy who had undergone hypothermia treatment in neonatal intensive care units located in the Netherlands and Italy. Results Abnormal MB signal was observed in similar to 40% of infants scanned; in half of these cases, the brain appeared otherwise normal. MB involvement was not related to the severity of encephalopathy or the pattern/severity of hypoxic-ischaemic brain injury. Follow-up scans were available for 18 cases with abnormal MB signal; in eight of these cases, the MBs appeared severely atrophic. Conclusions This study highlights the importance of assessing the status of the MBs in neonatal encephalopathy; this may require changes to scanning protocols to ensure that the slices are sufficiently thin to capture the MBs. Furthermore, long-term follow-up of infants with abnormal MB signal is needed to determine the effects on cognition, which may enable the use of early intervention strategies. Further research is needed to assess the role of therapeutic hypothermia in MB involvement in neonatal encephalopathy. ImpactThe MBs are particularly sensitive to hypoxia in neonates. Current hypothermia treatment provides incomplete protection against MB injury. MB involvement is likely overlooked as it can often occur when the rest of the brain appears normal. Given the importance of the MBs for memory, it is necessary that this region is properly assessed in neonatal encephalopathy. This may require improvements in scanning protocols.Developmen

Normative mammillary body volumes: From the neonatal period to young adult

The mammillary bodies may be small, but they have an important role in encoding complex memories. Mammillary body pathology often occurs following thiamine deficiency but there is increasing evidence that the mammillary bodies are also compromised in other neurological conditions and in younger ages groups. For example, the mammillary bodies are frequently affected in neonates with hypoxic-ischemic encephalopathy. At present, there is no normative data for the mammillary bodies in younger groups making it difficult to identify abnormalities in neurological disorders. To address this, the present study set out to develop a normative dataset for neonates and for children to young adult. A further aim was to determine whether there were laterality or sex differences in mammillary body volumes. Mammillary body volumes were obtained from MRI scans from 506 participants across two datasets. Measures for neonates were acquired from the Developing Human Connectome Project database (156 male; 100 female); volumes for individuals aged 6–24 were acquired from the NICHE database (166 males; 84 females). Volume measurements were acquired using a semi-automated multi-atlas segmentation approach. Mammillary body volumes increased up to approximately 15 years-of-age. The left mammillary body was marginally, but significantly, larger than the right in the neonates with a similar pattern in older children/young adults. In neonates, the mammillary bodies in males were slightly bigger than females but no sex differences were present in older children/young adults. Given the increasing presentation of mammillary body pathology in neonates and children, these normative data will enable better assessment of the mammillary bodies in healthy and at-risk populations

Stellar Rotation in M35: Mass-Period Relations, Spin-Down Rates, and Gyrochronology

We present the results of a 5 month photometric time-series survey for stellar rotation over a 40'x40' field on the 150 Myr open cluster M35. We report rotation periods for 441 stars and determine their cluster membership and binarity based on a decade-long radial-velocity survey, proper-motion measurements, and multi-band photometric observations. We find that 310 of the stars with measured rotation periods are late-type members of M35. Their distribution of rotation periods span more than two orders of magnitude from ~0.1-15 days, not constrained by the sampling frequency and the time-span of the survey. With an age between the zero-age main-sequence and the Hyades, and with ~6 times more rotation periods than measured in the Pleiades, M35 permit detailed studies of early rotational evolution of late-type stars. Nearly 80% of the 310 rotators lie on two distinct sequences in the color-period plane, defining clear relations between stellar rotation period and color (mass). The M35 color-period diagram enables us to determine timescales for the transition between the two rotational states for G and K dwarfs, respectively. These timescales are inversely related to the mass of the convective envelope, and offer constraints on the rates of internal and external angular momentum transport and of the evolution of stellar dynamos. A comparison to the Hyades, confirm the Skumanich (1972) spindown-dependence for G dwarfs on one rotational state, but suggest that K dwarfs spin down more slowly. The locations of the rotational sequences in the M35 color-period diagram support the use of rotational isochrones to determine ages for coeval stellar populations. We use such gyrochronology to determine "gyro-ages" for M35. We use the M35 data to evaluate new color dependencies for the rotational isochrones.Comment: 73 pages, 16 figures, Accepted for publication in ApJ. Replacement reflect minor changes suggested by refere

An MCMC approach to extracting the global 21-cm signal during the cosmic dawn from sky-averaged radio observations

Efforts are being made to observe the 21-cm signal from the 'cosmic dawn' using sky-averaged observations with individual radio dipoles. In this paper, we develop a model of the observations accounting for the 21-cm signal, foregrounds, and several major instrumental effects. Given this model, we apply Markov Chain Monte Carlo techniques to demonstrate the ability of these instruments to separate the 21-cm signal from foregrounds and quantify their ability to constrain properties of the first galaxies. For concreteness, we investigate observations between 40 and 120 MHz with the proposed DARE mission in lunar orbit, showing its potential for science return.Comment: 16 pages, 14 figures; accepted by MNRAS; minor edits to match accepted versio