216 research outputs found
Een approximatieve functionaalbetrekking van de zetafunctie van Riemann
Bekanntlich besitzen viele Funktionen eine Funktionaigieichung. Ich beschrà nke mich hier auf einige Beispiele. Eine sehr bekannte Relation liefert die Eulersche Gammafunktion, die für K(s) >0 durch das Integral ... Zie: Einleitun
Clinical and Preclinical Treatment Aspects of Castration Resistant Prostate Cancer (CRPC)
In the Western countries prostate cancer is the most frequently diagnosed cancer, except
for skin cancer, and the second leading cause of male cancer deaths. Prostate
cancer tends to develop in men over the age of fifty and although it is one of the most
prevalent types of cancer in men, many patients may never have symptoms, undergo
no therapy, and eventually die from other causes. This is because cancer of the prostate
is, in many cases, slow-growing, symptom-free, and since men with the condition are
older they often die from causes unrelated to the prostate cancer. Men diagnosed with
clinically localized prostate cancer have several treatment options available, including
watchful waiting, definitive radiation therapy and surgery. However, a significant proportion
of patients who present with cancer that appears to be localized will eventually
develop incurable metastatic disease and ultimately succumb to death as a result of
advanced disease. In patients with advanced disease androgen-deprivation therapies
typically result in rapid responses, but eventually nearly all patients develop progressive
castration-resistant disease. Historically, clinical management for metastatic castration
resistant prostate cancer (CRPC) has been primarily focused on relieving symptoms. In
the last decade the therapeutic spectrum has changed dramatically, and our understanding
of the biology of patients with prostate cancer has become far more sophisticated.
The treatment paradigm first changed with the publication of 2 pivotal randomized
clinical trials in 2004, which demonstrated for the first time a survival benefit with
docetaxel-based therapy in patients with metastatic CRPC. Since then, docetaxel chemotherapy
has become the standard first-line treatment in patients with CRPC (Chapter
2). Recently, the landscape for CRPC treatment has changed again with the FDA approval
of three additional therapies, sipuleucel-T5, cabazitaxel6 and abiraterone acetate7.
While the addition of these new treatment options is a great advance for patients with
metastatic CRPC, there are many new questions arising regarding the optimal sequencing
of these treatments as well as potential combinations of and old drugs
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