The role of gender in proposed DSM-5 alcohol use disorder criteria

The high prevalence of alcohol related fatalities and the large population of individuals at risk or diagnosed with alcohol use disorders make understanding the disorders a public health priority. As the publication of the Diagnostic and Statistical Manual of Mental Disorders-fifth edition (DSM-5; n.d.) approaches, a substantial amount of research has focused on how to best conceptualize disorders. Currently, the DSM-IV-TR conceptualizes alcohol use disorders as two categorical diagnoses: abuse and dependence. However, recent research suggests that the diagnostic criteria may be better represented as a continuum. An issue that could inform the debate is whether problematic alcohol use presents itself differently in males and females. Previous research has utilized populations representative of both genders, but little to no research has explicitly focused on the role that gender plays in the nosology of alcohol use disorder. The present study examined the role of gender in the proposed DSM-5 alcohol use disorder diagnostic scheme using a corrections population. Results indicated that there was agreement between dependence categories in the DSM-IV-TR and severe alcohol use categories in the proposed DSM-5 for both genders. The results also indicated that gender differences exist in severity of diagnosis, which could impact treatment decisions. Overall, the proposed DSM-5 may have more clinical justification for diagnosis. The inclusion of an additional criterion was also explored. Results indicated that a “use to relieve emotional distress” criterion may be warranted

The Effects of Stimulant Medication on Free Recall of Story Events among Children with ADHD

This study investigated group differences in the recalls of stories by children with attention-deficit/hyperactivity disorder (ADHD) and comparison peers. Further, the study examined whether stimulant medication improved the story recall of children with ADHD relative to a placebo condition. Children were asked to recall both televised and audio taped stories. Free recall protocols were assessed for what information was recalled as a function of story structure features (i.e. status on or off the causal chain and event importance) and were rated for overall coherence. Relative to comparison peers, children with ADHD showed less influence of story structure features on recall, and produced less coherent recall of the audio taped stories. Medication had only limited effects on the story recall of children with ADHD. Specifically, medication did not increase these children’s sensitivity to events central to the stories and had no effect on the coherence of children’s recalls. The implications of the results for guiding future academic interventions are discussed

How2Sign: A Large-scale Multimodal Dataset for Continuous American Sign Language

One of the factors that have hindered progress in the areas of sign language recognition, translation, and production is the absence of large annotated datasets. Towards this end, we introduce How2Sign, a multimodal and multiview continuous American Sign Language (ASL) dataset, consisting of a parallel corpus of more than 80 hours of sign language videos and a set of corresponding modalities including speech, English transcripts, and depth. A three-hour subset was further recorded in the Panoptic studio enabling detailed 3D pose estimation. To evaluate the potential of How2Sign for real-world impact, we conduct a study with ASL signers and show that synthesized videos using our dataset can indeed be understood. The study further gives insights on challenges that computer vision should address in order to make progress in this field. Dataset website: http://how2sign.github.io/Comment: Accepted at CVPR 2021. Dataset website: http://how2sign.github.io

How2Sign: A large-scale multimodal dataset for continuous American sign language

One of the factors that have hindered progress in the areas of sign language recognition, translation, and production is the absence of large annotated datasets. Towards this end, we introduce How2Sign, a multimodal and multiview continuous American Sign Language (ASL) dataset, consisting of a parallel corpus of more than 80 hours of sign language videos and a set of corresponding modalities including speech, English transcripts, and depth. A three-hour subset was further recorded in the Panoptic studio enabling detailed 3D pose estimation. To evaluate the potential of How2Sign for real-world impact, we conduct a study with ASL signers and show that synthesized videos using our dataset can indeed be understood. The study further gives insights on challenges that computer vision should address in order to make progress in this field. Dataset website: http://how2sign.github.io/This work received funding from Facebook through gifts to CMU and UPC; through projects TEC2016-75976-R, TIN2015- 65316-P, SEV-2015-0493 and PID2019-107255GB-C22 of the Spanish Government and 2017-SGR-1414 of Generalitat de Catalunya. This work used XSEDE’s “Bridges” system at the Pittsburgh Supercomputing Center (NSF award ACI- 1445606). Amanda Duarte has received support from la Caixa Foundation (ID 100010434) under the fellowship code LCF/BQ/IN18/11660029. Shruti Palaskar was supported by the Facebook Fellowship program.Peer ReviewedObjectius de Desenvolupament Sostenible::10 - Reducció de les DesigualtatsObjectius de Desenvolupament Sostenible::4 - Educació de Qualitat::4.5 - Per a 2030, eliminar les disparitats de gènere en l’educació i garantir l’accés en condicions d’igualtat a les persones vulnerables, incloses les persones amb discapacitat, els pobles indígenes i els nens i nenes en situacions de vulnerabilitat, a tots els nivells de l’ensenyament i la formació professionalObjectius de Desenvolupament Sostenible::10 - Reducció de les Desigualtats::10.2 - Per a 2030, potenciar i promoure la inclusió social, econòmica i política de totes les persones, independentment de l’edat, sexe, discapacitat, raça, ètnia, origen, religió, situació econòmica o altra condicióObjectius de Desenvolupament Sostenible::4 - Educació de QualitatPostprint (author's final draft

How2Sign: A large-scale multimodal dataset for continuous American sign language

Trabajo presentado en la IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), celebrada de forma virtual del 19 al 25 de junio de 2021One of the factors that have hindered progress in the areas of sign language recognition, translation, and production is the absence of large annotated datasets. Towards this end, we introduce How2Sign, a multimodal and multiview continuous American Sign Language (ASL) dataset, consisting of a parallel corpus of more than 80 hours of sign language videos and a set of corresponding modalities including speech, English transcripts, and depth. A three-hour subset was further recorded in the Panoptic studio enabling detailed 3D pose estimation. To evaluate the potential of How2Sign for real-world impact, we conduct a study with ASL signers and show that synthesized videos using our dataset can indeed be understood. The study further gives insights on challenges that computer vision should address in order to make progress in this field. Dataset website: http://how2sign.github.io/This work received funding from Facebook through gifts to CMU and UPC; through projects TEC2016-75976-R, TIN2015- 65316-P, SEV-2015-0493 and PID2019-107255GB-C22 of the Spanish Government and 2017-SGR-1414 of Generalitat de Catalunya. This work used XSEDE’s “Bridges” system at the Pittsburgh Supercomputing Center (NSF award ACI1445606). Amanda Duarte has received support from la Caixa Foundation (ID 100010434) under the fellowship code LCF/BQ/IN18/11660029. Shruti Palaskar was supported by the Facebook Fellowship program

Hemodynamic Parameters And Neurogenic Pulmonary Edema Following Spinal Cord Injury: An Experimental Model.

Neurogenic pulmonary edema is a serious and always life-threatening complication following several lesions of the central nervous system. We report an experiment with 58 Wistar-Hanover adult male rats. Two groups were formed: control (n=4) and experimental (n=54). The experimental group sustained acute midthoracic spinal cord injury by Fogarty's balloon-compression technique containing 20 microL of saline for 5, 15, 30 or 60 seconds. The rats were anesthetized by intraperitoneal (i.p.) sodium pentobarbital (s.p.) 60 mg/Kg. The quantitative neurological outcome was presented at 4, 24 and 48 hours from compression to characterize the injury graduation in different groups. Poor outcome occurred with 60 seconds of compression. Six animals died suddenly with pulmonary edema. Using the procedure to investigate the pulmonary edema during 60 seconds of compression, followed by decompression and time-course of 60 seconds, 20 rats were randomly assigned to one of the following groups: control (1, n=4, anesthetized by i.p. s.p., 60 mg/Kg but without compression) and experimental (2, n=7, anesthetized by i.p. xylazine 10 mg/Kg and ketamine 75 mg/Kg) and (3, n=9, anesthetized by i.p. s.p., 60 mg/Kg). The pulmonary index (100 x wet lung weight/body weight) was 0.395 +/- 0.018 in control group, rose to 0.499 +/- 0.060 in group 2, and was 0.639 +/- 0.14 in group 3. Histologic examination of the spinal cord showed parenchymal ruptures and acute hemorrhage. Comparison of the pulmonary index with morphometric evaluation of edema fluid-filled alveoli by light microscopy showed that relevant intra-alveolar edema occurred only for index values above 0.55. The results suggest that the pulmonary edema induced by spinal compression is of neurogenic nature and that the type of anesthesia used might be important for the genesis of lung edema.63990-

Hemodynamic parameters and neurogenic pulmonary edema following spinal cord injury: an experimental model Parâmetros hemodinâmicos e edema pulmonar neurogênico após traumatismo raquimedular: modelo experimental

Neurogenic pulmonary edema is a serious and always life-threatening complication following several lesions of the central nervous system. We report an experiment with 58 Wistar-Hanover adult male rats. Two groups were formed: control (n=4) and experimental (n=54). The experimental group sustained acute midthoracic spinal cord injury by Fogarty’s balloon-compression technique containing 20µL of saline for 5, 15, 30 or 60 seconds. The rats were anesthetized by intraperitoneal (i.p.) sodium pentobarbital (s.p.) 60 mg/Kg. The quantitative neurological outcome was presented at 4, 24 and 48 hours from compression to characterize the injury graduation in different groups. Poor outcome occurred with 60 seconds of compression. Six animals died suddenly with pulmonary edema. Using the procedure to investigate the pulmonary edema during 60 seconds of compression, followed by decompression and time-course of 60 seconds, 20 rats were randomly asigned to one of the following groups: control (1, n=4, anesthetized by i.p. s.p., 60 mg/Kg but without compression) and experimental (2, n=7, anesthetized by i.p. xylazine 10 mg/Kg and ketamine 75 mg/Kg) and (3, n=9, anesthetized by i.p. s.p., 60 mg/Kg). The pulmonary index (100 x wet lung weight / body weight) was 0.395 ± 0.018 in control group, rose to 0.499 ± 0.060 in group 2, and was 0.639 ± 0.14 in group 3. Histologic examination of the spinal cord showed parenchymal ruptures and acute hemorrhage. Comparison of the pulmonary index with morphometric evaluation of edema fluid-filled alveoli by light microscopy showed that relevant intra-alveolar edema occurred only for index values above 0.55. The results suggest that the pulmonary edema induced by spinal compression is of neurogenic nature and that the type of anesthesia used might be important for the genesis of lung edema.<br>Edema pulmonar neurogênico é complicação séria e aumenta o risco de vida em pacientes com várias lesões do sistema nervoso central. Apresentamos uma experiência com 58 ratos Wistar machos e adultos. Foram formados dois grupos: controle (n=4) e experimental (n=54). O grupo experimental sofreu trauma raquimedular torácico médio com o cateter-balão de Fogarty contendo 20µL de salina por 5, 15, 30 ou 60 segundos de compressão. Os ratos foram anestesiados com pentobarbital sódico (p.s.), 60 mg/Kg intraperitoneal (i.p.). Foi investigada a relação entre a lesão medular e o tempo de compressão. A evolução neurológica foi quantificada e apresentada com 4, 24 e 48 horas da compressão para caracterizar a graduação da lesão nos diferentes grupos. A pior evolução ocorreu com 60 segundos de compressão. Seis animais morreram subitamente com edema pulmonar. Vinte ratos foram randomicamente distribuídos em um dos seguintes grupos: controle (1, n=4, anestesiados com p.s. i.p., 60 mg/Kg, mas sem compressão) e experimental (2, n=7, anestesiados com xilasina 10 mg/Kg e ketamina 75 mg/Kg) e (3, n=9, anestesiados com p.s. i.p., 60 mg/Kg). O índice pulmonar (100 x peso pulmonar / peso corporal) foi 0,395 ± 0,018 no grupo controle, 0,499 ± 0,060 no grupo 2, e 0,639 ± 0,14 no grupo 3. O exame histológico da medula espinhal mostrou rupturas no parênquima e hemorragia aguda. Comparando-se o índice pulmonar com o índice morfométrico através da microscopia óptica, evidenciou-se que ocorreu edema intra-alveolar relevante para índices acima de 0,55. A presente experiência sugere que o edema pulmonar induzido pela compressão medular é de natureza neurogênica e que o tipo de anestesia utilizada no experimento poderia ter participação na gênesis do edema pulmonar