Transverse Observables and Mass Determination at Hadron Colliders

I consider the two-body decay of a particle at a hadron collider into a visible and an invisible particle, generalizing $W \to e \nu$, where the masses of the decaying particle and the invisible decay particle are, {\em a priori}, unknown. I prove that the transverse mass, when maximized over possible kinematic configurations, can be used to determine both of the unknown masses. I argue that the proof can be generalized to cover cases such as decays of pair-produced superpartners to the lightest, stable superpartner at the Large Hadron Collider.Comment: 4 pages; version published in JHE

Methodology for Process Improvement Through Basic Components and Focusing on the Resistance to Change.

This paper describes a multi-model methodology that implements a smooth and continuous process improvement, depending on the organization's business goals and allowing users to establish their improvement implementation pace. The methodology focuses on basic process components known as ‘best practices’. Besides, it covers following the topics: knowledge management and change management. The methodology description and the results of a case study on project management process are included

Satisfactory safety and immunogenicity of MSP3 malaria vaccine candidate in Tanzanian children aged 12-24 months.

BACKGROUND: Development and deployment of an effective malaria vaccine would complement existing malaria control measures. A blood stage malaria vaccine candidate, Merozoite Surface Protein-3 (MSP3), produced as a long synthetic peptide, has been shown to be safe in non-immune and semi-immune adults. A phase Ib dose-escalating study was conducted to assess the vaccine's safety and immunogenicity in children aged 12 to 24 months in Korogwe, Tanzania (ClinicalTrials.gov number: NCT00469651). METHODS: This was a double-blind, randomized, controlled, dose escalation phase Ib trial, in which children were given one of two different doses of the MSP3 antigen (15 microg or 30 microg) or a control vaccine (Engerix B). Children were randomly allocated either to the MSP3 candidate malaria vaccine or the control vaccine administered at a schedule of 0, 1, and 2 months. Immunization with lower and higher doses was staggered for safety reasons starting with the lower dose. The primary endpoint was safety and reactogenicity within 28 days post-vaccination. Blood samples were obtained at different time points to measure immunological responses. Results are presented up to 84 days post-vaccination. RESULTS: A total of 45 children were enrolled, 15 in each of the two MSP3 dose groups and 15 in the Engerix B group. There were no important differences in reactogenicity between the two MSP3 groups and Engerix B. Grade 3 adverse events were infrequent; only five were detected throughout the study, all of which were transient and resolved without sequelae. No serious adverse event reported was considered to be related to MSP3 vaccine. Both MSP3 dose regimens elicited strong cytophilic IgG responses (subclasses IgG1 and IgG3), the isotypes involved in the monocyte-dependant mechanism of Plasmodium falciparum parasite-killing. The titers reached are similar to those from African adults having reached a state of premunition. Furthermore, vaccination induced seroconversion in all vaccinees. CONCLUSION: The MSP3 malaria vaccine candidate was safe, well tolerated and immunogenic in children aged 12-24 months living in a malaria endemic community. Given the vaccine's safety and its induction of cytophilic IgG responses, its efficacy against P. falciparum infection and disease needs to be evaluated in Phase 2 studies

A lens-coupled scintillation counter in cryogenic environment

In this work we present an elegant solution for a scintillation counter to be integrated into a cryogenic system. Its distinguishing feature is the absence of a continuous light guide coupling the scintillation and the photodetector parts, operating at cryogenic and room temperatures respectively. The prototype detector consists of a plastic scintillator with glued-in wavelength-shifting fiber located inside a cryostat, a Geiger-mode Avalanche Photodiode (G-APD) outside the cryostat, and a lens system guiding the scintillation light re-emitted by the fiber to the G-APD through optical windows in the cryostat shields. With a 0.8mm diameter multiclad fiber and a 1mm active area G-APD the coupling efficiency of the "lens light guide" is about 50%. A reliable performance of the detector down to 3K is demonstrated.Comment: 14 pages, 11 figure

Fracture driven by a Thermal Gradient

Motivated by recent experiments by Yuse and Sano (Nature, 362, 329 (1993)), we propose a discrete model of linear springs for studying fracture in thin and elastically isotropic brittle films. The method enables us to draw a map of the stresses in the material. Cracks generated by the model, imposing a moving thermal gradient in the material, can branch or wiggle depending on the driving parameters. The results may be used to compare with other recent theoretical work, or to design future experiments.Comment: RevTeX file (9 pages) and 5 postscript figure

Thouless energy of a superconductor from non local conductance fluctuations

We show that a spin-up electron from a normal metal entering a superconductor propagates as a composite object consisting of a spin-down hole and a pair in the condensate. This leads to a factorization of the non local conductance as two local Andreev reflections at both interfaces and one propagation in the superconductor, which is tested numerically within a one dimensional toy model of reflectionless tunneling. Small area junctions are characterized by non local conductance fluctuations. A treatment ignoring weak localization leads to a Thouless energy inverse proportional to the sample size, as observed in the numerical simulations. We show that weak localization can have a strong effect, and leads to a coupling between evanescent quasiparticles and the condensate by Andreev reflections ``internal'' to the superconductor.Comment: 11 pages, 12 figures, revised manuscrip

Public perceptions of 'negging': lowering women’s self-esteem to increase the male attractiveness and achieve sexual conquest

Purpose: ‘Negging’ can be described as the purposeful lowering of a woman’s self-esteem to increase perceived attractiveness of the man in order to achieve sexual conquest. Negging has evolved over time. Whilst ‘Original’ negging was intended to be a harmless tool for attracting women, more recently dating companies have been teaching men ‘Evolved’ negging in a potentially damaging way, which could escalate into an abusive intimate relationship. Design: An online survey involving vignettes depicting negging between strangers with three conditions; ‘Original’, ‘Evolved’ and ‘Control’ was completed by 308 participants. Participants were asked how harmful, acceptable, and how likely to escalate each scenario was. A fourth vignette described ‘Evolved’ negging between partners. Results: Mixed methods ANOVA indicated that participants perceived all negging as being significantly more harmful than control ‘pick-up’ lines. ‘Evolved’ negging was considered to be more likely to escalate in seriousness than ‘Original’ negging. Conclusions: Despite the public viewing negging as harmful and with the potential to escalate in seriousness, women are still being targeted in this manner and the industry ‘teaching’ negging is growing despite controversy. This study aims to increase general awareness of negging in order to minimise harm caused to women who are ‘picked-up’ through this technique. To this end, directions for future research are highlighted. Originality: This paper is one of the first empirical studies in the area of negging. The perceived, and potential, harm caused can be studied in light of these novel findings with the aim of protecting women from harm