Photometry of SN 2002bo with template image subtraction

VRI photometry of the type Ia supernova 2002bo is presented. This SN exploded in a dusty region of the host galaxy NGC 3190, thus, subtraction of a template frame was necessary to obtain reliable photometry. We used a template frame of NGC 3190 taken during the course of our galaxy imaging project, fortunately, just a few days before SN 2002bo was discovered. The aim of this project is to collect template frames of nearby galaxies that are potential hosts of bright SNe. Subtraction of pre-SN images helped us to exclude the background light contamination of the host galaxy. The maximum occurred at JD 2452346, with maximal V brightness of 13.58. MLCS analysis led to T0(B)=JD 2452346.1 pm 0.8 (fiducial B-maximum), E(B-V)=0.24 pm 0.02, mu0=32.46 pm 0.06, Delta=-0.14 pm 0.04. E(B-V)=0.24(2) indicates a significant extinction in the host galaxy as the galactic reddening is negligible toward NGC 3190. The accepted value of Delta indicates that SN 2002bo was a slightly overluminous SN by about 0.14 relative to fiducial SN Type Ia. The distance turned out to be 31.0 pm 3 Mpc. In addition, the heavily obscured SN 2002cv was also detected on the I frame taken on JD 2452434 (June 8, 2002), and a variable star is found in the field, very close to the host galaxy.Comment: accepted by Astronomy and Astrophysic

The weakening outburst of the young eruptive star V582 Aur

V582 Aur is a pre-main-sequence FU Orionis type eruptive star, which entered a brightness minimum in 2016 March due to changes in the line-of-sight extinction. Here, we present and analyze new optical B, V, R C , and I C band multiepoch observations and new near-infrared J, H, and K S band photometric measurements from 2018 January–2019 February, as well as publicly available midinfrared Wide-field Infrared Survey Explorer (WISE) data. We found that the source shows a significant optical–near-infrared variability, and the current brightness minimum has not completely finished yet. If the present dimming originates from the same orbiting dust clump that caused a similar brightness variation in 2012, then our results suggest a viscous spreading of the dust particles along the orbit. Another scenario is that the current minimum is caused by a dust structure, that is entering and leaving the inner part of the system. The WISE measurements could be consistent with this scenario. Our long-term data, as well as an accretion disk modeling hint at a general fading of V582 Aur, suggesting that the source will reach the quiescent level in ~80 yr

Outcome predictors of smoking cessation treatment provided by an addiction care unit between 2007 and 2010

Objective: To analyze the predictors of smoking cessation treatment outcomes in a sample with a high rate of medical and psychiatric disorders and addictions. Methods: Analysis of predictors of success of a 6-week treatment provided by an addiction care unit (CAPS-AD) to 367 smokers in Brazil from 2007 to 2010. Forty variables were collected at baseline. Success was defined as abstinence from smoking for a period of at least 14 consecutive days, including the last day of treatment. Twenty variables were selected for the logistic regression model. Results: The only condition correlated with successful treatment after logistic regression was smoking one's first cigarette 5 minutes or more after waking (beta = 1.85, 95% confidence interval [95%CI] = 1.11-3.10, p = 0.018). Subjects with hypertension and alcohol use disorders and those who were undergoing psychiatric treatment showed success rates comparable to or greater than the average success rate of the sample (34.2-44.4%). Conclusions: These findings support the importance of the variable time to first cigarette in treatment outcomes for a sample with a high rate of clinical and psychiatric disorders. Good success rates were observed for pharmacological treatment, which was combined with group therapy based on cognitive-behavioral concepts and integrated into ongoing treatment of other addictions and psychiatric disorders

Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Intravenously injected nanopharmaceuticals induce adverse cardiopulmonary reactions in sensitive human subjects and these reactions are reproducible in pigs. The underlying mechanisms are poorly understood, but a role for both the complement system and reactive macrophages has been implicated. Here we show the dominance and importance of early pulmonary intravascular macrophage clearance kinetics in adverse particle-mediated cardiopulmonary distress in pigs and irrespective of complement activation. Delaying particle recognition by macrophages within the first few minutes of injection overcome adverse reactions in pigs. This was achieved by two independent approaches: (i) changing particle geometry from a spherical shape (which trigger cardiopulmonary distress) to either rod- or disk-shape morphology and (ii) by physically adhering spheres to the surface of erythrocytes. These approaches bypasses particle surface engineering approaches to prevent robust macrophage recognition as well as the use of immunological or pharmacological modulators to reduce/overcome nanomedicine related adverse cardiopulmonary distress