Detection of man-made structures in aerial imagery using quasi-supervised learning and texture features

Thesis (Master)--Izmir Institute of Technology, Electronics and Communication Engineering, Izmir, 2010Includes bibliographical references (leaves: 59-61)Text in English; Abstract: Turkish and Englishx, 61 leavesIn this thesis, the quasi-supervised statistical learning algorithm has been applied for texture recognitioning analysis. The main objective of the proposed method is to detect man-made objects or differences on the terrain as a result of habitating. From this point of view, gaining information about human presence in a region of interest using aerial imagery is of vital importance. This task is adressed using a machine learning paradigm in a quasi-supervised learning. Eigthteen different sized aerial images were used in all computations and analysis. The available data was divided into a reference control set which consist of normalcy condition samples with no human presence, and a mixed testing data set which consisting images of habitate and cultivated terrain. Grey level co-occurrence matrices were then computed for each block and .Haralick Features. were extracted and organized into a texture vector. The quasi-supervised learning was then applied to the collection of texture vectors to identify those image blocks which show human presence in the test data set. In the performance evaluatian part, detected abnormal areas were compared with manually labeled data to determine the corresponding reciever operating characteristic curve. The results showed that the quasi-supervised learning algorithm is able to identify the indicators of human presence in a region such as houses, roads and objects that are not likely to be observed in areas free from human habitation

Clinical outcomes and treatment patterns of primary central nervous system lymphoma: Multicenter retrospective analysis

Objectives: Primary central nervous system lymphoma (PCNSL) is a rare malignant disease with poor prognosis. Its low incidence leads to challenges in decision-making for treatment. As a matter of fact, there is still no consensus on the appropriate treatment modalities. In this context, the objective of this study is to investigate and comparatively assess the efficacies of several treatment modalities in the treatment of PCNSL. Methods: Thirty-four patients diagnosed with PCNSL at 5 different hematology centers between 2007 and 2021 were included in the study. Patients’ data from all five centers were collected retrospectively. Since ibrutinib is not approved for this indication in Turkey, consent for off-label use of ibrutinib is obtained from each patient. Ethics committee ap-proval was obtained on June 9, 2021 with decision number 2021/18-05. Results: The median age of the patients was 59 (min.: 22, max.: 78) years. The male-to-female ratio was 1.26/1. Nineteen (55.9%) patients had Eastern Cooperative Oncology Group (ECOG) performance score of ≥2. Fifteen (44.1%) patients had normal lactate dehydrogenase (LDH) levels and only 14.7% of the patients had B symptoms at the time of diagnosis. Magnetic resonance imaging (MRI) revealed a single mass lesion in 14 (41.2%) patients. As an induction therapy, meth-otrexate-based regimen was administered in 29 (85.3%) patients. Only 14 of the 34 patients received 4 or more cycles of high-dose methotrexate (MTX). About 32.4% of the patients received radiation therapy (RT) during follow-up as a part of induction therapy. Five patients received only RT due to poor performance status. Ibrutinib was administered in 5 patients for refractory disease. It was determined that four or more cycles of MTX treatment increased progression-free survival (PFS) (p=0.031) and overall survival (OS) (p=0.012). Moreover, RT improved PFS (p=0.023). Considering that the complete response achieved by induction therapy influences long-term survival, achievement of the best response to the treatment regimens administered in combination with new agents may prolong survival (PFS: p=0.01, OS: p=0.023). Conclusion: The findings of this study indicate that the initial response to treatment is crucial. Additionally, it was found that high-dose MTX treatment should be administered for 4 cycles or more in order to achieve the best results. Furthermore, it was determined that ibrutinib monotherapy was well-tolerated in our patients with relapsed/refractory disease, with excellent clinical benefits. In conclusion, a combination therapy consisting of high-dose MTX, ibrutinib, and rituximab appears to be a promising initial treatment approach in appropriate patients

Interview with Marjorie Harkins Buchanan Kiewit

In this interview with Julia Stringfellow, Marjorie Harkins Buchanan Kiewit, LU class of 1943, discusses her time as a student as well as her time on the Board of Trustees.https://lux.lawrence.edu/oralhistories/1036/thumbnail.jp

Detection of man-made structures in aerial imagery using quasi-supervised learning and texture features

Thesis (Master)--Izmir Institute of Technology, Electronics and Communication Engineering, Izmir, 2010Includes bibliographical references (leaves: 59-61)Text in English; Abstract: Turkish and Englishx, 61 leavesIn this thesis, the quasi-supervised statistical learning algorithm has been applied for texture recognitioning analysis. The main objective of the proposed method is to detect man-made objects or differences on the terrain as a result of habitating. From this point of view, gaining information about human presence in a region of interest using aerial imagery is of vital importance. This task is adressed using a machine learning paradigm in a quasi-supervised learning. Eigthteen different sized aerial images were used in all computations and analysis. The available data was divided into a reference control set which consist of normalcy condition samples with no human presence, and a mixed testing data set which consisting images of habitate and cultivated terrain. Grey level co-occurrence matrices were then computed for each block and .Haralick Features. were extracted and organized into a texture vector. The quasi-supervised learning was then applied to the collection of texture vectors to identify those image blocks which show human presence in the test data set. In the performance evaluatian part, detected abnormal areas were compared with manually labeled data to determine the corresponding reciever operating characteristic curve. The results showed that the quasi-supervised learning algorithm is able to identify the indicators of human presence in a region such as houses, roads and objects that are not likely to be observed in areas free from human habitation

Histopathologically and by mri the evaluation of effectiveness of different liquid solitions to decrease the carbonization from the thermal effect during liver RF ablation aplications; EX VİVO

Tıpta Uzmanlık TeziÇalışmamızda değişik sıvı solüsyonları kullanarak, radyofrekans ablasyon için sınırlayıcı olan karbonlaşmanın ortadan kaldırılması ve ablasyon sahasının genişletilmesi amaçlandı. Çalışma kapsamında taze kesilmiş sığır karaciğerini 10 cm çaplarında 36 adet blok halinde kesip, 5 farklı sıvı solüsyonu kullanarak perfüze tip multipolar probla radyofrekans ablasyona tabii tuttuk. Ablasyon işlemi sonrası 30. sn'de doku sıcaklığı, işlem sırasında en son izlenen doku direnci, makroskopik ve T2 ağırlıklı manyetik rezonans görüntülerinde ablasyon hacimleri, karbonlaşma varlığı kaydedildi. Daha sonra bu verilerin anlamı istatistiksel olarak araştırıldı. Gruplar arasında istatistiksel olarak anlamlı farklılıklar bulundu. Sonuç olarak, multipolar perfüze tip radyofrekans ablasyonda tüm solüsyonlarda karbonlaşma izlenmedi. Doku direncinin çok yüksek ve düşük olduğu durumlarda radyofrekans ablasyon hacmi sınırlanmaktadır . Anahtar kelimeler: Karaciğer, Radyofrekans ablasyon, Multipolar prob, Sıvı solüsyonuAbstractIn our study, we aimed to use different liquid solutions, the radiofrequency ablation, which is limiting fort he elimination of carbonization and ablation area was to expansion. Liver, fresh cut under the work as a block of 10 cm diameter, cut of 36 pieces, 5 different types of liquid solitions perfused using multipolar radiofrequency ablation were able to test probe. Tissue temprature at 30th second after ablation process, the lastest tissue resistance during ablation process, the presence of carbonization, volume on T2-weighted magnetic resonance images and by macroscopic was recorded.Then the meaning of the data were statistically significant. Significant statistical differences were found between groups.In conclusion; type of radiofrequency ablation perfused, carbonization was observed in all liquid solition. Tissue resistance is very high and very low volume of cases is limited radiofrequency ablation.Keywords: Liver, Radiofrequency ablation, Multipolar prob, Liquid solutio

Ülkemizde Agaricus bisporus Mantarları Üretimi Yapan İşletmelerin Karşılaştığı Sorunlar ve Çözüm Önerilerinin Belirlenmesi

Agaricus bisporus, geçmişten günümüze Dünya’da ve Türkiye’de üretimi en fazla yapılan kültür mantarı türlerinden birisidir. Yapılan bu çalışmada, Dünyada ve ülkemizde üretimi en fazla yapılan Agaricus bisporus (Beyaz şapkalı mantar) yenilebilir mantar üreticilerinin karşılaştıkları sorunlar ve bu sorunlara karşı benimsedikleri çözüm önerilerini araştırılmıştır. Çalışma ülkemiz genelinde 18 ilde faaliyet gösteren toplam 26 işletmede yüz yüze ve telefon yoluyla anket çalışması yapılarak gerçekleştirilmiştir. Anket kapsamında, işletmelerin demografik ve diğer bazı özelliklerinin yanı sıra üreticilerin karşılaştıkları sorunlar ve çözüm önerileri ele alınmıştır. Elde dilen sonuçlara göre üreticilerin belirttiği en önemli sorunlar sırasıyla, mantarın hızlı bozunma riskinin olması, mantar miseli (tohumu) çok pahalı olması, enerji maliyetlerinin yüksek olması, sermaye ve eğitim olmaksızın işletme kurulumu, nakliye masraflarının yüksekliği ve örgütsüzlük sorunu olarak sıralanabilir. Üreticilerinin sorunlara karşı alınabilecek en önemli çözüm önerileri ise sırasıyla, mantar satış noktalarında açıkta satmak yerine soğutuculu reyonlarda satışa sunulması, enerji giderlerinin azaltılmasına yönelik önlemler, “Mantar zehirlidir” yargısının ortadan kaldırılmasına yönelik çalışmalar, müteşebbislerin belli bir sermayeye ve eğitime sahip olmaksızın işletme kurulumuna izin verilmemesidir

Nivolumab-induced lichen planus

Introduction:Renal cell carcinomas account for 90% of all malignant neoplasms of the kidney. The most common types of renal cancer in adults are clear cell and papillary renal cell carcinoma; sporadic cases of renal carcinomas containing chromosomal translocations are rare, more usually occurring in children and young adults. Nivolumab (a fully human immunoglobulin G4 PD-1 checkpoint inhibitor antibody) has received the Food and Drug Administration approval for the treatment of metastatic renal cell carcinoma in patients who have received prior antiangiogenic therapy. Skin reactions are the most common side-effects under treatment with anti-PD-1 antibodies and play an important role for patients. Case report:We report a nivolumab-induced lichen planus as an immune-related adverse event in a young woman who was treated for advanced renal cell carcinoma. After the ninth dose of nivolumab treatment, she was consulted to the dermatologist because of skin lesions, and lichen planus was diagnosed.Management and outcome She was treated with topical corticosteroids and clobetasol propionate cream. Her lesions regressed after the local therapy within one month, allowing for uninterrupted nivolumab therapy. Discussion:Skin adverse events are the most common side-effects under immunotherapy and play an important role for patients and usually develop early in the course of treatment. The most frequent skin reactions are rash, pruritus, and vitiligo. Serious skin adverse events are rare and do not usually require dose reductions or treatment discontinuation. We report a nivolumab-induced lichen planus after the ninth dose of nivolumab