Interstellar Polarization in the Taurus Dark Clouds, Wavelength Dependent Position Angles and Cloud Structure Near TMC-1

We use polarimetric observations of two stars (HD29647, HD283809) in the general direction of TMC-1 in the Taurus Dark Cloud to investigate grain properties and cloud structure in this region. We show the data to be consistent with a simple two-component model, in which general interstellar polarization in the Taurus Cloud is produced by a widely distributed cloud component with relatively uniform magnetic field orientation; the light from stars close to TMC-1 suffers additional polarization arising in one (or more) subcloud(s) with larger average grain size and different magnetic field directions compared with the general trend. Towards HD29647, in particular, we show that the unusually low degree of visual polarization relative to extinction is due to the presence of distinct cloud components in the line of sight with markedly different magnetic field orientations. Stokes parameter calculations allow us to separate out the polarization characteristics of the individual components. Results are fit with the Serkowski empirical formula to determine the degree and wavelength of maximum polarization. Whereas lambda_max values in the widely distributed material are similar to the average (0.55um) for the diffuse interstellar medium, the subcloud in line of sight to HD~283809, the most heavily reddened star in our study, has lambda_max approx. 0.73um, indicating the presence of grains about 30% larger than this average. Our model also predicts detectable levels of circular polarization toward both HD~29647 and HD~283809.Comment: 17 pages including 6 figures, LaTeX, to appear in the Astrophysical Journal, vol 48

Maternal postpartum depression is a risk factor for infant emotional variability at 4 months

Maternal postpartum depression (PPD) is a risk for disruption of mother–infant interaction. Infants of depressed mothers have been found to display less positive, more negative, and neutral affect. Other studies have found that infants of mothers with PPD inhibit both positive and negative affect. In a sample of 28 infants of mothers with PPD and 52 infants of nonclinical mothers, we examined the role of PPD diagnosis and symptoms for infants’ emotional variability, measured as facial expressions, vocal protest, and gaze using microanalysis, during a mother–infant face-to-face interaction. PPD symptoms and diagnosis were associated with (a) infants displaying fewer high negative, but more neutral/interest facial affect events, and (b) fewer gaze off events. PPD diagnosis, but not symptoms, was associated with less infant vocal protest. Total duration of seconds of infant facial affective displays and gaze off was not related to PPD diagnosis or symptoms, suggesting that when infants of depressed mothers display high negative facial affect or gaze off, these expressions are more sustained, indicating lower infant ability to calm down and re-engage, interpreted as a disturbance in self-regulation. The findings highlight the importance of not only examining durations, but also frequencies, as the latter may inform infant emotional variability

Inner Segment Remodeling and Mitochondrial Translocation in Cone Photoreceptors in Age-Related Macular Degeneration With Outer Retinal Tubulation

PURPOSE: To quantify impressions of mitochondrial translocation in degenerating cones and to determine the nature of accumulated material in the subretinal space with apparent inner segment (IS)-like features by examining cone IS ultrastructure. METHODS: Human donor eyes with advanced age-related macular degeneration (AMD) were screened for outer retinal tubulation (ORT) in macula-wide, high-resolution digital sections. Degenerating cones inside ORT (ORT cones) and outside ORT (non-ORT cones) from AMD eyes and unaffected cones in age-matched control eyes were imaged using transmission electron microscopy. The distances of mitochondria to the external limiting membrane (ELM), cone IS length, and cone IS width at the ELM were measured. RESULTS: Outer retinal tubulation and non-ORT cones lose outer segments (OS), followed by shortening of IS and mitochondria. In non-ORT cones, IS broaden. Outer retinal tubulation and non-ORT cone IS myoids become undetectable due to mitochondria redistribution toward the nucleus. Some ORT cones were found lacking IS and containing mitochondria in the outer fiber (between soma and ELM). Unlike long, thin IS mitochondria in control cones, ORT and non-ORT IS mitochondria are ovoid or reniform. Shed IS, some containing mitochondria, were found in the subretinal space. CONCLUSIONS: In AMD, macula cones exhibit loss of detectable myoid due to IS shortening in addition to OS loss, as described. Mitochondria shrink and translocate toward the nucleus. As reflectivity sources, translocating mitochondria may be detectable using in vivo imaging to monitor photoreceptor degeneration in retinal disorders. These results improve the knowledge basis for interpreting high-resolution clinical retinal imaging

The Onion Sign in Neovascular Age-Related Macular Degeneration Represents Cholesterol Crystals

PURPOSE: To investigate the frequency, natural evolution, and histologic correlates of layered, hyperreflective, subretinal pigment epithelium (sub-RPE) lines, known as the onion sign, in neovascular age-related macular degeneration (AMD). DESIGN: Retrospective observational cohort study and experimental laboratory study. PARTICIPANTS: Two hundred thirty eyes of 150 consecutive patients with neovascular AMD and 40 human donor eyes with histopathologic diagnosis of neovascular AMD. METHODS: Spectral-domain optical coherence tomography (SD OCT), near-infrared reflectance (NIR), color fundus images, and medical charts were reviewed. Donor eyes underwent multimodal ex vivo imaging, including SD OCT, before processing for high-resolution histologic analysis. MAIN OUTCOME MEASURES: Presence of layered, hyperreflective sub-RPE lines, qualitative analysis of their change in appearance over time with SD OCT, histologic correlates of these lines, and associated findings within surrounding tissues. RESULTS: Sixteen of 230 eyes of patients (7.0%) and 2 of 40 donor eyes (5.0%) with neovascular AMD had layered, hyperreflective sub-RPE lines on SD OCT imaging. These appeared as refractile, yellow-gray exudates on color imaging and as hyperreflective lesions on NIR. In all 16 patient eyes, the onion sign persisted in follow-up for up to 5 years, with fluctuations in the abundance of lines and association with intraretinal hyperreflective foci. Patients with the onion sign disproportionately were taking cholesterol-lowering medications (P=0.025). Histologic analysis of 2 donor eyes revealed that the hyperreflective lines correlated with clefts created by extraction of cholesterol crystals during tissue processing. The fluid surrounding the crystals contained lipid, yet was distinct from oily drusen. Intraretinal hyperreflective foci correlated with intraretinal RPE and lipid-filled cells of probable monocytic origin. CONCLUSIONS: Persistent and dynamic, the onion sign represents sub-RPE cholesterol crystal precipitation in an aqueous environment. The frequency of the onion sign in neovascular AMD in a referral practice and a pathology archive is 5% to 7%. Associations include use of cholesterol-lowering medication and intraretinal hyperreflective foci attributable to RPE cells and lipid-filled cells of monocyte origin

Predictive impact of rare genomic copy number variations in siblings of individuals with autism spectrum disorders.

Identification of genetic biomarkers associated with autism spectrum disorders (ASDs) could improve recurrence prediction for families with a child with ASD. Here, we describe clinical microarray findings for 253 longitudinally phenotyped ASD families from the Baby Siblings Research Consortium (BSRC), encompassing 288 infant siblings. By age 3, 103 siblings (35.8%) were diagnosed with ASD and 54 (18.8%) were developing atypically. Thirteen siblings have copy number variants (CNVs) involving ASD-relevant genes: 6 with ASD, 5 atypically developing, and 2 typically developing. Within these families, an ASD-related CNV in a sibling has a positive predictive value (PPV) for ASD or atypical development of 0.83; the Simons Simplex Collection of ASD families shows similar PPVs. Polygenic risk analyses suggest that common genetic variants may also contribute to ASD. CNV findings would have been pre-symptomatically predictive of ASD or atypical development in 11 (7%) of the 157 BSRC siblings who were eventually diagnosed clinically

OUTER RETINAL TUBULATION IN ADVANCED AGE-RELATED MACULAR DEGENERATION: Optical Coherence Tomographic Findings Correspond to Histology

PURPOSE: To compare optical coherence tomography (OCT) and histology of outer retinal tubulation (ORT) secondary to advanced age-related macular degeneration in patients and in postmortem specimens, with particular attention to the basis of the hyperreflective border of ORT. METHOD: A private referral practice (imaging) and an academic research laboratory (histology) collaborated on two retrospective case series. High-resolution OCT raster scans of 43 eyes (34 patients) manifesting ORT secondary to advanced age-related macular degeneration were compared to high-resolution histologic sections through the fovea and superior perifovea of donor eyes (13 atrophic age-related macular degeneration and 40 neovascular age-related macular degeneration) preserve

Prospects for multiwavelength polarization observations of GRB afterglows and the case GRB 030329

We explore the prospects for simultaneous, broad-band, multiwavelength polarimetric observations of GRB afterglows. We focus on the role of cosmic dust in GRB host galaxies on the observed percentage polarization of afterglows in the optical/near-infrared bands as a function of redshift. Our driving point is the afterglow of GRB 030329, for which we obtained polarimetric data in the R band and K band simultaneously about 1.5 days after the burst. We argue that polarimetric observations can be very sensitive to dust in a GRB host, because dust can render the polarization of an afterglow wavelength-dependent. We discuss the consequences for the interpretation of observational data and emphasize the important role of very early polarimetric follow-up observations in all bands, when afterglows are still bright, to study the physical properties of dust and magnetic fields in high-z galaxies.Comment: accepted for publication in Astronomy & Astrophysic

Hunters and Their Perceptions of Public Access: A View from Afield

Declining hunter participation threatens cultural traditions and public support for conservation, warranting examination of the forces behind the downward trajectory. Access to lands for hunting, an often-cited reason for non participation, may play a critical role in the retention and recruitment of hunters. Meeting the access needs of a diverse hunting constituency requires understanding how hunters use and perceive access opportunities, particularly public-access sites. Given that perceptions of access are entirely place based and degrade with time, traditional postseason survey methods may fail to adequately quantify the value of public access to the hunting constituency. To overcome the potential limitations of postseason surveys, we conducted on-site assessments of hunter perceptions of habitat quality, game abundance, ease of access, and crowding as well as whether the experience met the hunters’ expectations and their likelihood to return to hunt. Over 3 y, we interviewed 3,248 parties of which 71.5% were hunting. Most parties (65.9%) reported having no private access within the region of Nebraska where they were interviewed. Parties (67.6%) were largely limited to two or fewer hunters, most of whom were adult males (84.3%) who were, on average, 41.2 y old. The perception of public-access sites was generally positive, but 43.1% of parties indicated that game abundance was below average despite 59.2% of parties seeing game and 37.3% harvesting at least one animal. Similar to other explorations of hunter satisfaction, we found game abundance, and in particular harvest success, had the most consistent relationship with hunter perception of public access. By surveying multiple types of hunters across sites that encompass a range of social and ecological conditions, we gained a broader understanding of how hunters perceive public access in real time, which will help to inform future management decisions to foster and improve public-access programs

Darwin's Duchenne: Eye constriction during infant joy and distress

Darwin proposed that smiles with eye constriction (Duchenne smiles) index strong positive emotion in infants, while cry-faces with eye constriction index strong negative emotion. Research has supported Darwin's proposal with respect to smiling, but there has been little parallel research on cry-faces (open-mouth expressions with lateral lip stretching). To investigate the possibility that eye constriction indexes the affective intensity of positive and negative emotions, we first conducted the Face-to-Face/Still-Face (FFSF) procedure at 6 months. In the FFSF, three minutes of naturalistic infant-parent play interaction (which elicits more smiles than cry-faces) are followed by two minutes in which the parent holds an unresponsive still-face (which elicits more cry-faces than smiles). Consistent with Darwin's proposal, eye constriction was associated with stronger smiling and with stronger cry-faces. In addition, the proportion of smiles with eye constriction was higher during the positive-emotion eliciting play episode than during the still-face. In parallel, the proportion of cry-faces with eye constriction was higher during the negative-emotion eliciting still-face than during play. These results are consonant with the hypothesis that eye constriction indexes the affective intensity of both positive and negative facial configurations. A preponderance of eye constriction during cry-faces was observed in a second elicitor of intense negative emotion, vaccination injections, at both 6 and 12 months of age. The results support the existence of a Duchenne distress expression that parallels the more well-known Duchenne smile. This suggests that eye constriction-the Duchenne marker-has a systematic association with early facial expressions of intense negative and positive emotion. © 2013 Mattson et al

A guided tour of asynchronous cellular automata

Research on asynchronous cellular automata has received a great amount of attention these last years and has turned to a thriving field. We survey the recent research that has been carried out on this topic and present a wide state of the art where computing and modelling issues are both represented.Comment: To appear in the Journal of Cellular Automat