What works for knowledge brokers? Assessing the communication challenge of linking research to policy.

Across universities and other research institutions, knowledge brokers play an important role in linking researchers to potential users of their research. Reporting on a recent survey, Sandra Messenger and Sarah Foxen highlight the challenges that knowledge brokers face and how, as a community of experts, open conversations on communication strategies may help stimulate personal reflection and input into individual and collective approaches to widening researcher awareness of policy engagement opportunities

Host redshifts from gravitational-wave observations of binary neutron star mergers

Inspiralling compact binaries as standard sirens will soon become an invaluable tool for cosmology when advanced interferometric gravitational-wave detectors begin their observations in the coming years. However, a degeneracy in the information carried by gravitational waves between the total rest-frame mass $M$ and the redshift $z$ of the source implies that neither can be directly extracted from the signal, but only the combination $M(1+z)$, the redshifted mass. Recent work has shown that for binary neutron star systems, a tidal correction to the gravitational-wave phase in the late-inspiral signal that depends on the rest-frame source mass could be used to break the mass-redshift degeneracy. We propose here to use the signature encoded in the post-merger signal to deduce the redshift to the source. This will allow an accurate extraction of the intrinsic rest-frame mass of the source, in turn permitting the determination of source redshift and luminosity distance solely from gravitational-wave observations. This will herald a new era in precision cosmography and astrophysics. Using numerical simulations of binary neutron star mergers of very slightly different mass, we model gravitational-wave signals at different redshifts and use Bayesian parameter estimation to determine the accuracy with which the redshift can be extracted for a source of known mass. We find that the Einstein Telescope can determine the source redshift to $sim 10$--$20$ at redshifts of $z<0.04$.Comment: 10 pages, 4 figures; same as the version before except for acknowledgment

Metagenomic domain substitution for the high-throughput creation of non-ribosomal peptide analogues

Please click Additional Files below to see the full abstract

Identifying and assessing effectiveness of alternative low-effort nitrogen footprint reductions in small research institutions

© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Messenger, S., Lloret, J., Galloway, J. N., & Giblin, A. Identifying and assessing effectiveness of alternative low-effort nitrogen footprint reductions in small research institutions. Environmental Research Letters, 16(3), (2021): 035014, https://doi.org/10.1088/1748-9326/abd9f6.Concern over the ecological damage of excess nitrogen has brought increased attention to the role of research institutions and universities in contributing to this problem. Institutions often utilize the concept of the ecological 'footprint' to quantify and track nitrogen emissions resulting from their activities and guide plans and commitments to reduce emissions. Often, large-scale changes and commitments to reduce nitrogen footprints are not feasible at small institutions due to monetary and manpower constraints. We partnered with managers in the dining and facilities departments at the Marine Biological Laboratory (MBL), a small research institution in Woods Hole, Massachusetts, to develop five low-effort strategies to address nitrogen emissions at the institution using only resources currently available within those departments. Each proposed strategy achieved emissions reductions in their sector and in the overall nitrogen footprint of the MBL. If all modelled strategies are applied simultaneously, the MBL can achieve a 7.7% decrease in its nitrogen footprint. Managers at MBL considered strategies that required no monetary input most feasible. The intersection of carbon and nitrogen emissions also means the modelled strategies had the co-benefit of reducing the MBL's carbon footprint, strengthening the argument for applying these strategies. This paper may serve as a model for similar institutions looking to reduce the ecological impact of their activities.The work of the Nitrogen Footprint Tool Network was supported by Cooperative Agreement No. 83563201 awarded by the U.S. Environmental Protection Agency

Living in Your Letters: Assessing Congruence Between Espoused and Enacted Values of One Fraternity/Sorority Community

Fraternity and sorority members have long been charged with fulfilling the espoused values of their organizations. Although several studies have explored the gap between the actions and values of undergraduate fraternal members and their institutions, few have examined the degree to which the publicly stated values of fraternal organizations are enacted by members. Using qualitative methodology, researchers compared the creeds and mission statements of undergraduate fraternal organizations to member actions observed on the campus transit system. Results indicated that while there is some congruence between organizational and institutional values and member actions, there are also areas of disconnect for members related to their values

Evaluation of an artificial intelligence enhanced application for student wellbeing: pilot randomised trial of the mind tutor

There has been an increase in the number of UK university students disclosing mental health conditions in recent years. This paper describes the evaluation of the Mind Tutor app, an artificial intelligence based wellbeing app specifically designed for first year undergraduate students, which included a chatbot function that guided students to relevant wellbeing content. The content of the app was developed based on data about mental health and wellbeing issues reported by students and focussed on anxiety, low mood, academic study, transition to university and relationships. Two randomised controlled evaluation studies were conducted with N = 177 and N = 240 first year undergraduate students from two UK universities (the second due to delays in development work and difficulties with recruitment in the first trial). The Mind Tutor had no significant impact on student wellbeing. The study suffered from poor recruitment and retention rates. However, further research is warranted to understand factors that may increase engagement and acceptability of app based tools to increase student wellbeing

Identification and characterisation of mutations associated with von Willebrand disease in a Turkish patient cohort

Several cohort studies have investigated the molecular basis of von Willebrand disease (VWD); however, these have mostly focused on European and North American populations. This study aimed to investigate mutation spectrum in 26 index cases (IC) from Turkey diagnosed with all three VWD types, the majority (73%) with parents who were knowingly related. IC were screened for mutations using multiplex ligation-dependent probe amplification and analysis of all von Willebrand factor gene (VWF) exons and exon/intron boundaries. Selected missense mutations were expressed in vitro. Candidate VWF mutations were identified in 25 of 26 IC and included propeptide missense mutations in four IC (two resulting in type 1 and two in recessive 2A), all influencing VWF expression in vitro. Four missense mutations, a nonsense mutation and a small in-frame insertion resulting in type 2A were also identified. Of 15 type 3 VWD IC, 13 were homozygous and two compound heterozygous for 14 candidate mutations predicted to result in lack of expression and two propeptide missense changes. Identification of intronic breakpoints of an exon 17–18 deletion suggested that the mutation resulted from non-homologous end joining. This study provides further insight into the pathogenesis of VWD in a population with a high degree of consanguineous partnerships