305 research outputs found
Ethnic parity in labour market outcomes for benefit claimants
A significant gap exists in the UK between the employment rate for Ethnic Minorities and that for
Whites. From a policy perspective, it is important to know whether this gap is due to differences in
the characteristics of White and Ethnic Minority groups (which reduce the employability of Ethnic
Minority groups relative to Whites) or whether it results from some form of discriminatory behaviour
in the labour market. In this paper, we use administrative data to estimate ethnic differences in
employment and benefit receipt amongst individuals who began claiming a Jobcentre Plus benefit
in 2003. In contrast to much of the previous UK literature, we use a number of different quantitative
techniques to estimate this gap, and show that in a lot of cases the estimates obtained are very
sensitive to the techniques used. We argue that for the questions we are interested in and the data
we have, propensity score matching methods are the most robust approach to estimating ethnic
parity. We compare this preferred approach with estimates derived using alternative approaches
commonly used in the literature (generally regression-based techniques) to determine the extent to
which more straightforward methods are able to replicate those produced by matching. In many
cases, it turns out not to be possible to calculate satisfactory quantitative estimates even with
matching techniques: the characteristics of Whites and Ethnic Minorities are simply too different
before the Jobcentre Plus intervention to reliably estimate the parameters of interest. Moreover, for
a number of the groups, results seem to be very sensitive to the methodology used. This calls into
question previous results based on simple regression techniques, which are likely to hide the fact
that observationally different ethnic groups are de facto being compared on the basis of parametric
extrapolations. Two groups for which it was possible to calculate reasonably reliable results are
incapacity benefit (IB) and income support (IS). For these groups we find that large and significant
raw penalties almost always disappear once we appropriately control for pre-inflow background
and labour market characteristics. There is also a good degree of consistency across
methodologies
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Household Responses to Information on Child Nutrition: Experimental Evidence from Malawi
Incorrect knowledge of the health production function may lead to inefficient household choices, and thereby to the production of suboptimal levels of health. This paper studies the effects of a randomized intervention in rural Malawi which, over a six-month period, provided mothers of young infants with information on child nutrition without supplying any monetary or in-kind resources. A simple model first investigates theoretically how nutrition and other household choices including labor supply may change in response to the improved nutrition knowledge observed in the intervention areas. We then show empirically that the intervention improved child nutrition, household food consumption and consequently health. We find evidence that labor supply increased, which might have contributed to partially fund the increase in food consumption. This paper is the first to establish that non-health choices, particularly parental labor supply, are affected by parentsâ knowledge of the child health production function
Precautionary recapitalisations under the Bank Recovery and Resolution Directive: conditionality and case practice
Complexity of Bradley-Manna-Sipma Lexicographic Ranking Functions
In this paper we turn the spotlight on a class of lexicographic ranking
functions introduced by Bradley, Manna and Sipma in a seminal CAV 2005 paper,
and establish for the first time the complexity of some problems involving the
inference of such functions for linear-constraint loops (without precondition).
We show that finding such a function, if one exists, can be done in polynomial
time in a way which is sound and complete when the variables range over the
rationals (or reals). We show that when variables range over the integers, the
problem is harder -- deciding the existence of a ranking function is
coNP-complete. Next, we study the problem of minimizing the number of
components in the ranking function (a.k.a. the dimension). This number is
interesting in contexts like computing iteration bounds and loop
parallelization. Surprisingly, and unlike the situation for some other classes
of lexicographic ranking functions, we find that even deciding whether a
two-component ranking function exists is harder than the unrestricted problem:
NP-complete over the rationals and -complete over the integers.Comment: Technical report for a corresponding CAV'15 pape
Th17 Cell Response in SOD1G93A Mice following Motor Nerve Injury
An increased risk of ALS has been reported for veterans, varsity athletes, and professional football players. The mechanism underlying the increased risk in these populations has not been identified; however, it has been proposed that motor nerve injury may trigger immune responses which, in turn, can accelerate the progression of ALS. Accumulating evidence indicates that abnormal immune reactions and inflammation are involved in the pathogenesis of ALS, but the specific immune cells involved have not been clearly defined. To understand how nerve injury and immune responses may contribute to ALS development, we investigated responses of CD4(+) T cell after facial motor nerve axotomy (FNA) at a presymptomatic stage in a transgenic mouse model of ALS (B6SJL SOD1(G93A)). SOD1(G93A) mice, compared with WT mice, displayed an increase in the basal activation state of CD4(+) T cells and higher frequency of Th17 cells, which were further enhanced by FNA. In conclusion, SOD1(G93A) mice exhibit abnormal CD4(+) T cell activation with increased levels of Th17 cells prior to the onset of neurological symptoms. Motor nerve injury exacerbates Th17 cell responses and may contribute to the development of ALS, especially in those who carry genetic susceptibility to this disease
Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst
The CLIP biosensor reveals the spatiotemporal activity of the Nodal proprotein convertases Furin and Pace4 during embryonic development
Rattling Europeâs ordoliberal âiron cageâ : the contestation of austerity in Southern Europe
This article explains the popular revolt against austerity in Southern Europe as the outcome of profound politico-economic changes that are shaped by the transformation of the European Unionâs (EUâs) macro-economic governance. It comprises three parts. The first part demonstrates how ordoliberalism â the Germanic variant of (neo)liberal economic thinking â was embedded in the EUâs new macro-economic governance, in processes that constitutionalise austerity and remove democratic controls over the economy. The second part examines the impact of austerity-driven reforms on welfare and employment in the aftermath of the sovereign debt crisis. These reforms undermined the social reproduction of Southern Europeâs familistic welfare model by destabilising three key pillars of social protection: employment security for householdsâ primary earners; small property ownership; and pension adequacy. The third part analyses the emergence of anti-austerity social politics in Southern Europe, both parliamentary and grassroots, and assesses their effectiveness in light of the collapse of public trust in both EU and domestic political institutions. The article concludes with our reflections on the fragility of EUâs integration process under the hegemony of ordoliberalism
European Society for Organ Transplantation (ESOT) Consensus Statement on the Role of Pancreas Machine Perfusion to Increase the Donor Pool for Beta Cell Replacement Therapy
The advent of Machine Perfusion (MP) as a superior form of preservation and assessment for cold storage of both high-risk kidneyâs and the liver presents opportunities in the field of beta-cell replacement. It is yet unknown whether such techniques, when applied to the pancreas, can increase the pool of suitable donor organs as well as ameliorating the effects of ischemia incurred during the retrieval process. Recent experimental models of pancreatic MP appear promising. Applications of MP to the pancreas, needs refinement regarding perfusion protocols and organ viability assessment criteria. To address the âRole of pancreas machine perfusion to increase the donor pool for beta cell replacement,â the European Society for Organ Transplantation (ESOT) assembled a dedicated working group comprising of experts to review literature pertaining to the role of MP as a method of improving donor pancreas quality as well as quantity available for transplant, and to develop guidelines founded on evidence-based reviews in experimental and clinical settings. These were subsequently refined during the Consensus Conference when this took place in Prague.</p
Active surveillance in renal transplant patients with prostate cancer: a multicentre analysis
Introduction: Due to medical improvements leading to increased life expectancy after renal transplantation and widened eligibility criteria allowing older patients to be transplanted, incidence of (low-risk) prostate cancer (PCa) is increasing among renal transplant recipients (RTR). It remains to be established whether active surveillance (AS) for PCa represents a safe treatment option in this setting. Therefore, we aim to compare AS discontinuation and oncological outcomes of AS for PCa of RTR vs. non-transplant patients. Methods: Multicentre study including RTR diagnosed with PCa between 2008 and 2018 in whom AS was initiated. A subgroup of non-RTR from the St. Antonius hospital AS cohort was used as a control group. Comparison of RTR vs. non-RTR was performed by 2:1 propensity score matched survival analysis. Outcome measures included tumour progression-free survival, treatment-free survival, metastasis rates, biochemical recurrence rates and overall survival. Patients were matched based on age, year of diagnosis, PSA, biopsy ISUP grade group, relative number of positive biopsy cores and clinical stage. Results: A total of 628 patients under AS were evaluated, including 17 RTRs and 611 non-RTRs. A total of 13 RTR cases were matched with 24 non-RTR cases. Median overall follow-up for the RTR and non-RTR matched cases was, respectively, 5.1 (IQR 3.2â8.7) years and 5.7 (IQR 4.8â8.1) years. There were no events of metastasis and biochemical recurrence among matched cases. The matched-pair analysis results in a 1-year and 5-year survival of the RTR and non-RTR patients were, respectively, 100 vs. 92%, and 39 vs. 76% for tumour progression, 100 vs. 91% and 59 vs. 76% for treatment-free survival and, respectively, 100 vs. 100% and 88 vs. 100% for overall survival. No significant differences in tumour progression-free survival (p = 0.07) and treatment-free survival were observed (p = 0.3). However, there was a significant difference in overall survival comparing both groups (p = 0.046). Conclusions: AS may be carefully considered in RTR with low-risk PCa. In our preliminary analysis, no major differences were present in AS outcomes between RTR and non-RTR. Overall mortality was significantly higher in the RTR subgroup
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