Биология. Практикум

УЧЕБНЫЕ ПОСОБИЯБИОЛОГИЯПРАКТИКУМЫГРИБЫРАСТЕНИЯЖИВОТНЫЕМИКОТОКСИНЫ /ФАРМАКОЛОГИЯОНТОГЕНЕЗРАСТЕНИЯ ЯДОВИТЫЕЖИВОТНЫЕ ЯДОВИТЫЕЛАБОРАТОРНЫЕ РАБОТЫТОКСИНЫ /ФАРМАКОЛОГИЯВ практикуме рассматриваются вопросы в соответствии с уровнями организации живого, что позволяет студенту понять процессы, происходящие в человеческом организме на уровне молекул, клеток и организма в целом. Отражены вопросы о ядовитых грибах, растениях и животных, а также применение микотоксинов, фитотоксинов и зоотоксинов как сырья для приготовления фармацевтических препаратов. Издание содержит большинство авторских фотографий микропрепаратов, которые студенты изучают на лабораторных занятиях, приведены тесты для проверки уровня знаний по темам

A New Mesochronous Clocking Scheme for Synchronization in System-on-Chip

All large-scale digital Integrated Circuits need an appropriate strategy for clocking and synchronization. In large-scale and high-speed System-on-Chips (SoC), the traditional"Globally Synchronous"(GS) approach is not longer viable, due to severe wire delays. Instead new solutions as"Globally Synchronous, Locally Asynchronous"(GALS) approaches have been proposed. We propose to replace the GALS approach with a mesochronous clocking principle. In this work, such an approach together with a circuit solution in 0.18mm CMOS process has been presented. This solution allows clocking frequencies up to 4 GHz

A New Mesochronous Clocking Scheme for Synchronization in System-on-Chip

All large-scale digital Integrated Circuits need an appropriate strategy for clocking and synchronization. In large-scale and high-speed System-on-Chips (SoC), the traditional"Globally Synchronous"(GS) approach is not longer viable, due to severe wire delays. Instead new solutions as"Globally Synchronous, Locally Asynchronous"(GALS) approaches have been proposed. We propose to replace the GALS approach with a mesochronous clocking principle. In this work, such an approach together with a circuit solution in 0.18mm CMOS process has been presented. This solution allows clocking frequencies up to 4 GHz

Circuit Techniques for On-Chip Clocking and Synchronization

Today’s microprocessors with millions of transistors perform high-complexity computing at multi-gigahertz clock frequencies. The ever-increasing chip size and speed call for new methodologies in clock distribution network. Conventional global synchronization techniques exhibit many drawbacks in the advanced VLSI chips such as high-speed microprocessors. A significant percentage of the total power consumption in a microprocessor is dissipated in the clock distribution network. Also since the chip dimensions increase, clock skew management becomes very challenging in the framework of conventional methodology. Long interconnect delays limit the maximum clock frequency and become a bottleneck for future microprocessor design. In such a situation, new alternative techniques for synchronization in system-on-chip are demanded. This thesis presents new alternatives for traditional clocking and synchronization methods, in which, speed and power consumption bottlenecks are treated. For this purpose, two new techniques based on mesochronous synchronization and resonant clocking are investigated. The mesochronous synchronization technique deals with remedies for skew and delay management. Using this technique, clock frequency up to 5 GHz for on-chip communication is achievable in 0.18-μm CMOS process. On the other hand the resonant clocking solves significant power dissipation problem in the clock network. This method shows a great potential in power saving in very large-scale integrated circuits. According to measurements, 2.3X power saving in clock distribution network is achieved in 130-nm CMOS process. In the resonant clocking, oscillator plays a crucial role as a clock generator. Therefore an investigation about oscillators and possible techniques for jitter and phase noise reduction in clock generators has been done in this research framework. For this purpose a study of injection locking phenomenon in ring oscillators is presented. This phenomenon can be used as a jitter suppression mechanism in the oscillators. Also a new implementation of the DLL-based clock generators using ring oscillators is presented in 130-nm CMOS process. The measurements show that this structure operates in the frequency range of 100 MHz-1.5 GHz, and consumes less power and area compared to the previously reported structures. Finally a new implementation of a 1.8-GHz quadrature oscillator with wide tuning range is presented. The quadrature oscillators potentially can be used as future clock generators where multi-phase clock is needed.Report code: LiU-TEK-LIC-2006:22</p

Low-Power Low-Jitter Clock Generation and Distribution

Today’s microprocessors with millions of transistors perform high-complexitycomputing at multi-gigahertz clock frequencies. Clock generation and clockdistribution are crucial tasks which determine the overall performance of amicroprocessor. The ever-increasing power density and speed call for newmethodologies in clocking circuitry, as the conventional techniques exhibit manydrawbacks in the advanced VLSI chips. A significant percentage of the total dynamicpower consumption in a microprocessor is dissipated in the clock distributionnetwork. Also since the chip dimensions increase, clock jitter and skew managementbecome very challenging in the framework of conventional methodologies. In such asituation, new alternative techniques to overcome these limitations are demanded. The main focus in this thesis is on new circuit techniques, which treat thedrawbacks of the conventional clocking methodologies. The presented research in thisthesis can be divided into two main parts. In the first part, challenges in design ofclock generators have been investigated. Research on oscillators as central elements inclock generation is the starting point to enter into this part. A thorough analysis andmodeling of the injection-locking phenomenon for on-chip applications show greatpotential of this phenomenon in noise reduction and jitter suppression. In thepresented analysis, phase noise of an injection-locked oscillator has been formulated.The first part also includes a discussion on DLL-based clock generators. DLLs haverecently become popular in design of clock generators due to ensured stability,superior jitter performance, multiphase clock generation capability and simple designprocedure. In the presented discussion, an open-loop DLL structure has beenproposed to overcome the limitations introduced by DLL dithering around the averagelock point. Experimental results reveals that significant jitter reduction can beachieved by eliminating the DLL dithering. Furthermore, the proposed structuredissipates less power compared to the traditional DLL-based clock generators.Measurement results on two different clock generators implemented in 90-nm CMOSshow more than 10% power savings at frequencies up to 2.5 GHz. In the second part of this thesis, resonant clock distribution networks have beendiscussed as low-power alternatives for the conventional clocking schemes. In amicroprocessor, as clock frequency increases, clock power is going to be thedominant contributor to the total power dissipation. Since the power-hungry bufferstages are the main source of the clock power dissipation in the conventional clock distribution networks, it has been shown that the bufferless solution is the mosteffective resonant clocking method. Although resonant clock distribution shows greatpotential in significant clock power savings, several challenging issues have to besolved in order to make such a clocking strategy a sufficiently feasible alternative tothe power-hungry, but well-understood, conventional clocking schemes. In this part,some of these issues such as jitter characteristics and impact of tank quality factor onoverall performance have been discussed. In addition, the effectiveness of theinjection-locking phenomenon in jitter suppression has been utilized to solve the jitterpeaking problem. The presented discussion in this part is supported by experimentalresults on a test chip implemented in 130-nm CMOS at clock frequencies up to 1.8GHz.Mikroprocessorer till dagens datorer innehåller hundratals miljoner transistorersom utför åtskilliga miljarder komplexa databeräkningar per sekund. I stort settalla operationer i dagens mikroprocessorer ordnas genom att synkronisera demmed en eller flera klocksignaler. Dessa signaler behöver ofta distribueras överhela chippet och driva alla synkroniseringskretsar med klockfrekvenser pååtskilliga miljarder svängningar per sekund. Detta utgör en stor utmaning förkretsdesigners på grund av att klocksignalerna behöver ha en extremt högtidsnoggranhet, vilket blir svårare och svårare att uppnå då chippen blir större.Idealt ska samma klocksignal nå alla synkroniseringskretsar exakt samtidigt föratt uppnå optimal prestanda, avvikelser ifrån denna ideala funktionalitet innebärlägre prestanda. Ytterliggare utmaningar inom klockning av digitala chip, är atten betydande andel av processorns totala effekt förbrukas i klockdistributionen.Därför krävs nya innovativa kretslösningar för att lösa problemen med bådeonoggrannheten och den växande effektförbrukningen i klockdistributionen. att lösa de problem som finns i dagens konventionella kretslösningar förklocksignaler på chip. I den första delen av denna avhandling presenterasforskningsresultat på oscillatorer vilka utgör mycket viktiga komponenter igeneringen av klocksignalerna på chippen. Teoretiska studier avfaslåsningsfenomen i integrerade klockoscillatorer har presenterats. Studiernahar visat att det finns stor potential för reducering av tidsonoggrannhet iklocksignalerna med hjälp av faslåsning till en annan signal. I avhandlingensförsta del presenteras även en diskussion om klockgeneratorer baserade påfördröjningslåsta element. Dessa fördröjningslåsta elementen, kända som DLLkretsar, har egenskapen att de kan fördröja en klocksignal med en bestämdfördröjning, vilket möjliggör skapandet av multipla klockfaser. En nykretsteknik har introducerats för klockgenerering av multipla klockfaser vilken reducerar effektförbrukningen och onoggranheten i DLL-baseradeklockgeneratorer. I denna teknik används en övervakningskrets vilken ser till attalla delar i klockgeneratorn utnyttjas effektivt och att oanvända kretsarinaktiveras. Baserat på experimentalla mätresultat från tillverkade testkretsar ikisel har en effektbesparing på mer än 10% uppvisats vid klockfrekvenser påupp till 2.5 GHz tillsammans med en betydande ökning av klocknoggranheten. I avhandlingens andra del diskuteras en klockdistributionsteknik som baseraspå resonans, vilken har visat sig vara ett lovande alternativ till konventionllabufferdrivna klockningstekniker när det gäller minskande effektförbrukning.Principen bakom tekniken är att återanvända den energi som utnyttjas till attladda upp klocklasten. Teoretiska resonemang har visat att storaenergibesparingar är möjliga, och praktiska mätningar på tillverkadeexperimentchip har visat att effektförbrukingen kan mer än halveras. Ettproblem med den föreslagna klockningstekniken är att data som används iberäkningarna kretsen direkt påverkar klocklasten, vilket även påverkarnoggranheten på klocksignalen. För att komma till rätta med detta problemetpresenteras en teknik, baserad på forskning inom ovan nämndafaslåsningsfenomen, som kan minska onoggrannheten på klocksignalen medöver 50%. Både effektbesparingen och förbättringen av tidsnoggranheten harverifierats med hjälp av mätningar på tillverkade chip vid frekvenser upp mot1.8 GHz

Monte Carlo-Free Prediction of Spurious Performance for ECDLL-Based Synthesizers

Misalignment of delay-locked loop (DLL) output edges creates an undesired periodicity, resulting in reference harmonic tones at the output spectrum of edge-combining DLL (ECDLL)-based frequency synthesizers. These spurious tones corrupt the spectral purity to an unacceptable level for wireless applications. The spur magnitude is a random variable defined by the reference frequency, number of DLL phases, harmonic order, stage-delay standard deviation (SD), duty cycle distortion (DCD) of the reference clock, and static phase error (SPE) of the locked-loop due to charge pump/phase detector imperfections. Hence, to estimate the spurious performance of such synthesizers, exhaustive Monte Carlo (MC) simulations are inevitable. Based on closed-form expressions, this paper proposes a generic predictive model for harmonic spur characterization of ECDLL-based frequency synthesizers, whose prediction accuracy is independent of synthesizer design parameters and system non-idealities. Therefore, it can replace MC method to significantly accelerate the iterative design procedure of the synthesizer, while providing comparable predictions in terms of robustness and accuracy to that of MC. Validity, accuracy, and robustness of the proposed prediction method against wide-range values of non-idealities are verified through MC simulations of both the behavioral model and transistor-level model of the synthesizer in a standard 65-nm CMOS technology

Modeling and Analysis of Harmonic Spurs in DLL-Based Frequency Synthesizers

Periodic jitter raises the harmonic spurs at frequency synthesizer output spectrum, down-converting the out-of-band interferers into the desired band and corrupting the wanted signal. This paper proposes a comprehensive behavioral model for spur characterization of edge-combining delay-locked loop (DLL)-based synthesizers, which includes the effects of delay mismatch, static phase error (SPE), and duty cycle distortion (DCD). Based on the proposed model and utilizing Fourier series representation of DLL output phases, an analytical model which formulates the synthesizer spur-to-carrier ratio (SCR) is developed. Moreover, from statistical analysis of the analytical derivations, a closed-form expression for SCR is obtained, from which a spur-aware synthesizer design flow is proposed. Employing this flow and without Monte Carlo (MC) method, one can determine the required stage-delay standard deviation (SD) of a DLL-based synthesizer, at which a certain spurious performance demanded by a target wireless standard is satisfied. A design example is presented which utilizes the proposed design flow to fulfill the SCR requirement of $-$45 dBc for WiMedia-UWB standard. Transistor-level MC simulation of the synthesizer SCR for a standard 65-nm CMOS implementation exhibits good compliance with analytical models and predictions

An 8-GS/s 200-MHz Bandwidth 68-mW ΔΣ DAC in 65-nm CMOS

This brief presents an 8-GS/s 12-bit input ΔΣ digital-to-analog converter (DAC) with 200-MHz bandwidth in 65-nm CMOS. The high sampling rate is achieved by a two-channel interleaved MASH 1–1 digital ΔΣ modulator with 3-bit output, resulting in a highly digital DAC with only seven current cells. The two-channel interleaving allows the use of a single clock for both the logic and the final multiplexing. This requires each channel to operate at half the sampling rate, which is enabled by a high-speed pipelined MASH structure with robust static logic. Measurement results show that the DAC achieves 200-MHz bandwidth, 26-dB SNDR, and $-$57-dBc IMD3, with a power consumption of 68 mW at 1-V digital and 1.2-V analog supplies. This architecture shows potential for use in transmitter baseband for wideband wireless communication.Funding Agencies|Swedish Foundation for Strategic Research (SSF)||</p