The phenolic composition and antioxidant activity of tea with different parts of Sideritis condensate at different steeping conditions

Tea with different parts (flower, leaf, seed) of Sideritis condensate infused at different temperatures (60 and 100°C) and times (5, 10 and 30 minutes) were assessed for their phenolic composition and antioxidant activities. Leaf tea had the highest total phenolic content where as seed tea had the lowest.Leaves soaked at 100°C for 10 minutes had the highest total phenolic content. Total phenolic content of flower tea increased with increase in extraction temperature and time. Radical scavenging activities of leaves infused at 60°C for 5, 10 and 30 minutes were statistically in the same group but lower than those of leaves soaked at 100°C for 5, 10 and 30 min. The major phenolic compound identified from almost all aqueous infusions was the p-coumaric acid. The conditions of tea prepared from leaves of the Sideritis condensata at 100°C for 5, 10 and 30 minutes are the most appropriate conditions in regard to extraction of the highest total phenolics and the strongest antioxidant activity

Effect of IL-1β and IL-1RN polymorphisms in carcinogenesis of the gastric mucosa in patients infected with Helicobacter pylori in Algeria

Background: Infection with Helicobacter pylori is considered a potential risk of developing gastric cancer in association with contributing host genetic factor. IL-1β and IL-1RN polymorphisms appear to maintain and promote Helicobacter pylori infection and to stimulate neoplastic growth of the gastric mucosa.Objective and methods: In order to elucidate the effect of these polymorphisms in combination with gastric cancer in a population from northwestern Algeria, a case-control study was carried out on 79 patients infected with H. pylori with chronic atrophic gastritis and/or gastric carcinoma, and 32 subjects were recruited as casecontrol. IL-1β-31 bi-allelic and IL-1β-511 bi-allelic polymorphisms and IL 1RN penta-allelic were genotyped.Results: IL-1β-31C was associated with an increased risk of developing gastric carcinoma (OR4.614 [1.4314.81], p = 0.01). However, IL-1RN2 heterozygous allele type was significantly associated with chronic atrophic gastritis (OR4.2 [1.233.61], p = 0.022). IL-1β-511T was associated with an increased risk of development of chronic atrophic gastritis (OR4.286 [1.5411.89], p = 0.005).Conclusion: IL-1β and IL-1RN polymorphisms associated with H. pylori infectioncontribute to the development of chronic atrophic gastritis and gastric carcinomas in an Algerian population. The alleles IL-1β-31C and IL-1RN were associated with an increased risk of developing gastric carcinoma, and IL-1β-511T with an increased risk of developing chronic atrophic gastritis with no significant association of developing gastric carcinoma.Keywords: gastric mucosa; Helicobacter pylori; IL-1β; IL-1R

Phenolic compounds of natural knotweed (Polygonum cognatum Meissn.) populations from Turkey

The phenolic compositions of two different Polygonum cognatum samples collected from the Cumra and Manisa regions of Turkey were investigated for the first time. Both tested samples were rich in different phenolic compounds, mostly rutin, isorhamnetin, and catechin. The rutin content of Cumra’s sample was relatively higher than that of Manisa’s sample. P. cognatum has potential regarding rutin content as a functional dietary food or may be used as an ingredient to enrich functional foods. Our study will contribute to the previous works performed by different researchers on P. cognatum, commonly consumed in Turkey, to reveal its beneficial properties

Inadvertent right ventricular apical exit after stereotactic body radiotherapy for ventricular tachycardia: Every cloud has a silver lining

A 78-year-old man suffering from gastric cancer with ischemic cardiomyopathy and recurrent ICD shocks consented to ventricular tachycardia (VT) ablation. He had a previous endocardial VT ablation 1 year ago, and a stereotactic radioablation for his recurrent VT 4 months ago. We planned again left ventricular endocardial mapping for his incessant slow VT suggesting an apical exit site (Figure 1A). However, the activation mapping of LV did not cover the whole VT cycle length, and we decide to map the right ventricular septal side instead of the epicardial access due to the patient's poor frailty. Fortunately, the mid-diastolic potential (MDP) was acquired in an unusual position (Figures 1A and 1B); however, the pericardial location of the mapping catheter was confirmed fluoroscopically (Figures 1C and 1D). An urgent surgical consultation was called for, and operative preparations were initiated. However, since no pericardial tamponade occurred and blood pressure remained stable, we continued the endo-epicardial ablation by ablating the MDP (Video 1)

Transient changes in QRS morphology during a narrow complex tachycardia: What is the mechanism?

A22‐year‐old man with recurrent episodes of tachycardia inthe absence of structural heart disease underwent an electro-physiological evaluation. A narrow complex tachycardia (NCT)was induced by programmed by ventricular pacing. A transientchange in QRS morphology and H‐V interval in the middle of thetracing was noted during ongoing tachycardia (Figure1). What arethepossiblemechanismsoftachycardia and changes in QRS morphology

Investigation of the effect of thymoquinone on kidney damage in isoproterenol-induced myocardial infarction in rats and cardiorenal interactions

This study aimed to determine whether thymoquinone has any protective effects on renal tissue after an isoproterenol-induced myocardial infarction (MI). Experimental groups were formed as 4 groups (n=8). Control group (C). Thymoquinone group (THQ), 20 mg/kg single dose intragastric (i.g.) daily for seven days. Isoproterenol group (ISO) was administered 100 mg/kg intraperitoneally in two doses on days 7 and 8 of the experiment. Thymoquinone+Isoproterenol group (THQ+ISO), THQ 20 mg/kg i.g. was administered once a day for seven days. In addition, two doses of ISO 100 mg/kg i.p. were administered on the seventh and eighth days. Kidney tissues were evaluated histopathologically. Kidney tissues were evaluated histopathologically. Tumour necrosis factor alpha(TNF-α) and alpha Smooth Muscle Actin(α-SMA) immunoreactivity density changes were determined by immunohistochemistry. Glutathione(GST), Glutathione S-transferases(GSTs) and Interleukin-6(IL-6) levels were evaluated by ELISA method. Isoproterenol injection caused severe histopathological changes on kidney tissue. Also TNF-α and α-SMA levels were found to be higher in groups where ISO was administered. THQ could be effective on kidney tissue to partially correct these histopathological damages, by decreasing fibrosis and inflammation. This study shows that treatment with THQ is effective in preventing kidney damage caused by ISO-induced MI. We think that THQ as a supplementary food will be effective to prevent kidney damage

Reply to letter to the editor: '2D LGE or 3D high-resolution LGE: Role of cardiovascular magnetic resonance imaging in the treatment of ventricular arrhythmias'

We are pleased that our paper raised interest among readers of the Anatolian Journal of Cardiology. Even though the late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) imaging was first established for ventricular tissue characterization in localizing ventricular tachycardia (VT) ablation targets (CMR-aided), it is by now widely used as a clinical tool to guide VT ablation (CMR-guided) through the detection of the arrhythmogenic substrate and conducting channels. While the CMR-derived information has been used alongside electroanatomic mapping (EAM) data to aid VT ablation (CMR-aided), the CMR-guided approaches, where EAM acquisition is completely avoided, make procedures faster, and the operator relies solely on imaging data.1 As the authors reported, the analysis of CMR images with software, which is known as ADAS (ADAS 3D, Barcelona, Spain), is very helpful for identifying these conducting channels.2 The preliminary results showed that the mean procedure duration was lower in CMR-guided when compared to CMR-aided and No-CMR substrate ablation (109 ± 61 vs. 206 ± 70 and 233 ± 48 minutes, respectively; P <.001 for both comparisons).1 VOYAGE is a prospective, randomized, multicenter controlled open-label study designed to compare in terms of efficacy, efficiency, and safety of a CMR-aided or guided workflow to standard EAM-guided VT ablation

Cardiac magnetic resonance-guided conducting channel delineation of an aneurysmal ventricular tachycardia with the same circuit in the reverse direction

A 54-year-old male patient with remote inferior wall myocardial infarction with inferoseptal left ventricular (LV) aneurysm (Figure 1A, Video 1) was referred for ablation of hemodynamically tolerated ventricular tachycardia (VT). Image processing (ADAS 3D Galgo Medical, Barcelona, Spain) was used to reconstruct myocardial scar from cardiac magnetic resonance (CMR) and to identify channels of heterogeneous tissue that could be directly involved in the VT reentry circuit (Figure 1B, Videos 2-4). Then, this 3-dimensional (3D) CMR analysis was uploaded into 3D electroanatomic mapping system (CARTO® Biosense Webster Inc., Diamond Bar, CA, USA)

The width of life is more important than the length of life

A 58-year-old man with previous inferior myocardial infarction (MI) was referred for cardiac resynchronization therapy pacemaker (CRT-P) for decreased left ventricular ejection fraction (LVEF; 45%) and left bundle branch block (LBBB) (Figure 1). He had New York Heart Association Class I functional classification but palpitation for 3 months. General physical and cardiac examinations were normal. On the admission day, the electrocardiogram showed a narrow QRS rhythm with and without tachycardia (Figures 2 and 3). Would you recommend or consider a CRT-P device or a CRT defibrillator or only an implantable cardioverter defibrillator (ICD) based on these clinical and electrocardiographic findings, or ablation or medical therapy only

Change in atrial activation patterns during narrow complex tachycardia: What is the mechanism?

A change in the coronary sinus (CS) activation pattern from an eccentric to a concentric pattern during the ablation of an orthodromic reciprocating tachycardia might falsely suggest the presence of a second (septal) accessory pathway (AP) during tachycardia or the successful ablation of the left lateral AP under ventricular pacing despite persistent and unaffected AP conduction. Complete or partial intra-atrial block should be suspected when an abrupt change in the atrial activation sequence is noted during catheter ablation at the posterolateral and lateral aspects of the mitral annulus. The correct anatomical position of the CS catheter plays a vital role in the differential diagnosis of this situation