A comprehensive framework for automotive sustainability assessment

Business efficiency, stakeholder pressure and the need for legislative compliance compel the automotive sector to design and manufacture fuel-efficient, low-impact, environmentally responsible and sustainable vehicles. Managing and responding to these multiple and sometimes conflicting interests requires the measurement of economic, environmental and societal performance. Although a number of automotive sustainability measures are mentioned within the literature, there is no single and unique approach for the complete and integrated sustainability assessment of vehicles. This study has developed a comprehensive automotive sustainability assessment framework by selecting a set of sustainability assessment criteria from the literature and refining these through an interview study with 24 automotive experts from academia, car manufacturers, consultancies and non-governmental organisations. Based on this approach, 26 midpoint and 9 end-point environmental, resource, social and economic impact categories have been identified for the construction of a framework for automotive sustainability assessment. The proposed framework can be used as a decision-supporting tool at the early stages of the vehicle development process. It allows source and sustainability issues to be identified throughout the entire vehicle life cycle and provides the means to sharpen analysis and discussion around these issues. The framework can also serve as a design structure for a wide range of sustainability assessment methods and tools (e.g. multi-criteria decision adding or sustainability accounting methods). It serves as guidance on what needs to be measured in an integrated sustainability assessment of vehicles and leaves the choice of what to include in the decision-making process to the discretion of individual companie

Surface electromyographic control of a novel phonemic interface for speech synthesis

Many individuals with minimal movement capabilities use AAC to communicate. These individuals require both an interface with which to construct a message (e.g., a grid of letters) and an input modality with which to select targets. This study evaluated the interaction of two such systems: (a) an input modality using surface electromyography (sEMG) of spared facial musculature, and (b) an onscreen interface from which users select phonemic targets. These systems were evaluated in two experiments: (a) participants without motor impairments used the systems during a series of eight training sessions, and (b) one individual who uses AAC used the systems for two sessions. Both the phonemic interface and the electromyographic cursor show promise for future AAC applications.F31 DC014872 - NIDCD NIH HHS; R01 DC002852 - NIDCD NIH HHS; R01 DC007683 - NIDCD NIH HHS; T90 DA032484 - NIDA NIH HHShttps://www.ncbi.nlm.nih.gov/pubmed/?term=Surface+electromyographic+control+of+a+novel+phonemic+interface+for+speech+synthesishttps://www.ncbi.nlm.nih.gov/pubmed/?term=Surface+electromyographic+control+of+a+novel+phonemic+interface+for+speech+synthesisPublished versio

From Model Checking to Runtime Verification and Back

We describe a novel approach for adapting an existing software model checker to perform precise runtime verification. The software under test is allowed to communicate with the wider environment (including the file system and network). The modifications to the model checker are small and self-contained, making this a viable strategy for re-using existing model checking tools in a new context. Additionally, from the data that is gathered during a single execution in the runtime verification mode, we automatically re-construct a description of the execution environment which can then be used in the standard, full-blown model checker. This additional verification step can further improve coverage, especially in the case of parallel programs, without introducing substantial overhead into the process of runtime verification

Evolution user requirements for the restructured space station

Space Station Freedom (SSF) is designed to be an Earth orbiting multidisciplinary R&D facility capable of evolving to accommodate a variety of potential uses. In order to identify SSF evolution requirement and define potential growth configurations, NASA-Langley is analyzing user resource requirements for the post-PMC time frame. The analysis goal is to define resource levels, including crew, power, and volume, which allow full utilization of SSF capabilities commensurate with minimum essential user requirements. Multiple scenarios were studied including core R&D and combined SEI plus R&D utilization. An analysis is presented of a core R&D utilization scenario. Included are discussions of resource allocation assumptions for specific R&D disciplines, user requirements trends, and growth resource projections. These preliminary results show total resource requirements of 13 crew, 150 kW power, and additional lab volume equivalent to a second U.S. lab module. Additionally, orthogonal growth structure was identified as required to support SSF systems and users

EphA4 expression promotes network activity and spine maturation in cortical neuronal cultures

<p>Abstract</p> <p>Background</p> <p>Neurons form specific connections with targets via synapses and patterns of synaptic connectivity dictate neural function. During development, intrinsic neuronal specification and environmental factors guide both initial formation of synapses and strength of resulting connections. Once synapses form, non-evoked, spontaneous activity serves to modulate connections, strengthening some and eliminating others. Molecules that mediate intercellular communication are particularly important in synaptic refinement. Here, we characterize the influences of EphA4, a transmembrane signaling molecule, on neural connectivity.</p> <p>Results</p> <p>Using multi-electrode array analysis on <it>in vitro </it>cultures, we confirmed that cortical neurons mature and generate spontaneous circuit activity as cells differentiate, with activity growing both stronger and more patterned over time. When EphA4 was over-expressed in a subset of neurons in these cultures, network activity was enhanced: bursts were longer and were composed of more spikes than in control-transfected cultures. To characterize the cellular basis of this effect, dendritic spines, the major excitatory input site on neurons, were examined on transfected neurons <it>in vitro</it>. Strikingly, while spine number and density were similar between conditions, cortical neurons with elevated levels of EphA4 had significantly more mature spines, fewer immature spines, and elevated colocalization with a mature synaptic marker.</p> <p>Conclusions</p> <p>These results demonstrate that experimental elevation of EphA4 promotes network activity <it>in vitro</it>, supporting spine maturation, producing more functional synaptic pairings, and promoting more active circuitry.</p

Bilateral Diffuse Uveal Melanocytic Proliferation Presenting as Small Choroidal Melanoma

Purpose. To describe a patient with Bilateral Diffuse Uveal Proliferation who presented initially with a clinical picture consistent with choroidal melanoma. Methods. Presentation of a clinical case with fundus photos, fluorescein angiography, and optical coherence tomography. Results. A 70-year-old Caucasian male with history of esophageal cancer presented with an asymptomatic pigmented choroidal lesion in his left eye initially diagnosed as choroidal nevus. This lesion enlarged over the course of a year and developed orange pigment and increased thickness. A metastatic workup was negative, and a radioactive iodine plaque was placed on the left eye. Over the next six months, the visual acuity in his left eye decreased. His clinical picture was consistent with unilateral Diffuse Uveal Proliferation. A recurrence of his esophageal carcinoma with metastasis was discovered and palliative chemotherapy was initiated. Although his visual acuity improved in the left eye, similar pigmentary changes developed in the right fundus. His visual acuity in both eyes gradually decreased to 20/200 until his death a year later. Conclusion. BDUMP should always be considered in the differential diagnosis of patients with pigmented fundus lesions and a history of nonocular tumors

Better than nothing? Patient-delivered partner therapy and partner notification for chlamydia: the views of Australian general practitioners

BACKGROUND Genital chlamydia is the most commonly notified sexually transmissible infection (STI) in Australia and worldwide and can have serious reproductive health outcomes. Partner notification, testing and treatment are important facets of chlamydia control. Traditional methods of partner notification are not reaching enough partners to effectively control transmission of chlamydia. Patient-delivered partner therapy (PDPT) has been shown to improve the treatment of sexual partners. In Australia, General Practitioners (GPs) are responsible for the bulk of chlamydia testing, diagnosis, treatment and follow up. This study aimed to determine the views and practices of Australian general practitioners (GPs) in relation to partner notification and PDPT for chlamydia and explored GPs' perceptions of their patients' barriers to notifying partners of a chlamydia diagnosis. METHODS In-depth, semi-structured telephone interviews were conducted with 40 general practitioners (GPs) from rural, regional and urban Australia from November 2006 to March 2007. Topics covered: GPs' current practice and views about partner notification, perceived barriers and useful supports, previous use of and views regarding PDPT.Transcripts were imported into NVivo7 and subjected to thematic analysis. Data saturation was reached after 32 interviews had been completed. RESULTS Perceived barriers to patients telling partners (patient referral) included: stigma; age and cultural background; casual or long-term relationship, ongoing relationship or not. Barriers to GPs undertaking partner notification (provider referral) included: lack of time and staff; lack of contact details; uncertainty about the legality of contacting partners and whether this constitutes breach of patient confidentiality; and feeling both personally uncomfortable and inadequately trained to contact someone who is not their patient. GPs were divided on the use of PDPT--many felt concerned that it is not best clinical practice but many also felt that it is better than nothing.GPs identified the following factors which they considered would facilitate partner notification: clear clinical guidelines; a legal framework around partner notification; a formal chlamydia screening program; financial incentives; education and practical support for health professionals, and raising awareness of chlamydia in the community, in particular amongst young people. CONCLUSIONS GPs reported some partners do not seek medical treatment even after they are notified of being a sexual contact of a patient with chlamydia. More routine use of PDPT may help address this issue however GPs in this study had negative attitudes to the use of PDPT. Appropriate guidelines and legislation may make the use of PDPT more acceptable to Australian GPs.The Australian Federal Government Department of Health and Ageing Chlamydia Pilot Program of Targeted Grants funded the study

Aberrations of anterior insular cortex functional connectivity in nontreatment-seeking alcoholics

An emergent literature suggests that resting state functional magnetic resonance imaging (rsfMRI) functional connectivity (FC) patterns are aberrant in alcohol use disorder (AUD) populations. The salience network (SAL) is an established set of brain regions prominent in salience attribution and valuation, and includes the anterior insular cortex (AIC). The SAL is thought to play a role in AUD through directing increased attention to interoceptive cues of intoxication. There is very little information on the salience network (SAL) in AUD, and, in particular, there are no data on SAL FC in currently drinking, nontreatment seeking individuals with AUD (NTS). rsfMRI data from 16 NTS and 21 social drinkers (SD) were compared using FC correlation maps from ten seed regions of interest in the bilateral AIC. As anticipated, SD subjects demonstrated greater insular FC with frontal and parietal regions. We also found that, compared to SD, NTS had higher insular FC with hippocampal and medial orbitofrontal regions. The apparent overactivity in brain networks involved in salience, learning, and behavioral control in NTS suggests possible mechanisms in the development and maintenance of AUD

‘Surely a little discretion isn’t too difficult’? The discursive construction of discretion in users’ comments on UK newspaper articles about public breastfeeding

Objective This paper explores how discourses of discretion are constructed in online discussions about breastfeeding in public. Method and Measures We analysed 4204 online newspaper comment threads from 15 UK-based publications using Discursive Psychology. We explored how discretion was constructed and mobilised to facilitate discourses of breastfeeding in public. Results Indiscretion was used to construct dispositional traits of mothers typically associated with sexualised, immoral female behaviour and therefore incompatible with ‘good’ motherhood. Responsibility for preventing public upset was placed on breastfeeding mothers, whilst discretion was constructed as easily achievable, and therefore a reasonable expectation. By implication, women who chose not to be discreet, were constructed as deliberately provocative, and so not entitled to claim or protest negative treatment. Notably, within our data the relevance of discretion when breastfeeding in public appeared discursively difficult to reject or challenge. Conclusion Our findings confirm empirically that support for public breastfeeding is constructed as contingent on mothers displaying discretion. Our analysis highlights the challenges for mothers and babies for whom breastfeeding is compromised by an unwillingness to feed in public, perhaps due to pervasive constructions of breastfeeding women as selfish, exhibitionist, inconsiderate and unfit mothers in public discourse. Finally, our findings demonstrate the practical accomplishment in everyday life of the type of constructions of breastfeeding women that have been powerfully conceptualised by previous researchers