How control systems influence product innovation processes: examining the role of entrepreneurial orientation

This paper yields insights into the channels through which Management Accounting and Control Systems (MACS) exert an influence on product innovation by examining the extent to which different forms of control (i.e. value systems, diagnostic control systems, interactive control systems) are directly associated with the distinct phases of innovation processes. Using survey data collected from 118 medium and large Spanish companies, we find that: (1) value systems and interactive control systems have significant main effects on the creativity, coordination and knowledge integration, and filtering (sub-)phases of innovation processes; and (2) the significance and direction of these influences vary depending on the Entrepreneurial Orientation (EO) of firms. By highlighting the relevance of EO in shaping the influence of MACS on product innovation processes, this study calls for caution in generalising the expected effects of MACS on innovation

Milk composition and production in free-living allied rock-wallabies, Petrogale assimilis

Milk composition and the rates of milk consumption by pouch young were examined in free-living allied rock-wallabies, Petrogale assimilis. Milk solids concentrations were approximately 16% (w/w) at 70 days post-partum and increased to about 22% by 170 days when young first left the pouch. By permanent pouch emergence (about 200 days), concentrations had declined and stabilised at about 19%. Milk carbohydrate peaked at 12% (w/v) at 150 days; lipid concentrations averaged 8% (w/w) at 200 days. The subsequent decline in carbohydrates was the main cause of the fall in milk solids. Protein concentrations increased gradually from about 3% (w/v) at 70 days to plateau at 5.5% at about 200 days. Milk consumption rates were measured from 72 to 159 days post-partum with 22Na turnover. Milk consumption, about 3 mL day- 1 initially, increased to an average of about 15 mL day-1 by 150 days. The mass gained by a pouch young between 72 and 159 days for each millilitre of milk consumed was not correlated with lactational stage and averaged 0.21 ± 0.014 (s.e.) g mL-1

Delayed persistence of giant-nucleated cells induced by X-ray and proton irradiation in the progeny of replicating normal human fibroblast cells

Ionising radiation can induce giant-nucleated cells (GCs) in the progeny of irradiated populations, as demonstrated in various cellular systems. Most in vitro studies have utilised quiescent cancerous or normal cell lines but it is not clear whether radiation-induced GCs persist in the progeny of normal replicated cells. In the current work we show persistent induction of GCs in the progeny of normal human-diploid skin fibroblasts (AG1522). These cells were originally irradiated with a single equivalent clinical dose of 0.2, 1 or 2 Gy of either X-ray or proton irradiation and maintained in an active state for various post-irradiation incubation interval times before they were replated for GC analysis. The results demonstrate that the formation of GCs in the progeny of X-ray or proton irradiated cells was increased in a dose-dependent manner when measured 7 days after irradiation and this finding is in agreement with that reported for the AG1522 cells using other radiation qualities. For the 1 Gy X-ray doses it was found that the GC yield increased continually with time up to 21 days post-irradiation. These results can act as benchmark data for such work and may have important implications for studies aimed at evaluating the efficacy of radiation therapy and in determining the risk of delayed effects particularly when applying protons

Delayed persistence of giant-nucleated cells induced by X-ray and proton irradiation in the progeny of replicating normal human fibroblast cells

Ionising radiation can induce giant-nucleated cells (GCs) in the progeny of irradiated populations, as demonstrated in various cellular systems. Most in vitro studies have utilised quiescent cancerous or normal cell lines but it is not clear whether radiation-induced GCs persist in the progeny of normal replicated cells. In the current work we show persistent induction of GCs in the progeny of normal human-diploid skin fibroblasts (AG1522). These cells were originally irradiated with a single equivalent clinical dose of 0.2, 1 or 2 Gy of either X-ray or proton irradiation and maintained in an active state for various post-irradiation incubation interval times before they were replated for GC analysis. The results demonstrate that the formation of GCs in the progeny of X-ray or proton irradiated cells was increased in a dose-dependent manner when measured 7 days after irradiation and this finding is in agreement with that reported for the AG1522 cells using other radiation qualities. For the 1 Gy X-ray doses it was found that the GC yield increased continually with time up to 21 days post-irradiation. These results can act as benchmark data for such work and may have important implications for studies aimed at evaluating the efficacy of radiation therapy and in determining the risk of delayed effects particularly when applying protons

Mueller Matrix polarization imaging of gastrinoma shows promise for tumor localization

Gastrinomas are gastrin-producing neuroendocrine tumors (NETs) located in the gastroenteropancreatic system. Gastrinomas are often small, multifocal, and found at late stages. Their unpredictable behavior and metastatic potential make it extremely challenging to develop therapeutic strategies. Surgery is the only potentially curative treatment for gastrinoma, but current tumor localization techniques such as intraoperative ultrasound and manual palpitation have poor sensitivity for small tumors, resulting in higher rates of recurrence and metastasis. Therefore, there is a strong clinical need for developing advanced intraoperative imaging technologies for tumor localization in treating gastrinoma. Polarized light imaging (PLI) is a promising method for label-free tissue characterization due to its sensitivity to micro and nanoscale structures, which are often influenced with the onset of cancer, but no works have yet investigated the application of PLI for gastrinoma localization. To assess the suitability of PLI for gastrinoma localization, we imaged 11 formalin-fixed paraffin embedded (FFPE) specimens of gastrinoma using a five-wavelength Mueller Matrix Polarization Microscope. The Lu-Chipman decomposition was applied to spatial maps of the sixteen Mueller matrix parameters. Values for depolarization, diattenuation, and retardance were compared for regions of interest corresponding to tumor and adjacent tissues. There was significant difference between the average depolarization of the Brunner’s gland and tumors when imaged with light at 442, 543, and 632nm (p<0.05), and the average diattenuation values of the two at 405nm (p<0.05), suggesting that these properties could be used for label-free localization. These results motivate further study of the use of PLI for NET localization. Future steps include broadening the sample pool to other NETs and validating results in fresh tissue studies. © 2023 SPIEImmediate accessThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Synergistic use of MERIS and AATSR as a proxy for estimating Land Surface Temperature from Sentinel-3 data

Land Surface Temperature (LST) is one of the key parameters in the physics of land-surface processes on regional and global scales, combining the results of all surface-atmosphere interactions and energy fluxes between the surface and the atmosphere. With the advent of the ESA's Sentinel 3 (S3) satellite, accurate LST retrieval methodologies exploiting the synergy between OLCI and SLSTR instruments can be developed. In this paper we propose a candidate methodology for retrieving LST from data acquired with the forthcoming S3 instruments. The LST algorithm is based on the Split-Window (SW) technique with an explicit dependence on surface emissivity, in contrast to the AATSR level 2 algorithm with emissivity dependence embedded in the algorithm coefficients. Performance of the methodology is assessed by using MERIS/AATSR pairs (instruments with similar characteristics to OLCI and SLSTR, respectively). LST retrievals using different datasets of input emissivity are validated against in situ data measured along one year (2011) in five test sites and intercompared to the standard AATSR level 2 products. Validation results show that LST is retrieved with the proposed SW algorithm typically with RMSE below 2 K, providing slightly better results than the AATSR level 2 product. The main advantage of the proposed algorithm is that it allows for improvements in input emissivities to be directly translated into improved LST retrievals