Performance Practice and Compositional Structure in Relation to Recital Preparation

Master's Project (M.Mu.) University of Alaska Fairbanks, 2017This paper examines the author's graduate percussion recital program; ?Corporel(1985) by Vinko Globokar (b. 1934), Child of Tree (1975) by John Cage (1912-1992) Rebonds b. (1989) by Iannis Xenakis (1992-2001) Ilijas (1996) by Nebojša Jovan Živković (b. 1962), Mourning Dove Sonnet (1983) by Christopher Deane (b. 1957) and e-home (2015/2017) by Elisabet Curbelo (b. 1984). The author offers an examination of performance practice and compositional structure as it relates to the author's performance of the material.Chapter One: ?Corporel (1985) -- Chapter Two: Child of Tree (1975) -- Chapter Three: Rebonds b. (1989) -- Chapter Four: Ilijas (1996) -- Chapter Five: Mourning Dove Sonnet (1983) -- Chapter Six: e-home (2015/2017) -- Work Cited

The role of p53 in atherosclerosis

Although the role of the tumour suppressor gene p53 is well known in cancer, recent studies have highlighted a fundamental role for p53 in regulating cells in the advanced atherosclerotic plaque, the major cause of heart attacks and stroke. In particular, p53 is activated in the complex environment of the plaque, in part by DNA damage within the lesion, and regulates growth arrest, cell senescence and apoptosis of vascular smooth muscle cells (VSMCs). The role of endogenous p53 has been determined using p53 knockout in mice developing advanced atherosclerosis, using bone marrow transplant to separate effects on blood cells from vessel wall cells. These studies have produced apparently contradictory and surprising results. In particular, recent studies have identified a role for endogenous p53 in protection of VSMCs from apoptosis, trans-differentiation of bone marrow stromal cells into VSMCs in atherosclerosis, and altering the mode of cell death in the plaque

Running Economy while Running in Extreme Cushioning and Normal Cushioning Running Shoes

The purpose of the study was to determine if running economy was influenced by wearing maximal cushioning shoes vs. control (neutral cushioning) shoes. (Please see Abstract in text

Accentuate the negative

A survey of mean inequalities with real weights is given.Comment: 16 pages 3 figure

Research on patients with multiple health conditions: different constructs, different views, one voice

Technological advances, improvements in medical care and public health policies have resulted in a growing proportion of patients with multiple health conditions. The prevalence of multiple health conditions among individuals increases with age, is substantial among older adults, and will increase dramatically in coming years. This phenomenon has received growing interest in the most recent literature and has led to several – and often differing – conceptualizations.<p></p> The term “comorbidity” was originally defined by Feinstein as “any distinct additional clinical entity that has existed or may occur during the clinical course of a patient who has the index disease under study”. This definition places one disease in a central position and all other condition(s) as secondary, in that they may or may not affect the course and treatment of the index disease. Feinstein’s principle has been applied all too readily as if the effect of comorbidity was secondary or indeed negligible. In clinical research, individuals with a narrowly defined index condition and no major comorbidities are usually enrolled, leaving the majority of the patients seen in a typical family practice out in the cold. In clinical practice, management of the index condition invariably takes priority, with disjointed – if any – treatment plans developed for each of the comorbidities. This model of care is typical of delivery systems constructed around specialized care, where areas of expertise are defined around specific conditions and bodily systems [11]. Not surprisingly, clinical practice guidelines arising from that model of care lack pertinence for patients with multiple health conditions

General practitioner empathy, patient enablement, and patient-reported outcomes in primary care in an area of high socio-economic deprivation in Scotland - a pilot prospective study using structural equation modelling

<b>Objective</b> The aim of this pilot prospective study was to investigate the relationships between general practitioners (GPs) empathy, patient enablement, and patient-assessed outcomes in primary care consultations in an area of high socio-economic deprivation in Scotland.<p></p> <b>Methods</b> This prospective study was carried out in a five-doctor practice in an area of high socio-economic deprivation in Scotland. Patients’ views on the consultation were gathered using the Consultation and Relational Empathy (CARE) Measure and the Patient Enablement Instrument (PEI). Changes in main complaint and well-being 1 month after the contact consultation were gathered from patients by postal questionnaire. The effect of GP empathy on patient enablement and prospective change in outcome was investigated using structural equation modelling.<p></p> <b>Results</b> 323 patients completed the initial questionnaire at the contact consultation and of these 136 (42%) completed and returned the follow-up questionnaire at 1 month. Confirmatory factor analysis confirmed the construct validity of the CARE Measure, though omission of two of the six PEI items was required in order to reach an acceptable global data fit. The structural equation model revealed a direct positive relationship between GP empathy and patient enablement at contact consultation and a prospective relationship between patient enablement and changes in main complaint and well-being at 1 month.<p></p> <b>Conclusion</b> In a high deprivation setting, GP empathy is associated with patient enablement at consultation, and enablement predicts patient-rated changes 1 month later. Further larger studies are desirable to confirm or refute these findings.<p></p> <b>Practice implications</b> Ways of increasing GP empathy and patient enablement need to be established in order to maximise patient outcomes. Consultation length and relational continuity of care are known factors; the benefit of training and support for GPs needs to be further investigate

Are TIPS really tax disadvantaged? Rethinking the tax treatment of U.S. Treasury Inflation Indexed Securities

In 1997 the U.S. Treasury introduced Inflation Indexed (or Protected) Securities with substantial promotional fanfare. Yet, due in part to what some in the finance profession have described as a "tax disadvantage" placed upon TIPS, many are questioning whether they should appeal to a wide audience. Some, in fact, advise holding TIPS only in tax-deferred accounts. In this paper, the authors develop a framework that allows us to demonstrate that the tax treatment of TIPS is trivially different from that of conventional Treasury securities. Utilizing an after-tax valuation approach, they further show that under relatively conservative projections for inflation, TIPS generally have after-tax yields comparable to, if not exceeding, conventional fixed-rate Treasury securities.Investments ; Taxation ; Securities ; Interest rates ; Income tax

Investigation of effect of propulsion system installation and operation on aerodynamics of an airbreathing hypersonic airplane at Mach 0.3 to 1.2

Results from an investigation of the effects of the operation of a combined turbojet/scramjet propulsion system on the longitudinal aerodynamic characteristics of a 1/60-scale hypersonic airbreathing launch vehicle configuration are presented. Decomposition products of hydrogen peroxide were used for simulation of the propulsion system exhaust

Patient enablement requires physician empathy: a cross-sectional study of general practice consultations in areas of high and low socioeconomic deprivation in Scotland

<b>Background</b> Patient 'enablement' is a term closely aligned with 'empowerment' and its measurement in a general practice consultation has been operationalised in the widely used patient enablement instrument (PEI), a patient-rated measure of consultation outcome. However, there is limited knowledge regarding the factors that influence enablement, particularly the effect of socio-economic deprivation. The aim of the study is to assess the factors influencing patient enablement in GP consultations in areas of high and low deprivation.<p></p> <b>Methods</b> A questionnaire study was carried out on 3,044 patients attending 26 GPs (16 in areas of high socio-economic deprivation and 10 in low deprivation areas, in the west of Scotland). Patient expectation (confidence that the doctor would be able to help) was recorded prior to the consultation. PEI, GP empathy (measured by the CARE Measure), and a range of other measures and variables were recorded after the consultation. Data analysis employed multi-level modelling and multivariate analyses with the PEI as the dependant variable.<p></p> <b>Results</b> Although numerous variables showed a univariate association with patient enablement, only four factors were independently predictive after multilevel multivariate analysis; patients with multimorbidity of 3 or more long-term conditions (reflecting poor chronic general health), and those consulting about a long-standing problem had reduced enablement scores in both affluent and deprived areas. In deprived areas, emotional distress (GHQ-caseness) had an additional negative effect on enablement. Perceived GP empathy had a positive effect on enablement in both affluent and deprived areas. Maximal patient enablement was never found with low empathy.<p></p> <b>Conclusions</b> Although other factors influence patient enablement, the patients' perceptions of the doctors' empathy is of key importance in patient enablement in general practice consultations in both high and low deprivation settings

The fabrication and characterization of stable core-shell superparamagnetic nanocomposites for potential application in drug delivery

Two systems of core-shell superparamagnetic nanoparticles in the size range 45 to 80 nm have been fabricated by the coating of bare magnetite particles with either mesoporous silica or liposomes and the loading/release of the anti-cancer drug Mitomycin C (MMC) from their surfaces has been investigated. The magnetic cores of size ~ 10 nm were produced by a co-precipitation method in aqueous solution, with the silica coating containing an unstructured network of pores of size around 6 nm carried out using a surfactant-templating approach and the liposome coating achieved by an evaporation-immersion technique of the particles in a lipid solution. Stability measurements using a scanning column magnetometry technique indicated that the lipid-coating of the particles halts the sedimentation otherwise apparent in < 1 hour for the bare magnetite to produce an ultra-stable system and thereby overcome one of the main barriers to potential in-vivo applications. Whilst an increase in stability was also observed in the silica-coated system, it was still unstable over a few hours and will require further investigation. Magnetization curves of the coated systems were indicative of superparamagnetic behavior whilst the in vitro loading and release of MMC resulted in two distinctly different outcomes for the two systems: (i) the silica-coated particles saturated in < 4 hours to a loading of around 7 µg/mg of material, releasing about 6 % at a near constant rate over 48 hours whilst (ii) the lipid-coated particles saturated to around only 4 µg/mg over the same time period but with a subsequent rapid release rate over the first 3 hours to 27 % then rising near-linearly to a value of about 45 % at the 48 hour mark. This gives scope for systems’ to be tuned to the appropriate rate and load delivery as required by clinical need with further investigations underway