Running Economy while Running in Extreme Cushioning and Normal Cushioning Running Shoes

The purpose of the study was to determine if running economy was influenced by wearing maximal cushioning shoes vs. control (neutral cushioning) shoes. (Please see Abstract in text

Hypothalamic gene expression during voluntary hypophagia in the Sprague-Dawley rat on withdrawal of the palatable liquid diet, Ensure

Copyright © 2014 Elsevier Inc. All rights reserved.Peer reviewedPostprin

Hydraulic model studies for intake structures for irrigation tunnels 3 and 4

CER70-71AGM9.August 1970.Addendum prepared for Tippetts, Abbett, McCarthy, Stratton.An addendum to the Final report of hydraulic model studies for diversion, power and irrigation tunnels, January 1965

Overground vs. Treadmill Running: Do Runners Use the Same Strategy to Adjust Stride Length and Frequency While Running at Different Velocities?

Running speed is determined by stride frequency and stride length. As running speed is adjusted, runners make greater adjustments in stride length at slower speeds with a shift to stride frequency adjustments at the faster speeds. The relationship between stride frequency and stride length is largely based on overground research which leads to the purpose of this study to analyze whether the connection of stride frequency and stride length will adjust similar due to changes in running velocity during overground and treadmill running. The protocol was recently approved by The Institutional Review Board and data collection is currently in progress; - thus the following present abstract does not contain data. In order to compare runner’s gait pattern responses to velocity changes, two wearable technologies (Garmin Fenix2, Garmin, Kansas, USA; runScribe, Scribe Lab, San Francisco, USA) designed to measure stride length and stride frequency will be utilized. Subjects will run at a variety of velocities overground and then on the treadmill with speeds ranging from slow, preferred, and fast. The main dependent variables will be stride frequency and stride length. The null hypothesis is: The relationship between stride length and stride frequency is similar while running overground and on a treadmill at different velocities. The results of this study will be helpful to runners as well as development of wearable technology used to quantify run metrics

Structural and Signaling Elements Important for the Efficient Degradation of BHMT through Macroautophagy

Healthy cells maintain a dynamic and responsive intracellular environment that is marked by the synthesis and degradation of proteins, complex macromolecules and organelles. Autophagy, literally self-eating, is a mechanism that delivers cellular cargo to the lytic compartment for digestion. Defects in the regulation of autophagy have been implicated in pathologies such as cancer and neurodegenerative disease, making the study of its regulation compelling. However, few studies have looked at the regulation of mammalian autophagy as a function of a specific cargo protein. Previous studies had indicated that the metabolic enzyme betaine homocysteine methyltransferase (BHMT) is degraded through an autophagic mechanism. One aim of this study has centered on the role of BHMT quaternary structure in determining the efficiency of autophagic sequestration and degradation. In these studies, an oligomerization deficient form of BHMT was used to show that modulation of the Class III PI3 kinase signaling pathway is likely involved in discerning monomeric from multimeric BHMT and that this has a role in the subsequent degradation of BHMT by autophagy. The second aim has been to study to role of the nutrient-regulated mTOR pathway in the autophagic degradation of BHMT. It has been proposed that mTOR-mediated inactivation of S6 kinase is required for induction of autophagy in mammals. However in Drosophila melanogaster, S6 kinase activity has been shown to be essential for induction of autophagy. The current study demonstrates that the inhibitory signal from mTOR to autophagy does not go through S6 kinase or subsequent phosphorylation of the ribosomal protein S6. The significance of these observations in terms of misfolded proteins, neurodegenerative diseases and therapeutics is discussed

Alien Registration- Mercer, John A. (Northport, Waldo County)

https://digitalmaine.com/alien_docs/5018/thumbnail.jp

How the implementation of Professional Learning Communities can affect school culture

Dissertation supervisor: Dr. Paul Watkins.Includes vita.This qualitative research piece asks former teachers and administrators of a multibuilding rural district to recall their experiences implementing Professional Learning Communities. Their offerings are compared to established literature in an effort to lend insight into their own processes and procedures and to benefit others who may be considering or revising their own implementation. Topics explored include basic tenets of Professional Learning Communities, best practices in educational leadership, and a sampling of thoughts on change theory. The participants' narratives are woven into a single piece recalling the experience in a single story. Findings and implications are discussed both as anecdotal phenomena and as broader lessons to be learned for other school districts. Recommendations are offered with careful reference to the pertinent literature.Includes bibliographical references (pages 99-102)