20 research outputs found
Enantioselective Synthesis of α-Methylene-ÎČ-hydroxy Carboxylic Acid Derivatives via a Diastereoselective Aldol/ÎČ-Elimination Sequence: Application to the C(15)âC(21) Fragment of Tedanolide C
New Candidaspongiolides, Tedanolide Analogues That Selectively Inhibit Melanoma Cell Growth
Lithothamnin A, the first bastadin-like metabolite from the red alga Lithothamnion fragilissimum.
Lithothamnin A (1) is a new bastadin-like metabolite and represents the first report of this class of molecules from the red alga Lithothamnion fragilissimum. Lithothamnin A contains several novel structural features that distinguish it from other bastadins. These unique structural features include novel aromatic substitution patterns and the presence of a meta-meta linkage between aromatic rings, in addition to the meta-para linkage seen in the bastadins. Lithothamnin A is modestly cytotoxic in a panel of six human tumor cell lines