1,045 research outputs found

    We Thought We Knew the Landscape of Literacy Teacher Education: Ten Surprises From Our Research

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    Vol. 6. No. 2 Nov 2016 In this month's edition of RiTE we are fortunate to have not one but three! Clare Kosnik is Director of the Dr. Eric Jackman Institute of Child Study at the Ontario Institute for Studies in Education, University of Toronto (OISE/UT). Her area of research is teacher education which she has systematically studied. She is now conducting a large-scale study of 28 literacy/English teacher educators in four countries. Lydia Menna is an Assistant Professor of Language and Literacy in the Department of Elementary Education at the University of Alberta. Her research interests are in the areas of teacher education, multiliteracies, critical literacy, and teacher identity construction. She completed her doctorate in the Department of Curriculum, Teaching, and Learning at the Ontario Institute for Studies in Education, University of Toronto. Pooja Dharamshi is an Assistant Professor of Teacher Education in the Faculty of Education at Simon Fraser University. Her research interests are in the areas of critical literacy and teacher education. She recently completed her doctoral studies at the Ontario Institute for Studies in Education/ University of Toronto in the department of Curriculum, Teaching, and Learning. Her study explored the practices and pedagogies of literacy teacher educators with a critical stance

    Anti-CTLA-4 (CD 152) monoclonal antibody-induced autoimmune interstitial nephritis

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    Targeted immune-modulating agents are entering clinical practice in many specialties, providing novel therapeutic possibilities but introducing new potential toxicities. We present the first reported case, to our knowledge, of immune-mediated nephritis following the administration of Tremelimumab (CP-675, 206), an anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) monoclonal antibody. High-dose steroid therapy led to a rapid improvement in renal function, avoiding the need for renal replacement therapy.Peer reviewe

    Methodological and terminological issues in animal-assisted interventions: An umbrella review of systematic reviews

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    Recently, animal-assisted interventions (AAIs), which are defined as psychological, educational, and rehabilitation support activities, have become widespread in different contexts. For many years, they have been a subject of interest in the international scientific community and are at the center of an important discussion regarding their effectiveness and the most appropriate practices for their realization. We carried out an umbrella review (UR) of systematic reviews (SRs), created for the purpose of exploring the literature and aimed at deepening the terminological and methodological aspects of AAIs. It is created by exploring the online databases PubMed, Google Scholar, and Cochrane Library. The SRs present in the high-impact indexed search engines Web of Sciences and Scopus are selected. After screening, we selected 15 SRs that met the inclusion criteria. All papers complained of the poor quality of AAIs; some considered articles containing interventions that did not always correspond to the terminology they have explored and whose operating practices were not always comparable. This stresses the need for the development and consequent diffusion of not only operational protocols, but also research protocols which provide for the homogeneous use of universally recognized terminologies, thus facilitating the study, deepening, and comparison between the numerous experiences described

    H-BIM – Innovative and Digital Tools to Improve the Management of the Existing Buildings

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    With the introduction of the BIM methodology, the digitalization is consolidating mostly the process of new building design defining new standardized working procedures in order to optimize the data flow. On the contrary, pertaining to existing buildings, the rules are still dictated by the traditional methodology leading to fragmented and disaggregated information flow. However, some tools have been recently developed and are quickly upgrading to meet the specific aim to pursue progress, dynamism and experimentation in order to stay in tune with market demands. One common issue, is due to the fact that the documents are paper, hard to find and numerous so that the digitalization represents the best real solution to improve their management. In this regard, the heart of the informative flow is represented by the Common Data Environment (CDE), a cloud storage in which the documents are collected once uploaded and easily manageable with specific platforms. By way of example, a case study is developed in the paper in which the management process of the H-BIM of the XV century’s structure placed in the old town of Naples is carried out in a digital way, through the usBIM.platform (released by ACCA software company) using specific tools, like links, markers and tags. The goal of the paper is to define both a new organization for the data archive, in which the documents are structured and easily traceable, both a new way of conceiving the BIM model that it is thought as an informative vehicle and a key access to the information rather than a mere geometric representation

    Experimental behavior of existing RC columns strengthened with HPFRC jacket under concentric and eccentric compressive load

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    Reinforced concrete (RC) structures built before the 1970 represent a large portion of the existing European buildings stock. Their obsolescence in terms of design criteria, materials, and functionality is becoming a critical issue for guaranteeing adequate compliance with current structural codes. Recently, a new jacketing system based on the use of high-performance fiber-reinforced concrete (HPFRC) has been introduced for strengthening existing RC building members. Despite the promising aspects of the HPFRC jacketing technique, currently, a comprehensive and systematic technical framework for its implementation is still missing. In this paper, the experimental performance of RC columns strengthened with the HPFRC jacket subjected to pure axial load and combined axial load-bending moment uncoupled from shear is investigated. The test outcomes confirmed a significant improvement of the structural performance for the strengthened columns, especially for higher values of eccentricity. Finally, a standard-based practice-oriented analytical tool for designing retrofit interventions using the HPFRC jacket is proposed. The comparison between the calculated and experimental results revealed a satisfactory prediction capability

    Body Temperatures and Activity Patterns of Tasmanian Devils (Sarcophilus harrisii) and Eastern Quolls (Dasyurus viverrinus) through a Subalpine Winter

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    During a field study of carnivorous dasyurid marsupials in subalpine Tasmania, the trapping success for Tasmanian devils (Sarcophilus harrisii), but not for spotted-tailed quolls (Dasyurus maculatus) or eastern quolls (Dasyurus viverrinus), was significantly lower when winter weather conditions turned to sleet or snow or when deep snow lay on the ground. This field study was instigated to determine if devils and eastern quolls spend more time in burrows in severe weather conditions and if they enter torpor. Torpor is known to occur in eutherian mammals as large as devils and in a similar-sized congeneric marsupial, the western quoll (Dasyurus geoffroyi). Using radiotelemetry, body temperatures of Tasmanian devils and eastern quolls ranging freely in their natural habitat were monitored throughout winter. Neither species was observed in torpor, even under prolonged severe weather conditions, and the number of hours spent active did not differ between summer and winter or between moderate and severe winter weather conditions. Body temperatures averaged 36.5 degrees C (SD = 0.079, range of 33.5 degrees -38.6 degrees C) for the three male eastern quolls and 35.7 degrees C (SD = 0.575, range of 31.3 degrees - 37.5 degrees C) for the four (male and female) devils. A diel cycle in body temperature occurred in both species; temperatures rose each evening when animals became active, remained high throughout the night despite ambient temperatures falling to the diel minima, and were lower during the day when the individuals were inactive in dens. The amplitude of this cycle was greater in eastern quolls (1.1 degrees C, SD = 0.142) than in devils (0.6 degrees C, SD = 0.252)

    Managing benign tracheal stenosis during COVID-19 outbreak

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    If elective surgery has been recommended to be postponed some diseases could potentially become life-threatening and cannot be delayed. Among these conditions, tracheal idiopathic stenosis, primary caused by endotracheal intubation or tracheostomy, usually become symptomatic when reach 50% obstruction. Endoscopic procedures could be considered as frst treatment in selected patients after stenosis evaluation, such as non-complex stenosis with low grade of cartilage involvement or tracheomalaci

    Employing Asset Management to Control Costs and Sustain Highway Levels of Service: Volumes I and II

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    This project investigated the impact of varying two elements of pavement, bridge, and mobility asset management on the long term network-level performance of those assets. The first element was the condition at which restorative treatments are triggered. The second element was the budget available to implement these treatments. For each of the pavement, bridge and mobility assets, three different management strategies in the form of treatment trigger values were investigated: a standard treatment trigger strategy, an early treatment trigger strategy, and a late treatment trigger strategy. For the pavement and bridge assets, the standard treatment trigger strategy simulates INDOT’s current treatment trigger policy. The early treatment trigger strategy simulates performing treatment at a better condition level than the standard treatment trigger strategy, while the late treatment trigger strategy simulates deferring treatment to a worse condition level than the standard treatment trigger strategy. For bridge assets, each treatment trigger strategy had six different treatments that can be applied to different bridge components. It was discovered that the standard (current) treatment trigger strategy outperforms other strategies. For pavement assets, the treatment trigger strategies pertained to pavement rehabilitation treatments. It was found that the long-term pavement roughness condition at the network-level is highly influenced by the policy being used to trigger pavement rehabilitation. The higher the trigger standard, the higher the percentage of miles in good condition and the lower the percentage of miles in poor condition. For mobility management, the treatment trigger strategies pertained to lane additions. It was discovered that neither restricting nor expanding the lane addition project candidate list (corresponding to the late and early treatment trigger strategies, respectively) provides more cost efficiency in the long-term for reducing the percent of road miles or VMT experiencing peak hour congestion. The report consists of two volumes; the first volume reports the analysis results for the bridge asset class and the second volume reports the analysis results for the pavement and mobility asset classes

    Migraine and cluster headache show impaired neurosteroids patterns

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    Background: Perturbation of neuronal excitability contributes to migraine. Neurosteroids modulate the activity of γ-aminobutyric acid A and N-methyl-d-aspartate receptors, and might be involved in the pathogenesis of migraine. Here, we measured plasma levels of four neurosteroids, i.e., allopregnanolone, epiallopregnanolone, dehydroepiandrosterone and deydroepiandrosterone sulfate, in patients affected by episodic migraine, chronic migraine, or cluster headache. Methods: Nineteen female patients affected by episodic migraine, 51 female patients affected by chronic migraine, and 18 male patients affected by cluster headache were recruited to the study. Sex- and age-matched healthy control subjects (31 females and 16 males) were also recruited. Patients were clinically characterized by using validated questionnaires. Plasma neurosteroid levels were measured by liquid chromatography-tandem mass spectrometry. Results: We found disease-specific changes in neurosteroid levels in our study groups. For example, allopregnanolone levels were significantly increased in episodic migraine and chronic migraine patients than in control subjects, whereas they were reduced in patients affected by cluster headache. Dehydroepiandrosterone and dehydroepiandrosterone sulfate levels were reduced in patients affected by chronic migraine, but did not change in patients affected by cluster headache. Conclusion: We have shown for the first time that large and disease-specific changes in circulating neurosteroid levels are associated with chronic headache disorders, raising the interesting possibility that fluctuations of neurosteroids at their site of action might shape the natural course of migraine and cluster headache. Whether the observed changes in neurosteroids are genetically determined or rather result from exposure to environmental or intrinsic stressors is unknown. This might also be matter for further investigation because stress is a known triggering factor for headache attacks in both migraineurs and cluster headache patients
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