636 research outputs found
Mapping the potential distribution of the schistosomiasis intermediate host Biomphalaria straminea in China
Biomphalaria straminea is native to Brazil but has established a population in Guangdong Province China. Its potential of expanding and transmitting Schistosoma mansoni is of great concern. We seek to map S. mansoni transmission potential by predicting ecological dimensions and potential distributions of B. straminea using state-of-the-art ecological niche model approaches. Two environmental datasets were selected to fit individual and ensemble niche models, together with the evaluation of niche conservatism during B. straminea invasion in China. A small area is still occupied by the introduced population compared to that in Brazil. A vast space with suitable climate remains unfilled and might be available to B. straminea. Contrasting results of niche conservatism evaluation were attained based on the two environmental datasets. The coastal areas in southern China, together with south-western Yunnan and southern Hainan and Taiwan were consistent supported by multiple model approaches, showing high climate suitability for B. straminea. Attention should be paid to the possibility of S. mansoni epidemic in these identified areas, as high pressure due to propagation and future climate change may further complicate conditions. Our results call for rigorous monitoring and supervising along these areas in China
A Truncated ILâ17RC Peptide Ameliorates Synovitis and Bone Destruction of Arthritic Mice
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134880/1/adhm201600668_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134880/2/adhm201600668-sup-0001-S1.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134880/3/adhm201600668.pd
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Bradyrhizobium diazoefficiens USDA 110âglycine max interactome provides candidate proteins associated with symbiosis
Although the legumeârhizobium symbiosis is a most-important biological process, there is a limited knowledge about the protein interaction network between host and symbiont. Using interolog- and domain-based approaches, we constructed an interspecies protein interactome containing
5115 proteinâprotein interactions between 2291 Glycine max
and 290 Bradyrhizobium diazoefficiens USDA 110 proteins.
The interactome was further validated by the expression
pattern analysis in nodules, gene ontology term semantic
similarity, co-expression analysis, and luciferase complementation image assay. In the G. maxâB. diazoefficiens
interactome, bacterial proteins are mainly ion channel and
transporters of carbohydrates and cations, while G. max
proteins are mainly involved in the processes of metabolism,
signal transduction, and transport. We also identified the top 10 highly interacting proteins (hubs) for each species. Kyoto Encyclopedia of Genes and Genomes pathway analysis for each hub showed that a pair of 14-3-3 proteins (SGF14g and SGF14k) and 5 heat shock proteins in G. max are possibly involved in symbiosis, and 10 hubs in
B. diazoefficiens may be important symbiotic effectors. Subnetwork analysis showed that 18 symbiosis-related soluble
N-ethylmaleimide sensitive factor attachment protein receptor proteins may play roles in regulating bacterial ion channels, and SGF14g and SGF14k possibly regulate the rhizobium dicarboxylate transport protein DctA. The predicted interactome provide a valuable basis for
understanding the molecular mechanism of nodulation in soybean
VideoGLUE: Video General Understanding Evaluation of Foundation Models
We evaluate existing foundation models video understanding capabilities using
a carefully designed experiment protocol consisting of three hallmark tasks
(action recognition, temporal localization, and spatiotemporal localization),
eight datasets well received by the community, and four adaptation methods
tailoring a foundation model (FM) for a downstream task. Moreover, we propose a
scalar VideoGLUE score (VGS) to measure an FMs efficacy and efficiency when
adapting to general video understanding tasks. Our main findings are as
follows. First, task-specialized models significantly outperform the six FMs
studied in this work, in sharp contrast to what FMs have achieved in natural
language and image understanding. Second,video-native FMs, whose pretraining
data contains the video modality, are generally better than image-native FMs in
classifying motion-rich videos, localizing actions in time, and understanding a
video of more than one action. Third, the video-native FMs can perform well on
video tasks under light adaptations to downstream tasks(e.g., freezing the FM
backbones), while image-native FMs win in full end-to-end finetuning. The first
two observations reveal the need and tremendous opportunities to conduct
research on video-focused FMs, and the last confirms that both tasks and
adaptation methods matter when it comes to the evaluation of FMs
Deterministic switching of a perpendicularly polarized magnet using unconventional spinâorbit torques in WTe
Searching for the nano-Hertz stochastic gravitational wave background with the Chinese Pulsar Timing Array Data Release I
Observing and timing a group of millisecond pulsars (MSPs) with high
rotational stability enables the direct detection of gravitational waves (GWs).
The GW signals can be identified from the spatial correlations encoded in the
times-of-arrival of widely spaced pulsar-pairs. The Chinese Pulsar Timing Array
(CPTA) is a collaboration aiming at the direct GW detection with observations
carried out using Chinese radio telescopes. This short article serves as a
`table of contents' for a forthcoming series of papers related to the CPTA Data
Release 1 (CPTA DR1) which uses observations from the Five-hundred-meter
Aperture Spherical radio Telescope (FAST). Here, after summarizing the time
span and accuracy of CPTA DR1, we report the key results of our statistical
inference finding a correlated signal with amplitude \log A_{\rm c}= -14.4
\,^{+1.0}_{-2.8} for spectral index in the range of
assuming a GW background (GWB) induced quadrupolar correlation. The search for
the Hellings-Downs (HD) correlation curve is also presented, where some
evidence for the HD correlation has been found that a 4.6- statistical
significance is achieved using the discrete frequency method around the
frequency of 14 nHz. We expect that the future International Pulsar Timing
Array data analysis and the next CPTA data release will be more sensitive to
the nHz GWB, which could verify the current results.Comment: 18 pages, 6 figures, submitted to "Research in astronomy and
astrophysics" 22nd March 202
Physics case for an LHCb Upgrade II - Opportunities in flavour physics, and beyond, in the HL-LHC era
The LHCb Upgrade II will fully exploit the flavour-physics opportunities of the HL-LHC, and study additional physics topics that take advantage of the forward acceptance of the LHCb spectrometer. The LHCb Upgrade I will begin operation in 2020. Consolidation will occur, and modest enhancements of the Upgrade I detector will be installed, in Long Shutdown 3 of the LHC (2025) and these are discussed here. The main Upgrade II detector will be installed in long shutdown 4 of the LHC (2030) and will build on the strengths of the current LHCb experiment and the Upgrade I. It will operate at a luminosity up to 2Ă1034
cmâ2sâ1, ten times that of the Upgrade I detector. New detector components will improve the intrinsic performance of the experiment in certain key areas. An Expression Of Interest proposing Upgrade II was submitted in February 2017. The physics case for the Upgrade II is presented here in more depth. CP-violating phases will be measured with precisions unattainable at any other envisaged facility. The experiment will probe b â sl+lâand b â dl+lâ transitions in both muon and electron decays in modes not accessible at Upgrade I. Minimal flavour violation will be tested with a precision measurement of the ratio of B(B0 â ÎŒ+ÎŒâ)/B(Bs â ÎŒ+ÎŒâ). Probing charm CP violation at the 10â5 level may result in its long sought discovery. Major advances in hadron spectroscopy will be possible, which will be powerful probes of low energy QCD. Upgrade II potentially will have the highest sensitivity of all the LHC experiments on the Higgs to charm-quark couplings. Generically, the new physics mass scale probed, for fixed couplings, will almost double compared with the pre-HL-LHC era; this extended reach for flavour physics is similar to that which would be achieved by the HE-LHC proposal for the energy frontier
LHCb upgrade software and computing : technical design report
This document reports the Research and Development activities that are carried out in the software and computing domains in view of the upgrade of the LHCb experiment. The implementation of a full software trigger implies major changes in the core software framework, in the event data model, and in the reconstruction algorithms. The increase of the data volumes for both real and simulated datasets requires a corresponding scaling of the distributed computing infrastructure. An implementation plan in both domains is presented, together with a risk assessment analysis
Multidifferential study of identified charged hadron distributions in -tagged jets in proton-proton collisions at 13 TeV
Jet fragmentation functions are measured for the first time in proton-proton
collisions for charged pions, kaons, and protons within jets recoiling against
a boson. The charged-hadron distributions are studied longitudinally and
transversely to the jet direction for jets with transverse momentum 20 GeV and in the pseudorapidity range . The
data sample was collected with the LHCb experiment at a center-of-mass energy
of 13 TeV, corresponding to an integrated luminosity of 1.64 fb. Triple
differential distributions as a function of the hadron longitudinal momentum
fraction, hadron transverse momentum, and jet transverse momentum are also
measured for the first time. This helps constrain transverse-momentum-dependent
fragmentation functions. Differences in the shapes and magnitudes of the
measured distributions for the different hadron species provide insights into
the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb
public pages
Study of the decay
The decay is studied
in proton-proton collisions at a center-of-mass energy of TeV
using data corresponding to an integrated luminosity of 5
collected by the LHCb experiment. In the system, the
state observed at the BaBar and Belle experiments is
resolved into two narrower states, and ,
whose masses and widths are measured to be where the first uncertainties are statistical and the second
systematic. The results are consistent with a previous LHCb measurement using a
prompt sample. Evidence of a new
state is found with a local significance of , whose mass and width
are measured to be and , respectively. In addition, evidence of a new decay mode
is found with a significance of
. The relative branching fraction of with respect to the
decay is measured to be , where the first
uncertainty is statistical, the second systematic and the third originates from
the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb
public pages
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