The Ryanodine Receptor Leak: Its Role in the Development of Heart Failure

The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic reticulum (SR) transmembrane protein that plays a central role in excitation-contraction coupling in cardiomyocytes. Aberrant spontaneous, diastolic Ca2+ leak from the SR due to dysfunctional RyR2 is the mechanism underlying contractile and relaxation dysfunctions in heart failure. Several potential mechanisms have been proposed to explain the dysfunctional RyR2 in heart failure including overphosphorylation status of RyR2, altered RyR2 regulation and perturbed RyR2 intra/intermolecular interactions. Novel therapeutic strategies that enhance myocyte Ca2+ homeostasis could prevent and reverse adverse cardiac remodeling and improve clinical outcomes in patients with heart failure

Thermodynamic Analysis for the Selection of low GWP Refrigerants in Ground Source Heat Pumps

One of the main objectives of the European Commission in the buildings sector, responsible for approximately 40% of total energy consumption and 36% of greenhouse gas emissions, is to identify technological solutions capable of reducing energy consumption and at the same time greenhouse gas emissions. For this purpose, ground source heat pump system (GSHPs) is a technology of particular interest that promises to considerably reduce greenhouse gas emissions of HVAC systems (up to 44% compared to air source heat pumps). In order to develop and test innovative GSHPs to be used for heating and cooling in the various European climatic zones, EU has funded the GEO4CIVHIC project, which will have a duration of 4 years and will end in 2022. As part of the project, the problem of identifying new generation low environmental impact refrigerants to be used in innovative GSHPs is tackled. In this article, we report the results of an energetic and exergetic analysis of the performance of heat pumps based on simulations carried out both on simple reverse cycles and on more complex cycles. Low pressure alternative fluids have been considered as an alternative to R134a and high pressure fluids as an alternative to R410A. The simulations were conducted at various heat sink and heat source temperature conditions, in order to evaluate the GSHPs performance in the whole range of real conditions that can be found in Europe. Particular attention was paid to the compression phase, with the aim to simulate the compressor performance in a more realistic way than simply assuming constant isentropic efficiency

WP2 final report

This document summarises the significant results in work package 2 of the DigiMon project. Detailed descriptions and results from each task can be found in the referenced deliverables and publications

Energetic Analysis of Low Global Warming Potential Refrigerants as Substitutes for R410A and R134a in Ground-Source Heat Pumps

The European building sector is responsible for approximately 40% of total energy consumption and for 36% of greenhouse gas emissions. Identifying technological solutions capable of reducing energy consumption and greenhouse gas emissions is one of the main objectives of the European Commission. Ground source heat pumps (GSHPs) are of particular interest for this purpose, promising a considerable reduction in greenhouse gas emissions of HVAC systems. This paper reports the results of the energetic analysis carried out within the EU research project GEO4CIVHIC about the performance of geothermal heat pumps working with low-GWP refrigerants as alternatives for R134a and R410A. The work has been carried out through computer simulations based on base and regenerative reverse cycles. Several heat sink and heat source temperature conditions have been considered in order to evaluate the GSHPs’ performance in the whole range of real conditions that can be found in Europe. Particular attention has been paid to the evaluation of compression isentropic efficiency and its influence on the overall cycle performance when dealing with steady-state heat pump simulations. To do so, five different scenarios of isentropic efficiency calculation have been studied and discussed