1,376 research outputs found
R-Modes in Superfluid Neutron Stars
The analogs of r-modes in superfluid neutron stars are studied here. These
modes, which are governed primarily by the Coriolis force, are identical to
their ordinary-fluid counterparts at the lowest order in the small
angular-velocity expansion used here. The equations that determine the next
order terms are derived and solved numerically for fairly realistic superfluid
neutron-star models. The damping of these modes by superfluid ``mutual
friction'' (which vanishes at the lowest order in this expansion) is found to
have a characteristic time-scale of about 10^4 s for the m=2 r-mode in a
``typical'' superfluid neutron-star model. This time-scale is far too long to
allow mutual friction to suppress the recently discovered gravitational
radiation driven instability in the r-modes. However, the strength of the
mutual friction damping depends very sensitively on the details of the
neutron-star core superfluid. A small fraction of the presently acceptable
range of superfluid models have characteristic mutual friction damping times
that are short enough (i.e. shorter than about 5 s) to suppress the
gravitational radiation driven instability completely.Comment: 15 pages, 8 figure
The r-modes in accreting neutron stars with magneto-viscous boundary layers
We explore the dynamics of the r-modes in accreting neutron stars in two
ways. First, we explore how dissipation in the magneto-viscous boundary layer
(MVBL) at the crust-core interface governs the damping of r-mode perturbations
in the fluid interior. Two models are considered: one assuming an
ordinary-fluid interior, the other taking the core to consist of superfluid
neutrons, type II superconducting protons, and normal electrons. We show,
within our approximations, that no solution to the magnetohydrodynamic
equations exists in the superfluid model when both the neutron and proton
vortices are pinned. However, if just one species of vortex is pinned, we can
find solutions. When the neutron vortices are pinned and the proton vortices
are unpinned there is much more dissipation than in the ordinary-fluid model,
unless the pinning is weak. When the proton vortices are pinned and the neutron
vortices are unpinned the dissipation is comparable or slightly less than that
for the ordinary-fluid model, even when the pinning is strong. We also find in
the superfluid model that relatively weak radial magnetic fields ~ 10^9 G (10^8
K / T)^2 greatly affect the MVBL, though the effects of mutual friction tend to
counteract the magnetic effects. Second, we evolve our two models in time,
accounting for accretion, and explore how the magnetic field strength, the
r-mode saturation amplitude, and the accretion rate affect the cyclic evolution
of these stars. If the r-modes control the spin cycles of accreting neutron
stars we find that magnetic fields can affect the clustering of the spin
frequencies of low mass x-ray binaries (LMXBs) and the fraction of these that
are currently emitting gravitational waves.Comment: 19 pages, 8 eps figures, RevTeX; corrected minor typos and added a
referenc
r-modes in Relativistic Superfluid Stars
We discuss the modal properties of the -modes of relativistic superfluid
neutron stars, taking account of the entrainment effects between superfluids.
In this paper, the neutron stars are assumed to be filled with neutron and
proton superfluids and the strength of the entrainment effects between the
superfluids are represented by a single parameter . We find that the
basic properties of the -modes in a relativistic superfluid star are very
similar to those found for a Newtonian superfluid star. The -modes of a
relativistic superfluid star are split into two families, ordinary fluid-like
-modes (-mode) and superfluid-like -modes (-mode). The two
superfluids counter-move for the -modes, while they co-move for the
-modes. For the -modes, the quantity is
almost independent of the entrainment parameter , where and
are the azimuthal wave number and the oscillation frequency observed by an
inertial observer at spatial infinity, respectively. For the -modes, on
the other hand, almost linearly increases with increasing . It
is also found that the radiation driven instability due to the -modes is
much weaker than that of the -modes because the matter current associated
with the axial parity perturbations almost completely vanishes.Comment: 14 pages, 4 figures. To appear in Physical Review
Edoxaban: an update on the new oral direct factor Xa inhibitor.
Edoxaban is a once-daily oral anticoagulant that rapidly and selectively inhibits factor Xa in a concentration-dependent manner. This review describes the extensive clinical development program of edoxaban, including phase III studies in patients with non-valvular atrial fibrillation (NVAF) and symptomatic venous thromboembolism (VTE). The ENGAGE AF-TIMI 48 study (N = 21,105; mean CHADS2 score 2.8) compared edoxaban 60 mg once daily (high-dose regimen) and edoxaban 30 mg once daily (low-dose regimen) with dose-adjusted warfarin [international normalized ratio (INR) 2.0-3.0] and found that both regimens were non-inferior to warfarin in the prevention of stroke and systemic embolism in patients with NVAF. Both edoxaban regimens also provided significant reductions in the risk of hemorrhagic stroke, cardiovascular mortality, major bleeding and intracranial bleeding. The Hokusai-VTE study (N = 8,292) in patients with symptomatic VTE had a flexible treatment duration of 3-12 months and found that following initial heparin, edoxaban 60 mg once daily was non-inferior to dose-adjusted warfarin (INR 2.0-3.0) for the prevention of recurrent VTE, and also had a significantly lower risk of bleeding events. Both studies randomized patients at moderate-to-high risk of thromboembolic events and were further designed to simulate routine clinical practice as much as possible, with edoxaban dose reduction (halving dose) at randomisation or during the study if required, a frequently monitored and well-controlled warfarin group, a well-monitored transition period at study end and a flexible treatment duration in Hokusai-VTE. Given the phase III results obtained, once-daily edoxaban may soon be a key addition to the range of antithrombotic treatment options
Second-order rotational effects on the r-modes of neutron stars
Techniques are developed here for evaluating the r-modes of rotating neutron
stars through second order in the angular velocity of the star. Second-order
corrections to the frequencies and eigenfunctions for these modes are evaluated
for neutron star models. The second-order eigenfunctions for these modes are
determined here by solving an unusual inhomogeneous hyperbolic boundary-value
problem. The numerical techniques developed to solve this unusual problem are
somewhat non-standard and may well be of interest beyond the particular
application here. The bulk-viscosity coupling to the r-modes, which appears
first at second order, is evaluated. The bulk-viscosity timescales are found
here to be longer than previous estimates for normal neutron stars, but shorter
than previous estimates for strange stars. These new timescales do not
substantially affect the current picture of the gravitational radiation driven
instability of the r-modes either for neutron stars or for strange stars.Comment: 13 pages, 5 figures, revte
R-mode oscillations and rocket effect in rotating superfluid neutron stars. I. Formalism
We derive the hydrodynamical equations of r-mode oscillations in neutron
stars in presence of a novel damping mechanism related to particle number
changing processes. The change in the number densities of the various species
leads to new dissipative terms in the equations which are responsible of the
{\it rocket effect}. We employ a two-fluid model, with one fluid consisting of
the charged components, while the second fluid consists of superfluid neutrons.
We consider two different kind of r-mode oscillations, one associated with
comoving displacements, and the second one associated with countermoving, out
of phase, displacements.Comment: 10 page
Longitudinal effect of eteplirsen versus historical control on ambulation in Duchenne muscular dystrophy
To continue evaluation of the long-term efficacy and safety of eteplirsen, a phosphorodiamidate morpholino oligomer designed to skip DMD exon 51 in patients with Duchenne muscular dystrophy (DMD). Three-year progression of eteplirsen-treated patients was compared to matched historical controls (HC).
METHODS:
Ambulatory DMD patients who were 657 years old and amenable to exon 51 skipping were randomized to eteplirsen (30/50mg/kg) or placebo for 24 weeks. Thereafter, all received eteplirsen on an open-label basis. The primary functional assessment in this study was the 6-Minute Walk Test (6MWT). Respiratory muscle function was assessed by pulmonary function testing (PFT). Longitudinal natural history data were used for comparative analysis of 6MWT performance at baseline and months 12, 24, and 36. Patients were matched to the eteplirsen group based on age, corticosteroid use, and genotype.
RESULTS:
At 36 months, eteplirsen-treated patients (n = 12) demonstrated a statistically significant advantage of 151m (p < 0.01) on 6MWT and experienced a lower incidence of loss of ambulation in comparison to matched HC (n = 13) amenable to exon 51 skipping. PFT results remained relatively stable in eteplirsen-treated patients. Eteplirsen was well tolerated. Analysis of HC confirmed the previously observed change in disease trajectory at age 7 years, and more severe progression was observed in patients with mutations amenable to exon skipping than in those not amenable. The subset of patients amenable to exon 51 skipping showed a more severe disease course than those amenable to any exon skipping.
INTERPRETATION:
Over 3 years of follow-up, eteplirsen-treated patients showed a slower rate of decline in ambulation assessed by 6MWT compared to untreated matched HC. Ann Neurol 2016;79:257-271
The Advanced LIGO Photon Calibrators
The two interferometers of the Laser Interferometry Gravitaional-wave
Observatory (LIGO) recently detected gravitational waves from the mergers of
binary black hole systems. Accurate calibration of the output of these
detectors was crucial for the observation of these events, and the extraction
of parameters of the sources. The principal tools used to calibrate the
responses of the second-generation (Advanced) LIGO detectors to gravitational
waves are systems based on radiation pressure and referred to as Photon
Calibrators. These systems, which were completely redesigned for Advanced LIGO,
include several significant upgrades that enable them to meet the calibration
requirements of second-generation gravitational wave detectors in the new era
of gravitational-wave astronomy. We report on the design, implementation, and
operation of these Advanced LIGO Photon Calibrators that are currently
providing fiducial displacements on the order of
m/ with accuracy and precision of better than 1 %.Comment: 14 pages, 19 figure
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