3,597 research outputs found
Striatal dopamine D2 receptor binding of risperidone in schizophrenic patients as assessed by 123I-iodobenzamide SPECT: a comparative study with olanzapine
The aim of this investigation was to compare the degree of striatal dopamine-(D2) receptor blockade by two atypical antipsychotic drugs, risperidone and olanzapine. The percentage of D2 receptor occupancy during treatment was calculated by comparing the results of 123I-iodobenzamide SPECT with those from healthy control subjects. Twenty inpatients suffering from schizophrenia or schizoaffective psychosis according to DSM IV/ICD-10 criteria were treated with clinically recommended doses of risperidone and compared with 13 inpatients treated with up to 20 mg olanzapine. Neuroleptic dose and D2 receptor blockade correlated strongly for both risperidone (Pearson r = â0.86, p = 0.0001) and olanzapine (Pearson r = â0.77, p = 0.002). There was no significant difference between the D2 receptor occupancy of the two substances when given in the clinically recommended dose range (unpaired t-test, t= â0.112, p=0.911)
The Radio Afterglow and the Host Galaxy of the X-Ray Rich GRB 981226
We report the discovery of a radio transient VLA 232937.2-235553, coincident
with the proposed X-ray afterglow for the gamma-ray burst GRB 981226. This GRB
has the highest ratio of X-ray to gamma-ray fluence of all the GRBs detected by
BeppoSAX so far and yet no corresponding optical transient was detected. The
radio light curve of VLA 232937.2-235553 is qualitatively similar to that of
several other radio afterglows. At the sub-arcsecond position provided by the
radio detection, optical imaging reveals an extended R=24.9 mag object, which
we identify as the host galaxy of GRB 981226. Afterglow models which invoke a
jet-like geometry for the outflow or require an ambient medium with a radial
density dependence, such as that produced by a wind from a massive star, are
both consistent with the radio data. Furthermore, we show that the observed
properties of the radio afterglow can explain the absence of an optical
transient without the need for large extinction local to the GRB.Comment: Accepted for publication in the Astrophysical Journal Letters.
Thirteen pages. Three Postscript figure
The hidden burden of adult allergic rhinitis : UK healthcare resource utilisation survey
Funding Funding for this survey was provided by Meda Pharma.Peer reviewedPublisher PD
Seismic imaging of the Northern Andean subduction zone from teleseismic tomography: a torn and fragmented Nazca slab
The Nazca-South America subduction zone in Ecuador is characterized by a complicated along-strike geometry as the slab transitions from flat slab subduction in the south, with the Peruvian flat slab, to what has been characterized as ânormalâ dipping subduction beneath central Ecuador. Plate convergence additionally changes south to north as the trench takes on a convex shape. Highly heterogeneous bathymetry at the trench, including the aseismic oceanic
Carnegie Ridge (CR), and sparse intermediate-depth seismicity has led many to speculate about the behaviour of the downgoing plate at depth. In this study, we present a finite-frequency teleseismic P-wave tomography model of the northern Andes beneath Ecuador and Colombia from 90 to 1200 km depth. Our model builds on prior tomography models in South America by adding relative traveltime residuals recorded at stations in Ecuador. The complete
data set is comprised of 114 096 relative traveltime residuals from 1133 stations across South America, with the added data serving to refine the morphology of the Nazca slab in the mantle beneath the northern Andes. Our tomography model shows a Nazca slab with a fragmented along-strike geometry and the first teleseismic images of several proposed slab tears in this region. At the northern edge of the Peruvian flat slab in southern Ecuador, we image a shallow
tear at 95â200 km depth that appears to connect mantle flow from beneath the flat slab to the Ecuadorian Arc. Beneath central Ecuador at the latitudes of the CR, the Nazca slab is continuous into the lower mantle. Beneath southern Colombia, the Malpelo Tear breaks the Nazca slab below âŒ200 km depth
Rapid detection, cloning and molecular cytogenetic characterisation of sequences from an MRP-encoding amplicon by chromosome microdissection.
Chromosome microdissection was utilised for the analysis of cytogenetic markers of gene amplification [homogeneously staining regions (hsrs) and double minutes (dmins)] in two doxorubicin-resistant cell lines, fibrosarcoma HT1080/DR4 and small-cell lung cancer H69AR. Microdissection products from the hsr(7)(p12p15) of HT1080/DR4 were amplified and used for fluorescent in situ hybridisation (micro-FISH) analysis of drug-sensitive HT1080, resistant HT1080/DR4 and normal lymphocytes. The results demonstrated that the hsr contains a domain of DNA amplification of complex origin including sequences derived from 16p11.2-16p13.1, 2q11.2, 7q32-7q34 and 10q22. The amplification was confirmed by converting the micro-dissected probe into a microclone library for probing HT1080 and HT1080/DR4 Southerns. A micro-FISH probe from normal band region 16p11-16p13 further demonstrated amplification of 16p sequences in both HT1080/DR4 and H69AR. During the course of this analysis, Cole et al. (1992) (Science, 258, 1650-1653) published the amplification of the MRP gene in H69AR cells, which maps to chromosome 16p13.1. Our results corroborate the finding of MRP amplification in these doxorubicin-resistant cell lines, but, importantly, they provide information on the composition of the complex amplicon contributions from four different chromosomes. This study demonstrates the potential utility of chromosome microdissection for the rapid recovery of sequences from amplified regions in drug-resistant cells
The construction of social housing pathways across Australia
This report examines the formal social housing pathways set out in policy and how these differ across jurisdictions. It uses a systems thinking approach to examine how actors, levers, feedback loops, incentives and disincentives influence formal social housing pathways. The discussion presents evidence from a comprehensive policy review, as well as data from interviews and a workshop with key stakeholders, including government representatives and community housing managers
Tidal Stabilization of Rigidly Rotating, Fully Relativistic Neutron Stars
It is shown analytically that an external tidal gravitational field increases
the secular stability of a fully general relativistic, rigidly rotating neutron
star that is near marginal stability, protecting it against gravitational
collapse. This stabilization is shown to result from the simple fact that the
energy required to raise a tide on such a star, divided by the
square of the tide's quadrupole moment , is a decreasing function of the
star's radius , (where, as changes, the
star's structure is changed in accord with the star's fundamental mode of
radial oscillation). If were positive, the tidal
coupling would destabilize the star. As an application, a rigidly rotating,
marginally secularly stable neutron star in an inspiraling binary system will
be protected against secular collapse, and against dynamical collapse, by tidal
interaction with its companion. The ``local-asymptotic-rest-frame'' tools used
in the analysis are somewhat unusual and may be powerful in other studies of
neutron stars and black holes interacting with an external environment. As a
byproduct of the analysis, in an appendix the influence of tidal interactions
on mass-energy conservation is elucidated.Comment: Revtex, 10 pages, 2 figures; accepted for publication in Physical
Review D. Revisions: Appendix rewritten to clarify how, in Newtonian
gravitation theory, ambiguity in localization of energy makes interaction
energy ambiguous but leaves work done on star by tidal gravity unambiguous.
New footnote 1 and Refs. [11] and [19
Anisotropic dark energy stars
A model of compact object coupled to inhomogeneous anisotropic dark energy is
studied. It is assumed a variable dark energy that suffers a phase transition
at a critical density. The anisotropic Lambda-Tolman-Oppenheimer-Volkoff
equations are integrated to know the structure of these objects. The anisotropy
is concentrated on a thin shell where the phase transition takes place, while
the rest of the star remains isotropic. The family of solutions obtained
depends on the coupling parameter between the dark energy and the fermion
matter. The solutions share several features in common with the gravastar
model. There is a critical coupling parameter that gives non-singular black
hole solutions. The mass-radius relations are studied as well as the internal
structure of the compact objects. The hydrodynamic stability of the models is
analyzed using a standard test from the mass-radius relation. For each
permissible value of the coupling parameter there is a maximum mass, so the
existence of black holes is unavoidable within this model.Comment: 12 pages, 6 figures, final manuscript, Accepted for publication in
Astrophysics & Space Scienc
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