Rediscover Mogi: Marketing, Communication, and Lovingness for the Recognition of Subjects and Places

The objective of this text is to reflect on the relationship between Marketing, Communication, and lovingness, for the recognition of subjects and places, based on an investigation involving the Rediscover Mogi campaign. It results from ongoing studies at the University of Caxias do Sul, in the Postgraduate Program in Tourism and Hospitality. The city of Mogi das Cruzes, located in the State of São Paulo – Brazil, was chosen as the field of study. In theoretical terms, the text associates studies on Marketing and Communication, in contrast to the capitalistic discussion and the challenges of organizing production and communication more focused on lovingness, as an ethics of care and relation, in line with contemporary demands. The methodological strategy used is the Cartography of Knowledge, proposed by Baptista (2014, 2020a), with investigative actions that include a Bibliographic Survey, Writing Reports by one of the Researchers, and Cartography of Data Related to Mogi and the Rediscover Mogi Campaign. The text flags the potential for reinventing the Marketing-Communication binomial, which can be apprehended by the ‘conversations' of the residents of the Mogi das Cruzes on social networks.   CITE THIS PAPER:Melo, Camila, C.; Baptista, Maria L. C. (2023). “Rediscover Mogi: Marketing, Communication, and Lovingness for the Recognition of Subjects and Places” Journal of Social Sciences: Transformations & Transitions (JOSSTT) 3(06):26. DOI: https://doi.org/10.52459/josstt3626052

Smartphone-based video analysis for guiding shoulder therapeutic exercises: concurrent validity for movement quality control

Neuromuscular re-education through therapeutic exercise has a determinant role in chronic shoulder pain rehabilitation. Smartphones are an interesting strategy to extend the rehabilitation to a home-based scenario as it can increase the attraction and involvement of users by providing feedback. Objective: To analyze the concurrent validity of a smartphone’s application based on 2D video analysis against the gold-standard 3D optoelectronic system for assessing movement quality during upper limb therapeutic exercises. Methods: Fifteen young adults were evaluated while executing two different shoulder exercises with a smartphone’s 2D video and a 3D optoelectronic system simultaneously in two conditions: (1) with the supervision and instructions of a physiotherapist (guided exercise), and (2) without the feedback of the physiotherapist (non-guided exercise). The data obtained during the guided and non-guided exercises were compared to calculate the movement quality index based on the approximation of the non-guided exercise to the guided exercise for the head, trunk, and shoulder’s range of movement. The agreement of the movement quality index assessed with the smartphone application and the optoelectronic system was carried out through Bland–Altman analysis. Results: The Bland–Altman analysis indicates the range of agreement and bias tendency. This tendency demonstrates that the percentage of difference between the two methods increases as the movement quality index decreases. Conclusions: There is agreement between the movement quality evaluated by a gold-standard method and the developed application, although the proposed method appears to have less sensitivity for evaluating movements with lower quality index.info:eu-repo/semantics/publishedVersio

Comparing Mixed & Integer Programming vs. Constraint Programming by solving Job-Shop Scheduling Problems

Scheduling is a key factor for operations management as well as for business success. From industrial Job-shop Scheduling problems (JSSP), many optimization challenges have emerged since de 1960s when improvements have been continuously required such as bottlenecks allocation, lead-time reductions and reducing response time to requests.  With this in perspective, this work aims to discuss 3 different optimization models for minimizing Makespan. Those 3 models were applied on 17 classical problems of examples JSSP and produced different outputs.  The first model resorts on Mixed and Integer Programming (MIP) and it resulted on optimizing 60% of the studied problems. The other models were based on Constraint Programming (CP) and approached the problem in two different ways: a) model CP1 is a standard IBM algorithm whereof restrictions have an interval structure that fail to solve 53% of the proposed instances, b) Model CP-2 approaches the problem with disjunctive constraints and optimized 88% of the instances. In this work, each model is individually analyzed and then compared considering: i) Optimization success performance, ii) Computational processing time, iii) Greatest Resource Utilization and, iv) Minimum Work-in-process Inventory. Results demonstrated that CP-2 presented best results on criteria i and ii, but MIP was superior on criteria iii and iv and those findings are discussed at the final section of this work

Specificity of S '(1) and S '(2) subsites of human tissue kallikrein using the reactive-centre loop of kallistatin: the importance of P '(1) and P '(2) positions in design of inhibitors

We have demonstrated that the S-1' and S-2', subsites of human tissue kallikrein (hK1) play determinant roles in the recognition and hydrolysis of substrates. the presence of serine at position P-1' and arginine at P-2' resulted in the best substrate, Abz-Ala-Ile-Lys-Phe-Phe-Ser-Arg-Gln-EDDnp, which was derived from the kallistatin reactive-centre loop sequence and quencher groups o-aminobenzoic acid (Abz) and N-(2,4-dinitrophenyl)ethylenediamine (EDDnp). Serine and arginine are also the residues at positions P-1' and P-2' in human kininogen, from which hK1 releases Lys-bradykinin. Several peptide analogues of Abz-Ala-Ile-Lys-Phe-Phe-Ser-Arg-Gln-EDDnp, in which the Ser and Arg residues were substituted with various other amino acids, were synthesized and tested as substrates. Most of them were hydrolysed slowly, although they showed significant binding to hK1, as demonstrated by their competitive inhibition constants (K-i). Using this information, six peptides were designed, synthesized and assayed as inhibitors of hK1. Abz-Lys-Phe-Phe-Pro-Arg-Gln-EDDnp, Abz-Lys-Phe-Arg-Pro-Arg-Gln-EDDnp and acetyl-Lys-Phe-Phe-Pro-Leu-Glu-NH2 inhibited hK1 in the range 20-30 nM (letters in italics denote the D-form of the amino acid). the peptide acetyl-Lys-Phe-Phe-Pro-Leu-Glu-NH2 was a weak inhibitor for other serine proteases, as indicated by the higher K-i values compared with hK1, but this peptide was a potent inhibitor of human plasma kallikrein, which has a Ki value of 8 nM. This result was surprising, since this enzyme is known to be a restricted arginyl-hydrolase. in conclusion, acetyl-Lys-Phe-Phe-Pro-Leu-Glu-NH2 can be used as a leader compound to design specific inhibitors for hK1, plasma kallikrein, or for both at same time, if the inhibition of kinin release is the main goal.Universidade Federal de São Paulo, Escola Paulista Med, Dept Biophys, BR-04044020 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Biophys, BR-04044020 São Paulo, BrazilWeb of Scienc

Metabolic syndrome, dyslipidemia, hypertension and type 2 diabetes in youth: from diagnosis to treatment

Overweight and obesity in youth is a worldwide public health problem. Overweight and obesity in childhood and adolescents have a substantial effect upon many systems, resulting in clinical conditions such as metabolic syndrome, early atherosclerosis, dyslipidemia, hypertension and type 2 diabetes (T2D). Obesity and the type of body fat distribution are still the core aspects of insulin resistance and seem to be the physiopathologic links common to metabolic syndrome, cardiovascular disease and T2D. The earlier the appearance of the clustering of risk factors and the higher the time of exposure, the greater will be the chance of developing coronary disease with a more severe endpoint. The age when the event may occur seems to be related to the presence and aggregation of risk factors throughout life

Fabrication of low electrical percolation threshold multi-walled carbon nanotube sensors using magnetic patterning

Soft robotics is an expanding area with multiple applications; however, building low-cost, soft, and flexible robots requires the development of sensors that can be directly integrated into the soft robotics fabrication process. Thus, the motivation for this work was the design of a low-cost fabrication process of flexible sensors that can detect touch and deformation. The fabrication process proposed uses a flexible polymer nanocomposite with permanent magnets strategically placed where the conductive electrodes should be. The nanocomposite is based on poly(dimethylsiloxane) (PDMS) and multi-walled carbon nanotubes (MWCNTs). The MWCNT contains ferromagnetic impurities remaining from the synthesis process, which can be used for magnetic manipulation. Several electrode geometries were successfully simulated and tested. The magnetic patterning was simulated, allowing the fabrication of conductive patterns within the composite. This fabrication process allowed the reduction of the electrical resistivity of the nanocomposites as compared to the composites with homogeneous MWCNT dispersion. It also allowed the fabrication of piezoresistive and triboelectric sensors at MWCNT concentration as low as 0.5 wt.%. The fabrication process proposed is flexible, allows the development of sensors for soft robotics, as well as monitoring large and unconventional areas, and may be adapted to different mould shapes and polymers at low cost.This research is part of the PhD project at the Doctoral Program in Advanced Materials and Processing—FEUP. We would like to thank CeNTI for providing resources (labs, equipment and consumables) to perform the fabrication and characterisation of the samples. The authors thank CEMUP for expert assistance (Rui Rocha) with SEM-EDS. IPC acknowledges the support of FCT through National Funds References UIDB/05256/2020 and UIDP/05256/2020

A dental pre-screening system: usability and user perception

Background: Accessing dental treatment is still a challenge in several countries. In Brazil, there is a deficit in the provision of dental services by the public health system, with an emphasis on specialised treatments. The poorest are most affected and usually have to travel long distances for treatment in other regions, with the associated costs of travel, food, and often the loss of a day's work. Aiming to improve care for this public, the Dental Pre-Screening System (in Portuguese, Sistema de Pré-Triagem Odontológica - STO) was developed, which is responsive (mobile) and aims at remotely pre-screening these patients by an oral health professional. Objective: This pilot study was developed to analyse the system's usability by developers and patients and the subjects' perceptions during the use of the STO through semi-structured interviews. Methods: A convenience sample (35 patients and 10 developers) with a mixed methodology was used to evaluate usability (System Usability Scale) and to measure the user's perception (semi-structured interview) of the components of the Dental Pre-Screening System. Results: The system's overall System Usability Scale (SUS) score was 76.9. Among the patients, Twenty-four patients found the system easy to use, 83% agreed or completely agreed that they would like to use this system frequently" and 83% agreed or strongly agreed that people would learn to use it quickly. Qualitative data suggest that all of the patients would recommend using the system, and the patients' perception of the system was positive and optimistic. However, it is also possible to identify points to be improved, such as changing the calendar format. Conclusions: The results of the SUS and semi-structured interview showed that the Dental Pre-Screening System was well accepted and that it can optimise the face-to-face screening process, reducing unnecessary trips and saving money.     &nbsp

Perspectivas no isolamento de microRNA de punção aspirativa por agulha fina de tiroide: resposta à carta Ácidos nucleicos extraídos de lâminas com citologia de punção de agulha fina de tiroide

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Laboratory of Molecular and Translational EndocrinologyUNIFESP-EPM Laboratory of Molecular and Translational EndocrinologyUNIFESP, EPM, Laboratory of Molecular and Translational EndocrinologyUNIFESP, EPM Laboratory of Molecular and Translational EndocrinologySciEL

Recent progress and novel perspectives on obesity pharmacotherapy

O aumento da prevalência da obesidade, nas últimas décadas, é alarmante, o que implica um grande número de pacientes sob risco de complicações metabólicas e cardiovasculares associadas. A eficácia modesta a longo prazo das modificações de estilo de vida isoladamente exige a necessidade de intervenções mais agressivas, seja por meio do uso adjuvante de medicamentos ou da abordagem mais radical cirúrgica. A cirurgia bariátrica, embora até hoje tenha se mostrado o método mais efetivo de tratamento dessa enfermidade, pode estar associada a complicações nutricionais e metabólicas ainda não totalmente esclarecidas. Contrasta com esse fato a disponibilidade limitada de agentes antiobesidade atualmente no mercado, além de fatos históricos que envolveram a suspensão de alguns fármacos previamente existentes, por questões de segurança. Este artigo tem como objetivo apresentar dados recentes de estudos clínicos de novas drogas propostas para o tratamento da obesidade com perspectivas breves de serem lançadas no mercado, caso passem pela aprovação das agências regulatórias. Nesta revisão serão discutidas a eficácia e a segurança desses fármacos, que incluem a lorcaserina (agonista serotoninérgico seletivo 5-HT2c), tesofensina (inibidor triplo de recaptação de monoaminas), liraglutide (análogo do GLP-1) e cetilistate (inibidor de lipases gastrointestinais), além das combinações de bupropiona/naltrexona, bupropiona/zonisamida, fentermina/topiramato e pramlintide/metreleptina.Obesity prevalence has risen dramatically over the past decades, which poses a great number of patients at risk of metabolic and cardiovascular complications. Long-term efficacy of lifestyle modification isolated has shown to be modest which, therefore, urges the need of more aggressive interventions such as adjuvant pharmacotherapy or the more radical surgical approach. Bariatric surgery has proven to date to be the most effective treatment, although it may be associated with nutritional and metabolic complications not yet completely recognized. By contrast, there is limited availability of antiobesity agents currently in the market, as well as historical facts involving the suspension of previously existing medications due to safety concerns. This article aims to present recent data on clinical trials of novel weight-loss drugs with short perspective to enter the market, if approved by the regulatory agencies. This review will discuss the efficacy and safety of these compounds, which include lorcaserin (selective serotonin 5-HT2c agonist), tesofensine (triple monoamine reuptake inhibitor), liraglutide (GLP-1 analogue) and cetilistat (gastrointestinal lipase inhibitor), as well as the combination therapies of bupropion/naltrexone, bupropion/zonisamide, phentermine/topiramate and pramlintide/metreleptin