361 research outputs found
Bending the Arc Toward Justice: The Current Era of Juvenile Justice Reform in Georgia
America’s juvenile justice system is experiencing another era of reform. The formal juvenile justice system originated from the ideology and methods of social reformers who viewed deviant behavior as a treatable condition and sought redemption of criminal youth. In the first era of reform, that view powered the state’s exercise of its parens patriae authority and produced a paternalistic judiciary and institutions that used custody as a means of achieving social control. Over time, changing political and social views of childhood and a growing recognition in the law of children as rights-holders shifted the system’s focus away from the rehabilitative ideal. At its extreme, this second era of reform abandoned the developmental view of youth crime in favor of a public safety orientation and resulted in a system overcorrection. The present era of juvenile justice system reform preserves the developmental approach and restores the rehabilitative ideal while striking a better balance between state interests and the rights of individual children.
This Article traces the history of the juvenile justice system and reflects on the present era of system reform. Early indications suggest that, through the use of evidence previously not available, the current era of juvenile justice system reform has the potential to restore the rehabilitative ideal on which the system was founded without compromising public safety goals or the legal rights of system-involved children. This Article specifically documents the effort, engagement, and leadership across public and private sectors to effectuate such balanced state-level reform in Georgia—the focus of this Symposium
FUN3D and USM3D Analysis of the Propulsion Aerodynamic Workshop 2018 S-Duct Test Case
This work presents the results of Fun3D and USM3D analyses that were performed for the 4th AIAA Propulsion Aerodynamics Workshop (PAW). The PAW workshop is separated into three sections that focus on internal duct flows, nozzle flows and a special topic. This paper focuses on the internal duct flow section of PAW04 while an accompanying paper discusses the analyses performed for the nozzle portion. For the internal duct flow section, the PAW04 participants were provided with the two configurations consisting of an S-duct with and without aerodynamic interface plane (AIP) rake legs modeled. The participants were asked to perform a grid refinement study as well as a turbulence model study for the configuration with the rake legs. The analyses discussed here were performed on custom grids developed under the guidelines of the workshop. Additionally, the paper discusses the development and use of flow controllers for matching the desired flow characteristics. The results show that both solvers do well for predicting internal flow characteristics of the S-duct based on direct comparison with the experimental data. However, the CFD-to-CFD comparison proved to be more challenging due to the localized occurrence of supersonic flow near the rake legs when using the mass flow controller. A turbulence model study was performed to compare the two-equation SST model to the SA-QCR model. The results show that although the turbulence model does affect the solution, it makes a minimal impact on pressure recovery and inlet distortion intensity for this case. Suggestions for future workshops include gridding guidelines similar to those employed for the Drag Prediction Workshop series for the grid refinement study and a time accuracy study
Blended-Wing-Body Transonic Aerodynamics: Summary of Ground Tests and Sample Results
The Blended-Wing-Body (BWB) concept has shown substantial performance benefits over conventional aircraft configuration with part of the benefit being derived from the absence of a conventional empennage arrangement. The configuration instead relies upon a bank of trailing edge devices to provide control authority and augment stability. To determine the aerodynamic characteristics of the aircraft, several wind tunnel tests were conducted with a 2% model of Boeing's BWB-450-1L configuration. The tests were conducted in the NASA Langley Research Center's National Transonic Facility and the Arnold Engineering Development Center s 16-Foot Transonic Tunnel. Characteristics of the configuration and the effectiveness of the elevons, drag rudders and winglet rudders were measured at various angles of attack, yaw angles, and Mach numbers (subsonic to transonic speeds). The data from these tests will be used to develop a high fidelity simulation model for flight dynamics analysis and also serve as a reference for CFD comparisons. This paper provides an overview of the wind tunnel tests and examines the effects of Reynolds number, Mach number, pitch-pause versus continuous sweep data acquisition and compares the data from the two wind tunnels
FUN3D and USM3D Analysis of the 4th AIAA Propulsion Aerodynamics Workshop Nozzle Test Case
This work presents the results of FUN3D and USM3D analyses that were performed for the 4th AIAA Propulsion Aerodynamics Workshop. The workshop was separated into three sections that focus on internal duct flows, nozzle flows, and a special topic of interest. This paper focuses on the nozzle section while an accompanying paper discusses the analyses performed for the internal duct flow section. For the nozzle flow section, the participants were provided with two configurations consisting of a rectangular convergent nozzle with and without an aft-deck. User-generated grids were developed under the guidelines of the workshop for the present analyses. The results show that both solvers compare favorably to the experimental results for the baseline nozzle with the largest differences observed at the lower NPR values. Additionally, both solvers showed favorable agreement with the experimental data for the pressures on the surface of the aft-deck. However, neither solver was able to match the jet flow further downstream for the nozzle with aft-deck configuration. A turbulence model study was conducted to compare the two-equation SST model, SA-QCR model, and two-equation k-kL model (FUN3D only). The results show that the SA-QCR turbulence model was unable to match the experimental results downstream of the nozzle. The k-kL model was shown to better match the experimental data compared to the SST model for most cases simulated using the FUN3D flow solver. Suggestions for future workshops include gridding guidelines similar ion Workshop series for the grid refinement study and a reduction in scope to allow for more detailed exploration of the individual problems.
rticipation by reducing time requirement
Preliminary evidence of increased striatal dopamine in a nonhuman primate model of maternal immune activation.
Women exposed to a variety of viral and bacterial infections during pregnancy have an increased risk of giving birth to a child with autism, schizophrenia or other neurodevelopmental disorders. Preclinical maternal immune activation (MIA) models are powerful translational tools to investigate mechanisms underlying epidemiological links between infection during pregnancy and offspring neurodevelopmental disorders. Our previous studies documenting the emergence of aberrant behavior in rhesus monkey offspring born to MIA-treated dams extends the rodent MIA model into a species more closely related to humans. Here we present novel neuroimaging data from these animals to further explore the translational potential of the nonhuman primate MIA model. Nine male MIA-treated offspring and 4 controls from our original cohort underwent in vivo positron emission tomography (PET) scanning at approximately 3.5-years of age using [18F] fluoro-l-m-tyrosine (FMT) to measure presynaptic dopamine levels in the striatum, which are consistently elevated in individuals with schizophrenia. Analysis of [18F]FMT signal in the striatum of these nonhuman primates showed that MIA animals had significantly higher [18F]FMT index of influx compared to control animals. In spite of the modest sample size, this group difference reflects a large effect size (Cohen's d = 0.998). Nonhuman primates born to MIA-treated dams exhibited increased striatal dopamine in late adolescence-a hallmark molecular biomarker of schizophrenia. These results validate the MIA model in a species more closely related to humans and open up new avenues for understanding the neurodevelopmental biology of schizophrenia and other neurodevelopmental disorders associated with prenatal immune challenge
Low-speed Aerodynamic Investigations of a Hybrid Wing Body Configuration
Two low-speed static wind tunnel tests and a water tunnel static and dynamic forced-motion test have been conducted on a hybrid wing-body (HWB) twinjet configuration. These tests, in addition to computational fluid dynamics (CFD) analysis, have provided a comprehensive dataset of the low-speed aerodynamic characteristics of this nonproprietary configuration. In addition to force and moment measurements, the tests included surface pressures, flow visualization, and off-body particle image velocimetry measurements. This paper will summarize the results of these tests and highlight the data that is available for code comparison or additional analysis
Experimental Investigation of the Low-Speed Aerodynamic Characteristics of a 5.8-Percent Scale Hybrid Wing Body Configuration
A low-speed experimental investigation has been conducted on a 5.8-percent scale Hybrid Wing Body configuration in the NASA Langley 14- by 22-Foot Subsonic Tunnel. This Hybrid Wing Body (HWB) configuration was designed with specific intention to support the NASA Environmentally Responsible Aviation (ERA) Project goals of reduced noise, emissions, and fuel burn. This HWB configuration incorporates twin, podded nacelles mounted on the vehicle upper surface between twin vertical tails. Low-speed aerodynamic characteristics were assessed through the acquisition of force and moment, surface pressure, and flow visualization data. Longitudinal and lateral-directional characteristics were investigated on this multi-component model. The effects of a drooped leading edge, longitudinal flow-through nacelle location, vertical tail shape and position, elevon deflection, and rudder deflection have been studied. The basic configuration aerodynamics, as well as the effects of these configuration variations, are presented in this paper
Uptake of Direct Acting Antivirals for Hepatitis C Virus in a New England Medicaid Population, 2014-2017
Introduction
Introduction of the direct acting antiviral (DAA) sofosbuvir (SOV) in 2013 offered significant improvement over previous options for hepatitis C virus (HCV) treatment. Initial uptake was low in Medicaid and other populations, perhaps in part due to high drug cost and prior authorization (PA) restrictions related to fibrosis stage, prescribing provider specialty, and sobriety. Both the subsequent introduction of ledipasvir/sofosbuvir (LDV/SOV), an all-oral regimen for most genotypes, and lifting of PA restrictions were expected to increase overall uptake, but little is known about recent prescribing patterns. We examined trends in DAA uptake in a Medicaid population and identified the effect of these two events on treatment initiation.
Study Design
An interrupted time series (ITS) design utilized enrollment, medical, and pharmacy claims from Medicaid enrollees in three New England states, 12/2013-12/2017. Trends in treatment uptake, defined as 1+ pharmacy claim for a DAA, were examined overall, by demographic characteristics, and prior to and after two time points: 10/2014 (LDV/SOV approval date) and 7/2016 (date PA restrictions affecting two-thirds of members were lifted). Chi-square evaluated demographic differences, segmented regression models examined trends.
Study Population
The population included members ages 18-64 years with HCV (2+ claims with ICD-9/10 code for HCV or 1+ claim for chronic HCV). Eligible individuals remained in the sample until treatment initiation or Medicaid disenrollment.
Findings
The analytic sample averaged 30,433 members with HCV per month, mean age 42.9 years, 60% male. In 2014 3.3% of eligible members initiated treatment, increasing to 7.7% in 2017 (p =
Conclusion
While initial uptake of DAAs was low in this multi-state Medicaid population, treatment initiation among eligible members increased through 2017. Introduction of new medications and lifting of PA restrictions led to an immediate increase in uptake followed by relatively flat monthly utilization.
Policy implications
Sharp increases in uptake after LDV/SOV introduction may indicate warehousing of members in anticipation of LDV/SOV approval; increases after PA restrictions were lifted indicates demand for treatment among those affected by restrictions. As a large percentage of the Medicaid HCV population remains untreated, planned provider interviews will help to understand barriers and facilitators of treatment for HCV
Satellite detection of dinoflagellate blooms off California by UV reflectance ratios
© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Kahru, M., Anderson, C., Barton, A. D., Carter, M. L., Catlett, D., Send, U., Sosik, H. M., Weiss, E. L., & Mitchell, B. G. Satellite detection of dinoflagellate blooms off California by UV reflectance ratios. Elementa: Science of the Anthropocene, 9(1), (2021): 00157, https://doi.org/10.1525/elementa.2020.00157.As harmful algae blooms are increasing in frequency and magnitude, one goal of a new generation of higher spectral resolution satellite missions is to improve the potential of satellite optical data to monitor these events. A satellite-based algorithm proposed over two decades ago was used for the first time to monitor the extent and temporal evolution of a massive bloom of the dinoflagellate Lingulodinium polyedra off Southern California during April and May 2020. The algorithm uses ultraviolet (UV) data that have only recently become available from the single ocean color sensor on the Japanese GCOM-C satellite. Dinoflagellates contain high concentrations of mycosporine-like amino acids and release colored dissolved organic matter, both of which absorb strongly in the UV part of the spectrum. Ratios 1, consistent with historical observations showing a sharp transition from dinoflagellate- to diatom-dominated waters in these areas. UV bands are thus potentially useful in the remote sensing of phytoplankton blooms but are currently available only from a single ocean color sensor. As several new satellites such as the NASA Plankton, Aerosol, Cloud, and marine Ecosystem mission will include UV bands, new algorithms using these bands are needed to enable better monitoring of blooms, especially potentially harmful algal blooms, across large spatiotemporal scales.Part of this work was funded by National Science Foundation (NSF) grants to the CCE-LTER Program, most recently OCE-1637632. Processing of Second-Generation Global Imager satellite data was funded by Japan Aerospace Exploration Agency. Data shown in Figure 1 were collected by BGM and MK with support from the NASA SIMBIOS project. DC was supported by the NASA Biodiversity and Ecological Forecasting Program (Grant NNX14AR62A), the Bureau of Ocean and Energy Management Ecosystem Studies Program (BOEM award MC15AC00006), and the NOAA through the Santa Barbara Channel Marine Biodiversity Observation Network. HMS was supported by NSF (Grant OCE-1810927) and the Simons Foundation (Grant 561126). ELW was supported by NSF GRFP (Grant DGE-1650112). Funding for Scripps and Santa Monica Piers sampling was through the Southern California Coastal Ocean Observing Harmful Algal Bloom Monitoring Program by NOAA NA16NOS0120022
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