Uberon: towards a comprehensive multi-species anatomy ontology

The lack of a single unified species-neutral ontology covering the anatomy of a variety of metazoans is a hindrance to translating model organism research to human health. We have developed an Uber-anatomy ontology to fill this need, filling the gap between the CARO upper-level ontology and species-specific anatomical ontologies

College Ready at a Cost: Underrepresented Students Overwhelmed, Scared, Increasingly Stressed, and Coping

As the push and expectation to attend college continues to increase, making the process of getting into college more competitive than ever before, there is a need to interrogate whether and how efforts to create a college-going culture and increase college readiness among students, particularly those from historically marginalized backgrounds, might have an adverse impact on students. This study illuminates 59 students’ voices who participated in a multisite descriptive case study examining the strong college-going culture and college readiness efforts at three racially and economically diverse urban public high schools in different regions of Texas. Although students revealed positive aspects of their schools’ efforts, this study focuses on some of the negative, unintended consequences related to how students felt and coped with being overwhelmed, scared, and increasingly stressed as a result of the narrow focus on college readiness. Such findings must be considered by scholars, policymakers, and practitioners alike

Do impulsivity and biological sex moderate associations between alcohol-related sexual willingness and behavior among young adults?

This study examined three-way interactions between baseline levels of willingness to engage in alcohol-related sexual behaviors, facets of impulsivity (i.e., urgency, lack of premeditation, and sensation seeking) and biological sex on alcohol-related sexual behaviors 6 months later. Participants were a sample of high-risk 18–25 year olds (N = 321, mean age 22.44) from a larger randomized controlled trial with eligibility criteria including engaging in unprotected sexual behavior after drinking alcohol within the past month at baseline. Results indicated females reporting high urgency and willingness levels were the most likely to engage in alcohol-related sex and to use a condom/dental dam after drinking. Males reporting low urgency levels and high sensation seeking and willingness levels engaged in more alcohol-related sex compared to females. Interventions to decrease alcohol-related sexual behavior by reducing willingness could incorporate sex-specific and impulsivity-related content, particularly related to urgency

Use of Continuous Renal Replacement Therapy for Removal of Dabigatran in a Patient in Need of Emergent Surgery

Purpose. To report the ability to remove serum dabigatran using continuous renal replacement therapy (CRRT) in a patient with life-threatening bleeding. Summary. A 77-year-old female with history of atrial fibrillation who takes dabigatran for stroke prevention presented with abdominal pain. Patient was found to have bleeding and possible mesenteric ischemia and was taken to the operating room and had continued bleeding postoperatively. CRRT was initiated for the removal of any remaining dabigatran, with serum dabigatran levels collected to evaluate removal of dabigatran with CRRT. This patient had an increased dabigatran level prior to intervention, which decreased to an undetectable level after use of CRRT. Greater than 80% of the drug was removed due to 4 hours of CRRT and residual kidney function. Reversal of dabigatran is an area of current research with recent FDA approval of idarucizumab for use. Conclusion. Bleeding may occur as a result of the use of dabigatran and change in patient’s clinical condition. Use of CRRT may be an option in removing serum dabigatran in the case of a life-threatening bleed

Use of Continuous Renal Replacement Therapy for Removal of Dabigatran in a Patient in Need of Emergent Surgery

Purpose. To report the ability to remove serum dabigatran using continuous renal replacement therapy (CRRT) in a patient with life-threatening bleeding. Summary. A 77-year-old female with history of atrial fibrillation who takes dabigatran for stroke prevention presented with abdominal pain. Patient was found to have bleeding and possible mesenteric ischemia and was taken to the operating room and had continued bleeding postoperatively. CRRT was initiated for the removal of any remaining dabigatran, with serum dabigatran levels collected to evaluate removal of dabigatran with CRRT. This patient had an increased dabigatran level prior to intervention, which decreased to an undetectable level after use of CRRT. Greater than 80% of the drug was removed due to 4 hours of CRRT and residual kidney function. Reversal of dabigatran is an area of current research with recent FDA approval of idarucizumab for use. Conclusion. Bleeding may occur as a result of the use of dabigatran and change in patient’s clinical condition. Use of CRRT may be an option in removing serum dabigatran in the case of a life-threatening bleed

Off-Design Reynolds Number Effects for a Supersonic Transport

A high Reynolds number wind tunnel test was conducted to assess Reynolds number effects on the aerodynamic performance characteristics of a realistic, second-generation supersonic transport concept. The tests included longitudinal studies at transonic and low-speed, high-lift conditions across a range of chord Reynolds numbers (8 million to 120 million). Results presented focus on Reynolds number and static aeroelastic sensitivities at Mach 0.30 and 0.90 for a configuration without a tail. Static aeroelastic effects, which mask Reynolds number effects, were observed. Reynolds number effects were generally small and the drag data followed established trends of skin friction as a function of Reynolds number. A more nose-down pitching moment was produced as Reynolds number increased because of an outward movement of the inboard leading-edge separation at constant angles of attack. This study extends the existing Reynolds number database for supersonic transports operating at off-design conditions

Investigations for Supersonic Transports at Transonic and Supersonic Conditions

Several computational studies were conducted as part of NASA s High Speed Research Program. Results of turbulence model comparisons from two studies on supersonic transport configurations performed during the NASA High-Speed Research program are given. The effects of grid topology and the representation of the actual wind tunnel model geometry are also investigated. Results are presented for both transonic conditions at Mach 0.90 and supersonic conditions at Mach 2.48. A feature of these two studies was the availability of higher Reynolds number wind tunnel data with which to compare the computational results. The transonic wind tunnel data was obtained in the National Transonic Facility at NASA Langley, and the supersonic data was obtained in the Boeing Polysonic Wind Tunnel. The computational data was acquired using a state of the art Navier-Stokes flow solver with a wide range of turbulence models implemented. The results show that the computed forces compare reasonably well with the experimental data, with the Baldwin-Lomax with Degani-Schiff modifications and the Baldwin-Barth models showing the best agreement for the transonic conditions and the Spalart-Allmaras model showing the best agreement for the supersonic conditions. The transonic results were more sensitive to the choice of turbulence model than were the supersonic results

A Prospective Study of Predictors and Consequences of Hooking Up for Sexual Minority Women

Hooking up, which refers to a sexual encounter (ranging from kissing to penetrative sex) between individuals who are not in a committed relationship, is an increasingly normative form of sexual exploration among emerging adults. Past research has focused on hookups within a heteronormative context, and some of this work has examined hookups as a way to cope with distress. Building on this work, we examined the role of hookups as a means for lesbian and bisexual women to cope with minority stress through increasing connection and engagement with the LGBTQ (lesbian/gay/bisexual/transgender/queer or questioning) community. A nationally recruited sample of 520 lesbian and bisexual women ages 18 to 25 completed questionnaires regarding their hookup behaviors as part of a longitudinal study. Childhood sexual abuse, posttraumatic stress symptoms, alcohol use, minority stress, and involvement and connectedness with the LGBTQ community were also assessed. First, regression analyses were used to examine baseline predictors of hookup behaviors reported at a 12-month follow-up. Findings revealed that alcohol use was associated with a greater likelihood of any subsequent hookups, and individuals reporting more minority stress subsequently hooked up with more partners. Second, hookup behaviors at 12 months were examined as predictors of outcomes at a 24-month follow-up, after controlling for baseline variables. Findings revealed that hookup behaviors were associated with reduced minority stress as well as increased involvement with and connectedness to the LGBTQ community, suggesting hookups may serve a protective function. Overall, findings support the notion that for sexual minority women, hookups may operate as a means of coping and connection