An optimization model for metabolic pathways

This article is available open access through the publisher’s website through the link below. Copyright @ The Author 2009.Motivation: Different mathematical methods have emerged in the post-genomic era to determine metabolic pathways. These methods can be divided into stoichiometric methods and path finding methods. In this paper we detail a novel optimization model, based upon integer linear programming, to determine metabolic pathways. Our model links reaction stoichiometry with path finding in a single approach. We test the ability of our model to determine 40 annotated Escherichia coli metabolic pathways. We show that our model is able to determine 36 of these 40 pathways in a computationally effective manner. Contact: [email protected] Supplementary information: Supplementary data are available at Bioinformatics online (http://bioinformatics.oxfordjournals.org/cgi/content/full/btp441/DC1)

Cañete y sus alrededores (provincia de Cuenca): un ejemplo de vínculo entre la historia geológica y la humana-cultural

Se considera que la historia geológica de una zona determinada esta condicionando de manera importante la forma de vida de sus gentes, costumbres, etc., por ello vemos también la importancia de que aquélla sea de algún modo conocida . Se presenta en el trabajo la historia geológica como la primera parte y más larga de lo que sería una "historia general" que terminar1a con una parte más reciente o humana - cultural, con la cual, pues, habría un "encadenamiento". Se considera el papel importante del geólogo y algunos organismos oficiales en la difusión de algunas ideas elementales sobre la geologla más próxima de los alrededores en los distintos medios rurales. El presente trabajo muestra un ejemplo de "encadenamiento histórico" en la zona de Canete y sus alrededores (provincia de Cuenca)

Isoenzimas de láctico-deshidrogenasa : regulación metabolíca

Le 11 janvier 1966, Alberto Giacometti décède à l’hôpital de Coire. Trois ans plus tard paraît chez l’éditeur Tériade Paris sans fin, composé d’un texte de l’artiste intercalé dans une séquence de 149 lithographies, précédées d’un frontispice emblématique. Les visions narcissiques de la ville croquées par Giacometti entretiennent des relations complexes avec la photographie et le cinéma contemporains, à un moment de sa vie où la morbidité l’angoisse. Au même moment, au fil de divers entretiens, Giacometti dévoile son rêve : dominer sa vision et fixer un réel qui lui échappe

Phylloceratina ammonoids in the Iberian Basin during the Middle Jurassic: a model of biogeographical and taphonomic dispersal related to relative sea-level changes

Phylloceratina and Lytoceratina ammonoids in the Middle Jurassic of the Iberian Chain (E. Spain) represent less than 1% of the whole of Ammonoidea. There are two intervals, however, in which their occurrence is remarkably constant: within the Upper Bajocian and at the Lower/Middle Callovian boundary. These two dispersal episodes of Phylloceratina and Lytoceratina into the Iberian Basin are regarded to reflect changes in their palaeoecological and taphonomical behaviour, as a consequence of regional sea-level changes during the Middle Jurassic. A relative rise during the Late Bajocian favoured the immigration of juvenile phyllocerataceans. Phylloceras and Adabofoloceras immigrations gave rise to monospecific assemblages, where they soon died. They did not breed or ontogenically develop in this basin. In contrast, phyllocerataceans recorded at the Lower/Middle Callovian boundary constitute polyspecific assemblages, dominated by adult individuals. These Callovian assemblages were formed by nekroplanktonic drift, related to a relative sea-level fall and general homogenization of the shelf bottom, hence favouring the concentration of remains of organisms from more open marine and oceanic areas

Taphonomic features of ammonite associations developed in deep carbonate platform environments (Oxfordian, Iberian Range, Spain).

Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasTRUEpu

Isoenzimas de láctico-deshidrogenasa : regulación metabolíca

Tsis inédita leída en la Universidad de Madrid, Facultad de Ciencias, Sección de Biológicas, 1972Universidad de MadridTRUEProQuestpu