Autoestímate

Programa de intervención.En este Trabajo Fin de Grado se presenta un programa de intervención destinado al segundo ciclo de Educación Infantil, en concreto niños y niñas de 4 a 5 años, basado en la autoestima, las emociones, las relaciones con los iguales y el desarrollo personal. Está diseñado para ser implementado en el ámbito escolar. Este programa se divide en dos bloques de contenidos relacionados con la temática de la autoestima. El primer bloque se inicia con el conocimiento por parte del alumnado del concepto de autoestima, para posteriormente desarrollar un conocimiento de sí mismo, y también, de sus emociones. El segundo bloque trabaja las relaciones con los iguales y la participación de la familia en la construcción de la autoestima del alumnado, pues ambos juegan un papel determinante. El objetivo que se pretende conseguir con este programa de intervención es la mejora de la autoestima del alumnado, en los diferentes aspectos de su vida cotidiana, como el entorno familiar y el de los iguales. Se realizará una evaluación final con una serie de ítems para comprobar el aprendizaje del alumnado después de realizar dicho programa.Universidad de Granada. Facultad de Ciencias de la Educación. Grado en Educación Infanti

Eficacia de una intervención en psicología positiva combinada con terapia cognitivo conductual en estudiantes universitarios

The aim of this study was to design and implement a positive intervention combined with cognitive-behavioral therapy to enhance subjective and psychological well-being and other positive functioning constructs in a convenience sample. Participants analysed were 48 university students (mean age 22.25),25 assigned nonrandomized to intervention condition and 23 to no-treatment waiting-list control condition. All participants were assessed pre- and post-intervention to test the treatment program effectiveness. Repeated-measures ANCOVAs, controlling baseline differences between the two groups, indicated that the intervention group reported greater social support after the intervention period than the waiting-list control group. Within-group differences were found for happiness, self-acceptance, positive relations with others, optimism, and self-esteem in the intervention group; these differences did not appear in the waiting-list control group. These findings suggest the limited capacity of this intervention program for improving well-being through positive activities combined with cognitive-behavioral therapy. Future research should analyse what kind of activities could be more effective in promoting well-beingdepending on the characteristics of participants.El objetivo de este estudio fue diseñar e implementar una intervención positiva combinada con técnicas de terapia cognitiva-conductual para mejorar el bienestar subjetivo y psicológico, así como otras variables de funcionamiento positivo en una muestra de conveniencia. Los participantes analizados fueron 48 estudiantes universitarios (media 22.25 años). Se llevó a cabo una asignación no aleatorizada de los participantes a la condición de intervención (n = 25) y  a la condición de control en lista de espera sin tratamiento (n = 23). Todos los participantes fueron evaluados antes y después de la intervención para probar la efectividad del programa de tratamiento. Los ANCOVAs de medidas repetidas, controlando las diferencias de la línea base entre los dos grupos, indicaron que el grupo de intervención mostraba mayor apoyo social después del período de intervención que en el grupo control en lista de espera. Se encontraron diferencias intragrupo en felicidad, auto-aceptación, relaciones positivas con los otros, optimismo y autoestima para el grupo de intervención, mientras que estas diferencias no aparecían en el grupo de control en lista de espera. Estos hallazgos sugieren la capacidad limitada de este programa de intervención para mejorar el bienestar a través de actividades positivas combinado con terapia cognitivo-conductual. Las investigaciones futuras deberían analizar qué tipo de actividades podrían ser más eficaces en la promoción del bienestar en función de las características de los participantes

Modelling soil organic carbon stocks in global change scenarios: a CarboSOIL application

Global climate change, as a consequence of the increasing levels of atmospheric CO2 concentration, may significantly affect both soil organic C storage and soil capacity for C sequestration. CarboSOIL is an empirical model based on regression techniques and developed as a geographical information system tool to predict soil organic carbon (SOC) contents at different depths. This model is a new component of the agro-ecological decision support system for land evaluation MicroLEIS, which assists decision-makers in facing specific agro-ecological problems, particularly in Mediterranean regions. In this study, the CarboSOIL model was used to study the effects of climate change on SOC dynamics in a Mediterranean region (Andalusia, S Spain). Different downscaled climate models were applied based on BCCR-BCM2, CNRMCM3, and ECHAM5 and driven by SRES scenarios (A1B, A2 and B2). Output data were linked to spatial data sets (soil and land use) to quantify SOC stocks. The CarboSOIL model has proved its ability to predict the short-medium- and long-term trends (2040s, 2070s and 2100s) of SOC dynamics and sequestration under projected future scenarios of climate change. Results have shown an overall trend towards decreasing of SOC stocks in the upper soil sections (0–25 cm and 25–50 cm) for most soil types and land uses, but predicted SOC stocks tend to increase in the deeper soil section (0–75 cm). Soil types as Arenosols, Planosols and Solonchaks and land uses as “permanent crops” and “open spaces with little or no vegetation” would be severely affected by climate change with large decreases of SOC stocks, in particular under the medium–high emission scenario A2 by 2100. The information developed in this study might support decision-making in land management and climate adaptation strategies in Mediterranean regions, and the methodology could be applied to other Mediterranean areas with available soil, land use and climate data.Ministerio de Economía y CompetitividadJunta de Andalucí

The ecology and evolution of the monito del monte, a relict species from the southern South America temperate forests

The arboreal marsupial monito del monte (genus Dromiciops, with two recognized species) is a paradigmatic mammal. It is the sole living representative of the order Microbiotheria, the ancestor lineage of Australian marsupials. Also, this marsupial is the unique frugivorous mammal in the temperate rainforest, being the main seed disperser of several endemic plants of this ecosystem, thus acting as keystone species. Dromiciops is also one of the few hibernating mammals in South America, spending half of the year in a physiological dormancy where metabolism is reduced to 10% of normal levels. This capacity to reduce energy expenditure in winter contrasts with the enormous energy turnover rate they experience in spring and summer. The unique life history strategies of this living Microbiotheria, characterized by an alternation of life in the slow and fast lanes, putatively represent ancestral traits that permitted these cold-adapted mammals to survive in this environment. Here, we describe the ecological role of this emblematic marsupial, summarizing the ecophysiology of hibernation and sociality, updated phylogeographic relationships, reproductive cycle, trophic relationships, mutualisms, conservation, and threats. This marsupial shows high densities, despite presenting slow reproductive rates, a paradox explained by the unique characteristics of its three-dimensional habitat. We finally suggest immediate actions to protect these species that may be threatened in the near future due to habitat destruction and climate change.Fil: Fontúrbel, Francisco E.. Pontificia Universidad Católica de Valparaíso; ChileFil: Franco, Lida M.. Universidad de Ibagué; ColombiaFil: Bozinovic, Francisco. Pontificia Universidad Católica de Chile; ChileFil: Quintero Galvis, Julian F.. Universidad Austral de Chile; ChileFil: Mejías, Carlos. Universidad Austral de Chile; ChileFil: Amico, Guillermo Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; ArgentinaFil: Vazquez, Miriam Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; ArgentinaFil: Sabat, Pablo. Universidad de Chile; ChileFil: Sánchez Hernández, Juan C.. Universidad de Castilla-La Mancha; EspañaFil: Watson, David M.. Charles Sturt University; AustraliaFil: Saenz Agudelo, Pablo. Universidad Austral de Chile; ChileFil: Nespolo, Roberto F.. Universidad Austral de Chile; Chil

Visceral adipose tissue triggers tau pathogenesis in transgenic mice

Alzheimer’s disease (AD) is a complex disorder and multiple cellular and molecular mechanisms are involved in AD onset and progression. Recent evidences have suggested that metabolic alterations are an important pathological feature in disease progression in AD. Likewise, diabetes and obesity, two mayor metabolic illnesses, are risk factors for AD. These two overwhelming diseases are associated with a significant expansion of visceral adipose tissue. Here, we hypothesize that the visceral adipose tissue may serve as a key communicator organ between the brain and peripheral metabolic illnesses and affecting both types of disorders. Method: We used histological stains, immunohistochemistry and biochemical means to determine changes in the visceral adipose tissue from WT and db/db mice. Moreover, similar techniques were used in 3xTg-AD mice that received white fat pads from WT and db/db donors to determine any changes in amyloid and tau pathology. Result: Our study shows that recipient 3xTg-AD mice from db/db fat pads mice develop profound changes in tau pathology due to increased CDK5 expression compared to 3xTg-AD mice that received fad pads from WT mice. This increment in tau level was associated with elevated levels in IL-1β and profound microglia activation. Moreover, we found the opposite effect on amyloid pathology, in which insoluble Aβ levels and Thioflavin positive plaques were reduced in recipient 3xTg-AD mice from db/db fat pads compared to 3xTg-AD mice that received fad pads from WT mice. These reduction in Aβ levels were correlated with an increment in microglia phagocytic capacity. Conclusion: Overall, our study demonstrate a novel important crosstalk between Alzheimer´s disease and obesity/diabetes type II through visceral adipose cells and a differential effect on tau and Aβ pathology mediated by an activated immune response.This study was supported by Minister of Science and Innovation grant PID2019-108911RA-100 (D.B.V.), Alzheimer's Association grant AARG-22-9282/9, Beatriz Galindo program BAGAL18/00052 (D.B.V.), University of Malaga grant PPIT.UMA.B1- 2021_32(LTE) and Institute of Health Carlos III (ISCiii) grant PI18/01557 (A.G.) cofinanced by FEDER funds from European Union

Visceral adipose tissue triggers tau pathogenesis in transgenic mice through CDK5/P25 pathway.

Alzheimer’s disease (AD) is a complex disorder and multiple molecular mechanisms are involved in AD onset and progression. Recent evidences have suggested that metabolic alterations are an important pathological feature in this disease progression. Likewise, diabetes and obesity, two mayor metabolic illnesses, are risk factors for AD. These two overwhelming diseases are associated with a significant expansion of visceral adipose tissue (VAT). Here, we hypothesize that the VAT may serve as a key communicator organ between the brain and peripheral metabolic illnesses and affecting both types of disorders. We used histological stains, immunohistochemistry and biochemical means to determine changes in the visceral adipose tissue from WT and db/db mice. Moreover, similar techniques were used in 3xTg-AD mice that received white fat pads from WT and db/db donors to determine any changes in amyloid and tau pathology. Our study shows that recipient 3xTg-AD mice from db/db mice fat pads develop profound changes in tau pathology due to increased CDK5 expression compared to 3xTg-AD mice that received fat pads from WT mice. This increment in tau level was associated with elevated levels in IL-1β and profound microglia activation. Moreover, we found the opposite effect on amyloid pathology, in which insoluble Aβ levels and Thioflavin positive plaques were reduced in recipient 3xTg-AD mice from db/db fat pads compared to 3xTg-AD mice that received fad pads from WT mice. These reduction in Aβ levels were correlated with an increment in microglia phagocytic capacity. Overall, our study demonstrate a novel important crosstalk between Alzheimer´s disease and obesity/diabetes type II through visceral adipose cells and a differential effect on tau and Aβ pathology mediated by an activated immune response.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Abatacept in patients with rheumatoid arthritis and interstitial lung disease: A national multicenter study of 63 patients

OBJECTIVE: Interstitial lung disease (ILD) is one of the most serious complications of rheumatoid arthritis (RA). In the present study, we aimed to assess the efficacy of abatacept (ABA) in patients with ILD associated to RA. METHODS: National multicenter, non-controlled, open-label registry study of RA patients with ILD treated with ABA. RESULTS: 63 patients (36 women) with RA-associated ILD undergoing ABA therapy were studied. The mean ± standard deviation age at the time of the study was 63.2 ± 9.8 years. The median duration of RA and ILD from diagnosis were 6.8 and 1 year, respectively. RA was seropositive in 55 patients (87.3%). In 15 (23.8%) of 63 patients the development of ILD was closely related to the administration of synthetic or biologic disease modifying anti-rheumatic drugs. After a follow-up of 9.4 ± 3.2 months, two-thirds of patients remained stable whereas one-quarter experienced improvement in the Modified Medical Research Council scale. At that time forced vital capacity remained stable in almost two-thirds of patents and improved in one out of five patients assessed. Also, diffusing capacity of the lung for carbon monoxide remained stable in almost two-thirds and showed improvement in a quarter of the patients assessed. At 12 months, 50% of the 22 patients in whom chest HRCT scan was performed due persistence of respiratory symptoms showed stabilization, 8 (36.4%) improvement and 3 worsening of the HRCT scan pattern. Eleven of 63 patients had to discontinue ABA, mainly due to adverse events. CONCLUSION: ABA appears to be an effective in RA-associated ILD.Funding: This work was partially supported by RETICS Programs, RD08/0075 (RIER) and RD12/0009/0013 from ‘‘Instituto de Salud Carlos III’’ (ISCIII), Spain