Voluntary exercise increases cholesterol efflux but not macrophage reverse cholesterol transport in vivo in mice

Physical exercise beneficially impacts on the plasma lipoprotein profile as well as on the incidence of cardiovascular events and is therefore recommended in primary and secondary prevention strategies against atherosclerotic cardiovascular disease. However, the underlying mechanisms of the protective effect of exercise remain largely unknown. Therefore, the present study tested the hypothesis that voluntary exercise in mice impacts on cholesterol efflux and in vivo reverse cholesterol transport (RCT). After two weeks of voluntary wheel running (average 10.1 ± 1.4 km/day) plasma triglycerides were lower (p < 0.05), while otherwise lipid and lipoprotein levels did not change. Macrophage cholesterol efflux towards plasma was significantly increased in running (n = 8) compared to sedentary (n = 6) mice (14.93 ± 1.40 vs. 12.33 ± 2.60%, p < 0.05). In addition, fecal excretion of bile acids (3.86 ± 0.50 vs. 2.90 ± 0.51 nmol/d, p = 0.001) and neutral sterols (2.75 ± 0.43 vs. 1.94 ± 0.22 nmol/d, p < 0.01) was significantly higher in running mice. However, RCT from macrophages to feces remained essentially unchanged in running mice compared with sedentary controls (bile acids: 3.2 ± 1.0 vs. 2.9 ± 1.1 % of injected dose, n.s.; neutral sterols: 1.4 ± 0.7 vs. 1.1 ± 0.5 % injected dose, n.s.). Judged by the plasma lathosterol to cholesterol ratio, endogenous cholesterol synthesis was increased in exercising mice (0.15 ± 0.03 vs. 0.11 ± 0.02, p < 0.05), while the hepatic mRNA expression of key transporters for biliary cholesterol (Abcg5/g8, Sr-bI) as well as bile acid (Abcb11) and phospholipd (Abcb4) excretion did not change. These data indicate that the beneficial effects of exercise on cardiovascular health include increased cholesterol efflux, but do not extend to other components of RCT. The increased fecal cholesterol excretion observed in running mice is likely explained by higher endogenous cholesterol synthesis, however, it does not reflect increased RCT in the face of unchanged expression of key transporters for biliary sterol secretion

Integration of Productmodel Databases into Multi-Agent Systems

This paper deals with two different agent-based approaches aimed at the incorporation of complex design information into multi-agent planning systems. The first system facilitates collaborative structural design processes, the second one supports fire engineering in buildings. Both approaches are part of two different research projects that belong to the DFG1 priority program 1103 entitled “Network-based Co-operative Planning Processes in Structural Engineering“ (DFG 2000). The two approaches provide similar database wrapper agents to integrate relevant design information into two multi-agent systems: Database wrapper agents make the relevant product model data usable for further agents in the multi-agent system, independent on their physical location. Thus, database wrapper agents act as an interface between multi-agent system and heterogeneous database systems. The communication between the database wrapper agents and other requesting agents presumes a common vocabulary: a specific database ontology that maps database related message contents into database objects. Hereby, the software-wrapping technology enables the various design experts to plug in existing database systems and data resources into a specific multi-agent system easily. As a consequence, dynamic changes in the design information of large collaborative engineering projects are adequately supported. The flexible architecture of the database wrapper agent concept is demonstrated by the integration of an XML and a relational database system

Abstraction of Process Relevant Information from Geotechnical Standards and Regulations

The paper presents the abstraction of process relevant information in order to enable the workflow management based on semantic data. It is shown for three examples, how the standards define the information needed to perform a certain planning activity. Abstraction of process relevant information is discussed for different granularities of the underlying processmodel. As one possible application ProMiSE is introduced, which uses process relevant data in individual tokens in a petri-net based process-model

Backing collisions: a study of drivers\u27 eye and backing behaviour using combined rear-view camera and sensor systems

Context—Backing crash injures can be severe; approximately 200 of the 2,500 reported injuries of this type per year to children under the age of 15 years result in death. Technology for assisting drivers when backing has limited success in preventing backing crashes. Objectives—Two questions are addressed: Why is the reduction in backing crashes moderate when rear-view cameras are deployed? Could rear-view cameras augment sensor systems? Design—46 drivers (36 experimental, 10 control) completed 16 parking trials over 2 days (eight trials per day). Experimental participants were provided with a sensor camera system, controls were not. Three crash scenarios were introduced. Setting—Parking facility at UMass Amherst, USA. Subjects—46 drivers (33 men, 13 women) average age 29 years, who were Massachusetts residents licensed within the USA for an average of 9.3 years. Interventions—Vehicles equipped with a rear-view camera and sensor system-based parking aid. Main Outcome Measures—Subject’s eye fixations while driving and researcher’s observation of collision with objects during backing. Results—Only 20% of drivers looked at the rear-view camera before backing, and 88% of those did not crash. Of those who did not look at the rear-view camera before backing, 46% looked after the sensor warned the driver. Conclusions—This study indicates that drivers not only attend to an audible warning, but will look at a rear-view camera if available. Evidence suggests that when used appropriately, rear-view cameras can mitigate the occurrence of backing crashes, particularly when paired with an appropriate sensor system

The Resource Curse and Rentier States in the Caspian Region : A Need for Context Analysis

Although much attention is paid to the Caspian region with regard to energy issues, the domestic consequences of the region’s resource production have so far constituted a neglected field of research. A systematic survey of the latest research trends in the economic and political causalities of the resource curse and of rentier states reveals that there is a need for context analysis. In reference to this, the paper traces any shortcomings and promising approaches in the existent body of literature on the Caspian region. Following on from this, the paper then proposes a new approach; specifically, one in which any differences and similarities in the context conditions are captured. This enables a more precise exploration of the exact ways in which they form contemporary post-Soviet Caspian rentier states.Obwohl der Region am Kaspischen Meer im Zuge von Energiediskursen große Aufmerksamkeit zuteil wird, stellen die innerstaatlichen Folgen der Ressourcenproduktion in der Region ein bislang vernachlässigtes Forschungsfeld dar. Ein systematischer Überblick über die jüngsten Forschungstrends zu wirtschaftlichen und politischen Kausalzusammenhängen des Ressourcenfluchs und zu Rentierstaaten offenbart die Notwendigkeit von Kontextanalysen. Hierauf Bezug nehmend, analysiert der Aufsatz sowohl die Mängel als auch viel versprechende Ansätze in der betreffenden Literatur zur Region am Kaspischen Meer. Der Aufsatz stellt letztendlich einen neuen Ansatz vor, der Unterschiede und Gemeinsamkeiten in den Kontextbedingungen erfasst, um zu erforschen, wie diese die gegenwärtigen post-sowjetischen Rentierstaaten in der Region am Kaspischen Meer tatsächlich prägen

2.b Faith and Politics in Germany - A Glass Half Full

Rev. Meissner explains the challenges to Christianity in Germany today and that these challenges are not new to Christianity

2.d Session Two Q & A

President Harrison and Rev. Meissner\u27s answer questions from the audience about the church today in Germany and the United States