A measurement of the attenuation of radiation from F-18 by a PET/MR scanner

This is the peer reviewed version of the following article: Wendt, R.E., III, Ai, H.A., Meier, J.G., Lopez, B.P., Fahrenholtz, S.J. and Mawlawi, O.R. (2018), A measurement of the attenuation of radiation from F-18 by a PET/MR scanner. J Appl Clin Med Phys, 19: 336-340. , which has been published in final form at https://doi.org/10.1002/acm2.12479. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.https://openworks.mdanderson.org/mdacc_imgphys_pubs/1004/thumbnail.jp

The (1+1)-dimensional Massive sine-Gordon Field Theory and the Gaussian Wave-functional Approach

The ground, one- and two-particle states of the (1+1)-dimensional massive sine-Gordon field theory are investigated within the framework of the Gaussian wave-functional approach. We demonstrate that for a certain region of the model-parameter space, the vacuum of the field system is asymmetrical. Furthermore, it is shown that two-particle bound state can exist upon the asymmetric vacuum for a part of the aforementioned region. Besides, for the bosonic equivalent to the massive Schwinger model, the masses of the one boson and two-boson bound states agree with the recent second-order results of a fermion-mass perturbation calculation when the fermion mass is small.Comment: Latex, 11 pages, 8 figures (EPS files

Photonic mode dispersion of a two-dimensional distributed feedback polymer laser

G. A. Turnbull, P. Andrew, William L. Barnes, and I. D. W. Samuel, Physical Review B, Vol. 67, article 165107 (2003). "Copyright © 2003 by the American Physical Society."We present an analysis of the photonic mode dispersion of a two-dimensional (2D) distributed feedback polymer laser based on the conjugated polymer poly[2-methoxy-5-(2′-ethylhexyloxy)-1,4-phenylene vinylene]. We use a combination of a simple model, together with experimental measurements of the photonic mode dispersion in transmission and emission, to explain the operating characteristics of the laser. The laser was found to oscillate at 636 nm on one edge of a photonic stop band in the photonic dispersion. A 2D coupling of modes traveling perpendicular to the orthogonal gratings was found to lead to a low divergence laser emission normal to the waveguide. At pump energies well above the oscillation threshold for this mode, a divergent, cross-shaped far-field emission was observed, resulting from a distributed feedback occurring over a wide range of wave vectors in one band of the photonic dispersion

Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity

Chemotherapeutics for the treatment of tumorigenic conditions that feature novel modes of action are highly sought after to overcome the limitations of current chemotherapies. Herein, we report the conjugation of the alkylating agent chlorambucil to the RAPTA scaffold, a well-established pharmacophore. While chlorambucil is known to alkylate DNA, the RAPTA complexes are known to coordinate to amino acid side chains of proteins. Therefore, such a molecule combines DNA and protein targeting properties in a single molecule. Several chlorambucil-tethered RAPTA derivatives were prepared and tested for their cytotoxicity, stability in water and reactivity to protein and DNA substrates. The anticancer activity of the complexes is widely driven by the cytotoxicity of the chlorambucil moiety. However, especially in the cis-platin-resistant A2780R cells, the chlorambucil-functionalized RAPTA derivatives are in general more cytotoxic than chlorambucil and also a mixture of chlorambucil and the parent organoruthenium RAPTA compound. In a proof-of-principle experiment, the cross-linking of DNA and protein fragments by a chlorambucil-RAPTA derivative was observed

Racial or Ethnic and Socioeconomic Inequalities in Adherence to National Dietary Guidance in a Large Cohort of US Pregnant Women

BACKGROUND: The significance of periconceptional nutrition for optimizing offspring and maternal health and reducing social inequalities warrants greater understanding of diet quality among US women. OBJECTIVE: Our objective was to evaluate racial or ethnic and education inequalities in periconceptional diet quality and sources of energy and micronutrients. DESIGN: Cross-sectional analysis of data from the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be cohort. PARTICIPANTS AND SETTING: Nulliparous women (N=7,511) were enrolled across eight US medical centers from 2010 to 2013. MAIN OUTCOME MEASURES: A semiquantitative food frequency questionnaire assessing usual dietary intake during the 3 months around conception was self-administered during the first trimester. Diet quality, measured using the Healthy Eating Index-2010 (HEI-2010), and sources of energy and micronutrients were the outcomes. STATISTICAL ANALYSES: Differences in diet quality were tested across maternal racial or ethnic and education groups using F tests associated with analysis of variance and χ2 tests. RESULTS: HEI-2010 score increased with higher education, but the increase among non-Hispanic black women was smaller than among non-Hispanic whites and Hispanics (interaction P value <0.0001). For all groups, average scores for HEI-2010 components were below recommendations. Top sources of energy were sugar-sweetened beverages, pasta dishes, and grain desserts, but sources varied by race or ethnicity and education. Approximately 34% of energy consumed was from empty calories (the sum of energy from added sugars, solid fats, and alcohol beyond moderate levels). The primary sources of iron, folate, and vitamin C were juices and enriched breads. CONCLUSIONS: Diet quality is suboptimal around conception, particularly among women who are non-Hispanic black, Hispanic, or who had less than a college degree. Diet quality could be improved by substituting intakes of refined grains and foods empty in calories with vegetables, peas and beans (legumes), seafood, and whole grains

Relationship between photonic band structure and emission characteristics of a polymer distributed feedback laser

G. A. Turnbull, P. Andrew, M. J. Jory, William L. Barnes, and I. D. W. Samuel, Physical Review B, Vol. 64, article 125122 (2001). "Copyright © 2001 by the American Physical Society."We present an experimental study of the emission characteristics and photonic band structure of a distributed feedback polymer laser, based on the material poly[2-methoxy-5-(2′-ethylhexyloxy)-1,4-phenylene vinylene]. We use measurements of the photonic band dispersion to explain how the substrate microstructure modifies both spontaneous and stimulated emission. The lasing structure exhibits a one-dimensional photonic band gap around 610 nm, with lasing occurring at one of the two associated band edges. The band edge (frequency) selection mechanism is found to be a difference in the level of output coupling of the modes associated with the two band edges. This is a feature of the second-order distributed feedback mechanism we have employed and is clearly evident in the measured photonic band structur