1,781 research outputs found
Are you getting sick? Predicting influenza-like symptoms using human mobility behaviors
Understanding and modeling the mobility of individuals is of paramount importance for public health. In particular, mobility characterization is key to predict the spatial and temporal diffusion of human-transmitted infections. However, the mobility behavior of a person can also reveal relevant information about her/his health conditions. In this paper, we study the impact of people mobility behaviors for predicting the future presence of flu-like and cold symptoms (i.e. fever, sore throat, cough, shortness of breath, headache, muscle pain, malaise, and cold). To this end, we use the mobility traces from mobile phones and the daily self-reported flu-like and cold symptoms of 29 individuals from February 20, 2013 to March 21, 2013. First of all, we demonstrate that daily symptoms of an individual can be predicted by using his/her mobility trace characteristics (e.g. total displacement, radius of gyration, number of unique visited places, etc.). Then, we present and validate models that are able to successfully predict the future presence of symptoms by analyzing the mobility patterns of our individuals. The proposed methodology could have a societal impact opening the way to customized mobile phone applications, which may detect and suggest to the user specific actions in order to prevent disease spreading and minimize the risk of contagion
Th-17 cell activation in response to high salt following acute kidney injury is associated with progressive fibrosis and attenuated by AT-1R antagonism
Exposure of rats to elevated dietary salt following recovery from acute kidney injury (AKI) accelerates the transition to chronic kidney disease (CKD), and is dependent on lymphocyte activity. Here we tested whether high salt diet triggers lymphocyte activation in postischemic kidneys to worsen renal inflammation and fibrosis. Male Sprague-Dawley rats on a 0.4% salt diet were subjected to left unilateral ischemia-reperfusion and allowed to recover for 5 weeks. This resulted in a mild elevation of CD4(+) T cells relative to sham animals. Contralateral unilateral nephrectomy and elevated dietary salt (4%) for 4 extra weeks hastened CKD and interstitial fibrosis. Activated T cells were increased in the kidney threefold after 4 weeks of elevated dietary salt exposure relative to post-AKI rats before salt feeding. The T cell subset was largely positive for IL-17, indicative of Th-17 cells. Because angiotensin II activity may influence lymphocyte activation, injured rats were given the AT1R antagonist, losartan, along with high salt diet. This significantly reduced the number of renal Th-17 cells to levels of sham rats, and significantly reduced the salt-induced increase in fibrosis to about half. In vitro studies in AKI-primed CD4(+) T cells indicated that angiotensin II and extracellular sodium enhanced, and losartan inhibited, IL-17 expression. Thus, dietary salt modulates immune cell activity in postischemic recovering kidneys because of the activity of local RAS, suggesting the participation of these cells in CKD progression post-AKI
Fast Algorithms For Josephson Junction Arrays : Bus--bars and Defects
We critically review the fast algorithms for the numerical study of
two--dimensional Josephson junction arrays and develop the analogy of such
systems with electrostatics. We extend these procedures to arrays with
bus--bars and defects in the form of missing bonds. The role of boundaries and
of the guage choice in determing the Green's function of the system is
clarified. The extension of the Green's function approach to other situations
is also discussed.Comment: Uuencoded 1 Revtex file (11 Pages), 3 Figures : Postscript Uuencode
Parametric Generation of Second Sound by First Sound in Superfluid Helium
We report the first experimental observation of parametric generation of
second sound (SS) by first sound (FS) in superfluid helium in a narrow
temperature range in the vicinity of . The temperature dependence
of the threshold FS amplitude is found to be in a good quantitative agreement
with the theory suggested long time ago and corrected for a finite geometry.
Strong amplitude fluctuations and two types of the SS spectra are observed
above the bifurcation. The latter effect is quantitatively explained by the
discreteness of the wave vector space and the strong temperature dependence of
the SS dissipation length.Comment: 4 pages, 4 postscript figures, REVTE
Low-Temperature Mobility of Surface Electrons and Ripplon-Phonon Interaction in Liquid Helium
The low-temperature dc mobility of the two-dimensional electron system
localized above the surface of superfluid helium is determined by the slowest
stage of the longitudinal momentum transfer to the bulk liquid, namely, by the
interaction of surface and volume excitations of liquid helium, which rapidly
decreases with temperature. Thus, the temperature dependence of the
low-frequency mobility is \mu_{dc} = 8.4x10^{-11}n_e T^{-20/3} cm^4 K^{20/3}/(V
s), where n_e is the surface electron density. The relation
T^{20/3}E_\perp^{-3} << 2x10^{-7} between the pressing electric field (in
kV/cm) and temperature (in K) and the value \omega < 10^8 T^5 K^{-5}s^{-1} of
the driving-field frequency have been obtained, at which the above effect can
be observed. In particular, E_\perp = 1 kV/cm corresponds to T < 70 mK and
\omega/2\pi < 30 Hz.Comment: 4 pages, 1 figur
Segue Between Favorable and Unfavorable Solvation
Solvation of small and large clusters are studied by simulation, considering
a range of solvent-solute attractive energy strengths. Over a wide range of
conditions, both for solvation in the Lennard-Jones liquid and in the SPC model
of water, it is shown that the mean solvent density varies linearly with
changes in solvent-solute adhesion or attractive energy strength. This behavior
is understood from the perspective of Weeks' theory of solvation [Ann. Rev.
Phys. Chem. 2002, 53, 533] and supports theories based upon that perspective.Comment: 8 pages, 7 figure
Large scale shell model calculations for odd-odd Mn isotopes
Large scale shell model calculations have been carried out for odd-odd
Mn isotopes in two different model spaces. First set of calculations
have been carried out in full shell valence space with two recently
derived shell interactions namely GXPF1A and KB3G treating Ca
as core. The second set of calculations have been performed in
valence space with the interaction treating Ca as core and
imposing a truncation by allowing up to a total of six particle excitations
from the 0f orbital to the upper orbitals for protons and
from the upper orbitals to the 0g orbital for neutron. For
low-lying states in Mn, the KB3G and GXPF1A both predicts good results
and for Mn, KB3G is much better than GXPF1A. For negative parity and
high-spin positive parity states in both isotopes interaction is
required. Experimental data on Mn is sparse and therefore it is not
possible to make any definite conclusions. More experimental data on negative
parity states is needed to ascertain the importance of 0g and higher
orbitals in neutron rich Mn isotopes.Comment: 5 pages, 4 figures, Submitted to Eur. Phys. J.
A Multifaceted Mathematical Approach for Complex Systems
Applied mathematics has an important role to play in developing the tools needed for the analysis, simulation, and optimization of complex problems. These efforts require the development of the mathematical foundations for scientific discovery, engineering design, and risk analysis based on a sound integrated approach for the understanding of complex systems. However, maximizing the impact of applied mathematics on these challenges requires a novel perspective on approaching the mathematical enterprise. Previous reports that have surveyed the DOE's research needs in applied mathematics have played a key role in defining research directions with the community. Although these reports have had significant impact, accurately assessing current research needs requires an evaluation of today's challenges against the backdrop of recent advances in applied mathematics and computing. To address these needs, the DOE Applied Mathematics Program sponsored a Workshop for Mathematics for the Analysis, Simulation and Optimization of Complex Systems on September 13-14, 2011. The workshop had approximately 50 participants from both the national labs and academia. The goal of the workshop was to identify new research areas in applied mathematics that will complement and enhance the existing DOE ASCR Applied Mathematics Program efforts that are needed to address problems associated with complex systems. This report describes recommendations from the workshop and subsequent analysis of the workshop findings by the organizing committee
Magneto-shear modes and a.c. dissipation in a two-dimensional Wigner crystal
The a.c. response of an unpinned and finite 2D Wigner crystal to electric
fields at an angular frequency has been calculated in the dissipative
limit, , where is the scattering rate. For
electrons screened by parallel electrodes, in zero magnetic field the
long-wavelength excitations are a diffusive longitudinal transmission line mode
and a diffusive shear mode. A magnetic field couples these modes together to
form two new magneto-shear modes. The dimensionless coupling parameter where and are the
speeds of transverse and longitudinal sound in the collisionless limit and
and are the tensor components of the
magnetoconductivity. For , both the coupled modes contribute
to the response of 2D electrons in a Corbino disk measurement of
magnetoconductivity. For , the electron crystal rotates rigidly in
a magnetic field. In general, both the amplitude and phase of the measured a.c.
currents are changed by the shear modulus. In principle, both the
magnetoconductivity and the shear modulus can be measured simultaneously.Comment: REVTeX, 7 pp., 4 eps figure
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