Our Experiences in Acute Arterial Embolism Treatment with Endovascular Techniques in Lower Extremity

Objectives: The study aims to retrospectively evaluate the 1-year results of endovascular treatment with rheolytic thrombectomy(TR) or catheter-directed thrombolytic(CDT) infusion therapy in acute femoro-popliteal bypass graft occlusion. Methods: The patients who had a history of femoro-popliteal by-pass operation and during their follow-up diagnosed with ipsilateral acute limb ischemia between 2016 and 2018 were included. The total of 13 patients were included and they were divided into two groups according to their treatment methods (RT, n=8 vs CDT, n=5). Results: There was no statistically significant difference between the two groups in terms of demographic data and Rutherford embolism classification. Reolitic thrombectomy and catheter-directed thromolytic infusion primary patency values were 87.5% and 80% for 6 months, 75% and 60% for 12 months, respectively. Secondary patency values were found to be 100% in both groups for 6 months, and 87.5% and 80% for 12 months, respectively. There was no significant difference between the two groups in terms of primer and sekonder patency. Conclusion:Endovascular therapy can be preferred in the treatment of acute femoro-popliteal by-pass graft occlusion in selected patient groups due to its less invasiveness, early mobilization, and low mortality and morbidity rates compared to surgery

A necessary condition to keep in mind after blunt trauma: cardiac tamponade

Kardiyak travmalar torasik travmaların yaklaşık %1'ini oluşturmaktadır. Kardiyak yaralanmalar künt veya penetran yaralanmalar şeklinde karşımıza çıkabilir. Bu yaralanmalarda tanı ve tedavi süreci ne kadar hızlı olursa, mortalite de o kadar düşük olmaktadır. Bu hastalarda dikkatli fizik muayene ve gerekiyor ise ekokardiyografiden faydalanılarak kardiyak yaralanma tanısının erken koyulması ve cerrahi girişimin planlanması mortalite ve morbidite açısından önemlidir. Aynı zamanda farklı klinikler arasında hasta hakkında doğru bilgilendirme yapılarak hekimler arasında koordinasyon kurulması, buna göre gerekli hazırlıkların yapılarak cerrahiye giden süreçte vakit kaybının önlenmesi, hastanın hayatını kurtaran en önemli davranış olmuştur. Bu olgumuzda motorsiklet kazası sonucu acil servise kabul edilmiş ve kardiyak tamponat tanısı almış 22 yaşında erkek hastayı literature katkı sağlaması açısından sunduk.Cardiac injuries represent 1% of the thoracic traumas. Cardiac injuries can be presented as blunt or penetrating injuries. In these patients, most important factors in determining the mortality are diagnosis and treatment process. Patients with cardiac tamponade due to blunt trauma can benefit from careful physical and echocardiographic examination. In addition; communication between different centers, giving correct data about the patient, establishing coordination among physicians and making necessary preparations for surgery can prevent loss of time. In this case report we present a 22year-old male patient who was brought to emergency service after motorcycle accident and diagnosed with cardiac tamponade

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

Microvesicles (MVs) play an important role in intercellular communication by carrying mRNAs, microRNAs (miRNAs), non-coding RNAs, proteins, and DNA from cell to cell. To our knowledge, this is the first report of delivery of a therapeutic mRNA/protein via MVs for treatment of cancer. We first generated genetically engineered MVs by expressing high levels of the suicide gene mRNA and protein–cytosine deaminase (CD) fused to uracil phosphoribosyltransferase (UPRT) in MV donor cells. MVs were isolated from these cells and used to treat pre-established nerve sheath tumors (schwannomas) in an orthotopic mouse model. We demonstrated that MV-mediated delivery of CD-UPRT mRNA/protein by direct injection into schwannomas led to regression of these tumors upon systemic treatment with the prodrug (5-fluorocytosine (5-FC)), which is converted within tumor cells to 5-fluorouracil (5-FU)–an anticancer agent. Taken together, these studies suggest that MVs can serve as novel cell-derived “liposomes” to effectively deliver therapeutic mRNA/proteins to treatment of diseases

Monophasic synovial sarcoma of the pharynx: a case report

Synovial sarcomas are a rare form of soft tissue sarcomas. We present a case of a 62 year-old male presenting with a left thyroid lump initially though to be a thyroid adenoma but subsequently diagnosed as a monophasic synovial sarcoma of the pharynx. We discuss the diagnosis and treatment of this case