Investigation of Erosion Corrosion Caused by Drinking Water in the Faucet with Computational Fluid Dynamics

In this study, the reason for erosion-corrosion of drinking or mains water in the faucet was investigated by computational fluid dynamics. Pipes used in homes, the service sector, and industry are responsible for transporting different types of fluids from one place to another. Considering the faucet design, the SolidWorks program was used for 3D studies. In-faucet flow analyses were performed using Ansys Fluent, a computational fluid dynamics program based on the finite volume method. In the analyses, lime particles were chosen. At the end of the analysis, the amount of erosion in the faucet was obtained

Peroxisome proliferators-activated alpha agonist treatment ameliorates hepatic damage in rats with obstructive jaundice: an experimental study

<p>Abstract</p> <p>Background</p> <p>Peroxisome proliferators-activated receptor alpha (PPARα) activation modulates cholesterol metabolism and suppresses bile acid synthesis. This study aims to evaluate the effect of short-term administration of fenofibrate, a PPARα agonist, on proinflammatory cytokines, apoptosis, and hepatocellular damage in cholestasis.</p> <p>Methods</p> <p>Forty male Wistar rats were randomly divided into four groups: I = sham operated, II = bile duct ligation (BDL), III = BDL + vehicle (gum Arabic), IV = BDL + fenofibrate (100 mg/kg/day). All rats were sacrificed on 7^thday after obtaining blood samples and liver tissue. Total bilirubin, aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), gamma-glutamyl transferase, (GGT), tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1 β), and total bile acid (TBA) in serum, and liver damage scores; portal inflammation, necrosis, bile duct number, in liver tissue were evaluated. Apoptosis in liver was also assessed by immunohistochemical staining.</p> <p>Results</p> <p>Fenofibrate administration significantly reduced serum total bilirubin, AST, ALT, ALP, and GGT, TNF-α, IL-1 β levels, and TBA (<it>P </it>< 0.01). Hepatic portal inflammation, hepatic necrosis, number of the bile ducts and apoptosis in rats with BDL were more prominent than the sham-operated animals (<it>P </it>< 0.01). PPARα induction improved all histopathologic parameters (<it>P </it>< 0.01), except for the number of the bile duct, which was markedly increased by fenofibrate therapy (<it>P </it>< 0.01).</p> <p>Conclusion</p> <p>Short-term administration of fenofibrate to the BDL rats exerts beneficial effects on hepatocellular damage and apoptosis.</p

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Computational fluid dynamics simulation of erosion-corrosion in abrasive water jet machining

Today, conventional machining with chip or machining without chip machining manufacturing methods is used to bring to the desired dimensions sizes the machines and equipment used in the industry. However, non-traditional manufacturing methods are used in cases where traditional machining manufacturing methods are inadequate. Cutting with water jet which is one of the non-traditional manufacturing methods is commonly used in several fields of industry. Unlike traditional manufacturing methods such as turning and milling, not using of a physical cutting tool is among the advantages of the method. Abrasive water jet manufacturing method was started to be applied by adding abrasive particles in the water jet. Apart from the superior properties of the method, possible damages occur in the water jet nozzle due to processes such as cutting or drilling by applying high pressure. Erosion-corrosion is the leading damage among these damages. In this study, the erosion-corrosion in the nozzle caused by high-pressure water and abrasive during the abrasive water jet cutting process was simulated in the computer environment. In this paper, the erosion rate in the nozzle was calculated as 6,90E-06 kg/m(2) s. This value was converted as 0,30 mm (27,09 mm for yearly) via developed software for 100 h

Drop test simulation and surrogate-based optimization of a dishwasher mechanical structure and its packaging module

A drop test simulation of the mechanical structure of a redesigned dishwasher is performed by using a detailed finite element (FE) model. The nonlinear explicit FE code LS-DYNAA (R) is used for the drop impact simulations. The FE model is validated through real tests of two drop scenarios (vertical and inclined to the side). An optimization study is performed in order to determine the optimum design variables for better crash performance. The effects of geometric parameters and material properties on the weights of certain components (ie, dogleg plate and bottom foam) are investigated. A surrogate-based optimization approach is used to find optimum values for the dogleg plate thickness, bottom foam density and increment of the bottom foam height to minimize the weights of both components. Two different surrogate models are used to predict optimization problem constraints that have a crucial role in the crash performance of the dishwasher mechanical structure and packaging module: the polynomial response surface and radial basis functions. The results showed that the dogleg plate mass can be slightly reduced and the bottom foam mass can be significantly reduced in order to obtain the optimum dishwasher configuration and better crashworthiness. The weights of the dogleg plate and bottom foam could be lowered by as much as 5.95 and 24.8 %, respectively. Finally, multi-objective optimization is performed by minimizing a composite objective function that provides a compromise between the weights of both components. The results showed that weight reductions of 2.3 and 21.5 % could be obtained for the dogleg plate and bottom foam, respectively.This research was supported by TUBITAK (The Scientific and Technological Research Council of Turkey) and ARCELIK A.S. under the TEYDEB-1505 program (Project number: 5130016). The authors thank F. Ercin of ARCELIK A.S. for helping with the foam material model validation tests. The authors also thank M. Unlusoy and G.N. Naymanoglu of ARCELIK A.S. for their contributions to this study