10 research outputs found
Delineation of the Free-Floating Left Atrial Ball Mass with Real Time Three-Dimensional Transesophageal Echocardiography in a Patient with Mechanical Mitral Valve Prosthesis
Geleneksel ve İmplant destekli alt tam protezlerde alt çeneye gelen gerilmelerin sayısal yöntemle analizi
Protective Effects of Diospyros Kaki Leaves Extract against Oxidative Damage and Inflammation in the Testicular Ischemia-Reperfusion Model in Rats
Protective effect of Diospyros Kaki leaves extract against oxidative damage and inflammation in the testicular ischemia-reperfusion model were investigated in the study. 32 male rats were randomly and equally divided into 4 groups. While saline (SF) was given to the control and ischemia/reperfusion (I/R) groups for 5 days, Diospyros Kaki (DK) and I/R+DK were given 200 mg/kg of DK leaf extract. Afterwards, left orchiectomy was performed in control and DK, and testicular torsion was performed in I/R and I/R+DK for 2 hours. All rats were sacrificed 24 hours after procedures and samples were collected. Compared to the control, I/R had high MDA levels, low GSH and GSH-Px levels; compared to the I/R, MDA levels of the I/R+DK were lower, and the GSH and GSH-Px levels were higher. In I/R, the presence of congestion and hemorrhage were determined and the deterioration in seminiferous tubule structure and spermatogenesis were less in the I/R+DK. TNF-α, COX-2, BCL-2, and BAX genes expressions significantly lower in the I/R+DK. TNF-α and COX-2 proteins were higher in I/R and I/R+DK, while NRF2 was higher in I/R+DK. These results show DK leaves extract has crucial protective effect against oxidative damage and inflammation in the I/R model of rats.</p
Protective effect of Diospyros kaki L. leaves extract against oxidative damage and inflammation in the testicular ischemia-reperfusion model in rats
871-880The Oriental persimmon, Diospyros kaki L., native of China, with its bioactive compounds from leaves, flavonoids and
polyphenols in particular, possess antibacterial, antiallergic, anti-inflammatory, neuroprotective and antihypertensive
properties. Though, the anti-inflammatory and antioxidative effects of the D. kaki leaves have beneficial effects in I/R injury
in the brain, the same has not been investigated in testicular I/R injury until now. Hence, in the present study,
we investigated its leaf extract against oxidative damage and inflammation in the testicular ischemia-reperfusion model.
Thirty-two male rats were randomly and equally divided into four groups. While saline (SF) was given to the control and
ischemia/reperfusion (I/R) groups for 5 days, Diospyros kaki (DK) and I/R+DK were given 200 mg/kg of DK leaf extract.
Afterwards, left orchiectomy was performed in control and DK, and testicular torsion was performed in I/R and I/R+DK for
2 hours. All rats were sacrificed 24 hours after procedures and samples were collected. Compared to the control, I/R had
high MDA levels, low GSH and GSH-Px levels; compared to the I/R, MDA levels of the I/R+DK were lower, and the GSH
and GSH-Px levels were higher. In I/R, the presence of congestion and hemorrhage were determined and the deterioration in
seminiferous tubule structure and spermatogenesis were less in the I/R+DK. TNF-α, COX-2, BCL-2, and BAX genes
expressions were significantly lower in the I/R+DK group. TNF-α and COX-2 proteins were higher in I/R and I/R+DK
groups, while NRF2 was higher in I/R+DK. These results show that DK leaves extract has crucial protective effect against
oxidative damage and inflammation in the I/R model of rats