Schistosoma haematobium survey in a groupof rice production workers in theSamsun/Terme District

Amaç: Kontamine sular ile deri teması tarım işçilerinin sağlığı açısından önemli bir risk faktörüdür. Ülkemizde çeltik üretiminde çalışan işçilerde kontamine su aracılığıyla bulaşan şistozomiyazis taraması konusunda çalışma bulunmamaktadır. Bu çalışma çeltik tarlasında çalışan işçilerde schistosoma haemotobium varlığını saptamak amacıyla yapıldı. Yöntem: Samsun ili Terme ilçesindeki dokuz köyde yapılan saha çalışmasında araştırmaya katılan bireylerden alınan idrar örneği mikroskop altında schistosoma haemotobium yumurtalarının varlığı yönünden tarandı. Bulgular: Çalışmaya katılan 84 gönüllü bireyde yapılan taramada schistosoma haemotobium yumurtalarına rastlanmadı. Sonuç: Günümüzde tarım teknolojilerinin gelişmesinin, işçilerin etkenle temas riskini önleyerek şistozomiyazis insidansını düşürdüğü düşünülmektedir.Objective: Skin contact with contaminated water is an important risk factor for the health of agricultural workers. We could not found any study that has surveyed the transmission of schistosomiasis among rice production workers through contaminated water in Turkey. This study was examined the presence of schistosoma haematobium in rice production workers. Methods: Individuals who participated in the field study worked in nine villages of the Samsun/Terme district. We examined the urine samples of the participants under a microscope for evaluation of the presence of schistosoma haemotobium eggs . Results: There were 84 volunteers surveyed in this study. There was no schistosoma haemotobium eggs found in the urine samples surveyed. Conclusions: It is thought that developing agricultural technology reduces the incidence of schistosomiasis in workers by preventing the risk of contact with the agent

The prevalance of demodex species in faculty of health science students

WOS: 000369627900011Objective: Demodex folliculorum and D. brevis are acari that can be found in hair follicles and sebaceous glands of the skin, especially on face of human. This study was aimed to reveal prevalance of Demodex species in faculty of health science students. Methods: Skin surface biopsy was performed in subjects who completed socio-demographic questionnaire. The samples were examined under a microscope for demodex species. Results: In this study, at least one species of demodex was found to be positive in 47.4% of 270 students. Coexistence of D. folliculorum and D. brevis was observed in most of the subjects (50.8%). In all positive cases, the presence of only Demodex folliculorum or brevis was found in 29.7% and 19.5% respectively. There was no relationship between variables and demodex prevalence. Conclusion: This study showed that demodex species infestation is a common but an ignored health problem in faculty of health science students

Apelin-13 increased food intake with serum ghrelin and leptin levels in male rats

WOS: 000425181900010PubMed: 29405731In this study, we aimed to explain the role of apelin-13 on body weight, food and water intake with serum leptin, ghrelin, neuropeptid Y (NPY) and peptid YY (PYY) levels in male rat. Thirty-two Sprague-Dawley male rats were used for the study. The rats were injected SP (0.9 %) intraperitoneally (i.p) in the control group and 30 (AP30), 100 (AP100) and 300 (AP300) mu g/kg apelin-13 in the study groups, respectively, 10 min before the transition to dark period, for 10 days. During the experimental period, with light and dark periods of food and water intake, body weights were recorded in rats. Rats were euthanized and serum samples were obtained. In serum samples leptin, ghrelin, NPY and PYY levels were measured with specific ELISA kit. Apelin-13 was increased body weights in all three (AP30, AP100 and AP300) groups compared with the control group. AP100 and AP300 groups had increased food intake in the dark and the cumulative period, but in the light period food intake values were not significantly increased (p > 0.05). As for the value of water intake, compared with the control group, all dose of apelin-13 increased water intake during the dark and the cumulative period. There was no significant change in water intake in the light period. On the other hand, compared with the control group, serum leptin levels were found to increase in the groups administered 100 and 300 mu g/kg of apelin-13 (p 0.05). Apelin-13 increases body weight in rats as well as food and water intake (dark and cumulative period). Additionally, ghrelin can mediate the orexigenic effect of apelin-13 in the regulation of food intake (Fig. 4, Ref. 37).Karadeniz Technical University (KTU) scientific research Project Unit [1024]This project was supported by Karadeniz Technical University (KTU) scientific research Project Unit (Praje No 1024)

Effects of Apelin-13 administration on food and water intake in different photoperiod in male rats

No absract avalibale

Bee pollen increases hippocampal brain-derived neurotrophic factor and suppresses neuroinflammation in adult rats with chronic immobilization stress

Chronic stress is a potential problem associated with anxiety, depression, and cognitive dysfunction. Bee pollen, a powerful antioxidant, has many therapeutic effects. In this study, we aimed to examine the effects of one of the Anatolian bee pollens on depression/anxiety. 24 male Sprague Dawley rats were divided into 3 groups as control, stress, and bee pollen + stress. Bee pollen (200 mg/kg/day) was given to rats exposed to physical stress for 10 days. Open field test (OFT) and forced swimming test (FST) were applied to monitor the behavioral changes of the rats. After behavioral tests, the rats were euthanized. Brain-derived neurotrophic factor (BDNF), interleukin 1 beta (IL-1 beta), and tumor necrosis factor-alpha (TNF-alpha) levels were measured by ELISA to evaluate neurological and biochemical changes in rat hippocampal tissue. In addition, malondialdehyde (MDA) and glutathione (GSH) levels in the brain were evaluated. According to the behavioral test results, bee pollen reduced anxiety-like behavior but did not affect depression-like behavior. We also found that bee pollen suppressed neuroinflammation while reducing oxidative stress and lipid peroxidation in hippocampal tissues. Moreover, bee pollen significantly increased the level of BDNF in the hippocampus. In conclusion, bee pollen reduced oxidative damage and neuroinflammation caused by immobilization stress in rat brain tissue. Therefore, we suggest that bee pollen may be an effective natural compound in alleviating the negative effects caused by immobilization stress

Apelin-13 activates the hippocampal BDNF/TrkB signaling pathway and suppresses neuroinflammation in male rats with cisplatin-induced cognitive dysfunction

It has been established that cisplatin causes neuronal damage and cognitive impairment. However, the mechanism is not sufficiently clear. Apelin-13 is an endogenous peptide with strong neuroprotective effects through the synthesis of neurotrophic factors and suppression of inflammation. The aim of this study was to investigate the role of brain-derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) signaling pathway and the potential inhibitory effects of apelin-13 in the mechanism of cisplatin-induced hippocampal damage and cognitive impairment. Apelin-13 was administered to adult sprague dawley male rats at a dose of 20 nmol/kg every day for 4 weeks, cisplatin was administered at a dose of 5 mg/kg once a week for 4 weeks. The spatial and recognition memory tests of the rats were performed on the 5th week. BDNF and the inflammatory cytokines tumor necrosis factor-? (TNF-?) and interleukin-1? (IL-1?) levels were measured by ELISA in hippocampal homogenates. Pyramidal neuron and glial cell damage in the hippocampal CA1, CA3 and dentate gyrus (DG) were analyzed histologically. TrkB activity in the hippocampus was determined by immunohistochemical methods. Cisplatin impaired spatial and recognition memory in rats, while apelin-13 improved spatial memory but did not affect recognition memory. Cisplatin suppressed BDNF in the hippocampus while increased IL-1? and TNF-?. In contrast, apelin-13 administration increased BDNF but significantly suppressed TNF-? and IL-1B. Cisplatin caused pyramidal neuron and glial cell damage in CA1, CA3 and DG. In the cisplatin + apelin-13 group, however, pyramidal neuron and glial cell damage was less than those without apelin-13. Cisplatin increased TrkB activity in the hippocampus, which was counteracted by apelin-13. In conclusion, apelin-13 reduced the cisplatininduced cognitive deficiency, by suppressing inflammation and stimulating the synthesis and activation of neurotrophic factors in hippocampal tissue.Scientific Research Center of the Recep Tayyip Erdogan University TSA-2020-110

Anti-apoptotic and anti-oxidant effects of grape seed proanthocyanidin extract in preventing cyclosporine A-induced nephropathy

Aim: Although the pathogenesis of cyclosporine (CsA) nephropathy is not completely understood, it is attributed to oxidative damage and apoptosis. Grape seed proanthocyanidin extract (GSPE) is a molecule with antioxidant and anti-apoptotic properties. Our aim was to demonstrate the effects of GSPE in preventing CsA nephropathy