Awareness, attitude, and acceptability for abortion law among MTP seekers at a tertiary care center of east Delhi

Introduction: Termination of pregnancy has been prohibited by law in many countries, but in India induced abortion is legal, under the medical termination of pregnancy act (MTP) 1971. Despite the emergence of health services and availability of legal abortions, estimated 22 million abortions continue to be performed each year unsafely, resulting in the mortality of almost 47,000 women and morbidity for 5 million women due to ignorance amongst women. This study was done to evaluate the level of awareness, attitude and acceptability abortion law among MTP seekers at a tertiary care center. Materials and methods: Structured questionnaire-based interview schedules were used to assess the awareness, attitude, and acceptability of the MTP seekers. Results: About 95.4% and 31.6% have a vague idea about the gestational limit and indication for MTP. 87.8% had the preference for Government hospital only because of the “low cost of treatment”. 45.5% preferred only lady doctor and 83.6% felt that husband’s consent is mandatory for MTP. 13.7% of women were aware that it is legal under certain circumstances. Discussion: Women should be motivated to overcome socioeconomic and religious barriers and adopt effective contraception. Mass media should be made more informative and effective regarding safe abortion (gestational limit, person, place), usage of emergency contraception, mifepristone, and misoprostol for early abortion and discourage delay in decision making for MTP

Mild Sensory Stimulation Completely Protects the Adult Rodent Cortex from Ischemic Stroke

Despite progress in reducing ischemic stroke damage, complete protection remains elusive. Here we demonstrate that, after permanent occlusion of a major cortical artery (middle cerebral artery; MCA), single whisker stimulation can induce complete protection of the adult rat cortex, but only if administered within a critical time window. Animals that receive early treatment are histologically and behaviorally equivalent to healthy controls and have normal neuronal function. Protection of the cortex clearly requires reperfusion to the ischemic area despite permanent occlusion. Using blood flow imaging and other techniques we found evidence of reversed blood flow into MCA branches from an alternate arterial source via collateral vessels (inter-arterial connections), a potential mechanism for reperfusion. These findings suggest that the cortex is capable of extensive blood flow reorganization and more importantly that mild sensory stimulation can provide complete protection from impending stroke given early intervention. Such non-invasive, non-pharmacological intervention has clear translational potential

Guidelines for management of ischaemic stroke and transient ischaemic attack 2008

This article represents the update of the European Stroke Initiative Recommendations for Stroke Management. These guidelines cover both ischaemic stroke and transient ischaemic attacks, which are now considered to be a single entity. The article covers referral and emergency management, Stroke Unit service, diagnostics, primary and secondary prevention, general stroke treatment, specific treatment including acute management, management of complications, and rehabilitation

Telepsychiatry: Advancing Mental Health Support through Evolving Paradigms

Telemedicine has revolutionized the healthcare landscape, offering numerous advantages such as cost-effectiveness, convenience, and reduced infection risks.The editorial aims to highlight the potential concern of Telehealth in exacerbating psychiatric conditions.While telemedicine has its merits, the importance of in-person doctor-patient relationships cannot be understated. The bond formed in face-to-face settings fosters trust, empathy, and understanding, which are crucial in supporting patients during vulnerable moments. Limitations of tele-psychiatry, including the challenge of capturing non-verbal cues and prompt crisis management, are explored. Socioeconomic disparities, privacy issues, and limited access to reliable internet connections further add to the complexity of tele-psychiatric care. To enhance tele-psychiatry, hybrid models of care are proposed, combining in-person and telemedicine consultations to establish trust and maintain continuity of care. Innovative approaches, such as Good Psychiatric Management (GPM), Collaborative Assessment and Management of Suicidality (CAMS), and Mentalization- Based Therapy (MBT), have emerged, addressing the limitations of telemedicine. GPM's emphasis on closely monitoring patients' progress and incorporating psychopharmacological interventions and psychotherapy makes it well-suited for tele-psychiatry. CAMS stands out in crisis management, and MBT's focus on enhancing interpersonal skills is valuable in maintaining meaningful connections with patients. Telemedicine offers significant potential in psychiatry, but balancing medical advancements and preserving the human element of care is essential. Policymakers and healthcare professionals must prioritize establishing trusting relationships in face-to-face consultations while leveraging telemedicine for follow-up care. By skillfully integrating telemedicine and evidence-based treatment approaches, we can enhance patient outcomes and maintain the crucial human touch in mental health care

Prediction of BAP1 mutations in uveal melanoma patients from histology images using weakly supervised deep learning-based whole slide image analysis

AbstractWhile cases of uveal melanoma are relatively rare overall, it remains the most common intraocular cancer in adults and has a 10-year fatality rate of approximately 50% in metastatic patients with no effective treatment options. Mutations in BAP1, a tumor suppressor gene, have been previously found to be associated with the onset of metastasis in uveal melanoma patients. In this study, I utilize a weakly supervised deep learning-based pipeline in order to analyze whole slide images (WSIs) of uveal melanoma patients in conjunction with slide-level labels regarding the presence of BAP1 mutations. I demonstrate that there is a strong relationship between BAP1 mutations and physical tumor development in uveal melanoma and that my model is able to predict such relationships with an optimized mean test AUC of 0.86. My findings demonstrate that deep learning models are able to accurately predict patient-specific genotypic characteristics in uveal melanoma. Once integrated into and adapted to existing non-invasive ocular scanner technologies, my model would assist healthcare professionals in understanding the specific genetic profiles of their patients and provide more personalized treatment options in a safe, efficient manner, thus resulting in improved treatment outcomes.</jats:p

Telepsychiatry: Advancing Mental Health Support through Evolving Paradigms

Telemedicine has revolutionized the healthcare landscape, offering numerous advantages such as cost-effectiveness, convenience, and reduced infection risks. The editorial aims to highlight the potential concern of telehealth in exacerbating psychiatric conditions. While telemedicine has its merits, the importance of in-person doctor-patient relationships cannot be understated. The bond formed in face-to-face settings fosters trust, empathy, and understanding, which are crucial in supporting patients during vulnerable moments. Limitations of telepsychiatry, including the challenge of capturing non-verbal cues and prompt crisis management, are explored. Socioeconomic disparities, privacy issues, and limited access to reliable internet connections further add to the complexity of telepsychiatric care. To enhance telepsychiatry, hybrid models of care are proposed, combining in-person and telemedicine consultations to establish trust and maintain continuity of care. Innovative approaches, such as Good Psychiatric Management (GPM), Collaborative Assessment and Management of Suicidality (CAMS), and Mentalization-Based Therapy (MBT), have emerged, addressing the limitations of telemedicine. GPM's emphasis on closely monitoring patients' progress and incorporating psychopharmacological interventions and psychotherapy makes it well-suited for telepsychiatry. CAMS stands out in crisis management, and MBT's focus on enhancing interpersonal skills is valuable in maintaining meaningful connections with patients. Telemedicine offers significant potential in psychiatry, but balancing medical advancements and preserving the human element of care is essential. Policymakers and healthcare professionals must prioritize establishing trusting relationships in face-to-face consultations while leveraging telemedicine for follow-up care. By skillfully integrating telemedicine and evidence-based treatment approaches, we can enhance patient outcomes and maintain the crucial human touch in mental health care.https://psyarxiv.com/vua9x