30 research outputs found
Neglected vaginal pessary
Vaginal pessary may be opted for management of uterine prolapse as a safe option, but to avoid complications regular follow-up is a must. We are reporting a case of neglected vaginal pessary in a 72 year old female which got embedded in vaginal mucosa and required excision of vaginal band for its removal
Improved Capacity Image Steganography Algorithm using 16-Pixel Differencing with n-bit LSB Substitution for RGB Images
With the intrusion of internet into the lives of every household and terabytes of data being transmitted over the internet on daily basis, the protection of content being transmitted over the internet has become an extremely serious concern. Various measures and methods are being researched and devised everyday to ensure content protection of digital media. To address this issue of content protection, this paper proposes an RGB image steganography based on sixteen-pixel differencing with n-bit Least Significant Bit (LSB) substitution. The proposed technique provides higher embedding capacity without sacrificing the imperceptibility of the host data. The image is divided into 4×4 non overlapping blocks and in each block the average difference value is calculated. Based on this value the block is classified to fall into one of four levels such as, lower, lower-middle, higher-middle and higher. If block belongs to lower level then 2-bit LSB substitution is used in it. Similarly, for lower-middle, higher-middle and higher level blocks 3, 4, and 5 bit LSB substitution is used. In our proposed method there is no need of pixel value readjustment for minimizing distortion. The experimental results show that stego-images are imperceptible and have huge hiding capacity
Effect of glimepiride compared with glibenclamide on post prandial blood sugar in type II diabetes mellitus patients
Background: Diabetes mellitus is a major public health problem with many complications. The Global Burden of Diabetes Study has projected that there will be a 122% increase in the number of people with diabetes mellitus worldwide in 2025 compared to 1995. Despite the availability of new agents for the treatment of type 2 diabetes mellitus oral sulfonylureas remain a cornerstone of therapy.Glibenclamide and glimepiride are widely used sulfonylurea antidiabetic drugs.Methods: A randomized, open, parallel group study was conducted by the Department of Pharmacology in association with Department of Medicine at Maharishi Markandeshwar Institute of Medical Sciences & Research (MMIMSR), Mullana, Ambala. Total 50 patients were divided into two groups I & II. In Group I (n=25) glibenclamide (5-15 mg/day) & in Group II (n=25) glimepiride (1-6mg/day) was administered for a period of 24 weeks and data analyzed by Student’s “t”- test.Results: There was a significant improvement in the post prandial blood sugar score (p0.05) between the two groups.Conclusions: Both the drugs glibenclamide and glimepiride were effectively reduced post prandial blood sugar in both the groups. But these sulfonylurea drugs lowered post prandial blood sugar to a similar degree without significant difference between the two groups
Utjecaj fluorida proizvedenih aluminijskim industrijskim postrojenjem na biljke i područja nastanjena ljudima
Fluorine is a highly reactive common element that does not occur in nature in the elemental state. It exists in the form of fluorides and accounts for about 0.3 g/kg of the Earth’s crust. Generally, it is found in the form of a number of minerals like fluorspar, cryolite and fluor-apatite. Fluoride has both positive and negative effects on individual health. Fluoride, in the form of fluorspar and cryo- lite is distributed extensively in the lithosphere, and is renowned as the thir- teenth most common among elements in the earth’s crust. Hydrogen fluorides in gaseous form accumulate in the leaves of generally sensitive plants against a concentration gradient and therefore, considered as a most phytotoxic air pollut- ant and affects plants at extremely low concentration. As per our study, it is found that the fluoride impacts on fauna are in normal condition, but in coming times it may have adverse impact on fauna and flora of surroundings of Hindalco Industries Limited.Fluor je vrlo reaktivan element koji se u elementarnom obliku ne pojavljuje u prirodi. Postoji u obliku fluorida u zemljinoj kori, gdje se nalazi u omjeru od oko 0,3 g/kg. Općenito, nalazi se u obliku velikog broja minerala poput fluorita, kriolita i apatita. Fluorid ima i pozitivne i negativne učinke na ljudsko zdravlje. Fluorid, u obliku fluorita i kriolita, široko je rasprostranjen u litosferi, a poznat je i kao trinaesta najčešća tvar u Zemljinoj kori. Fluorovodici u plinovitom obliku nagomilavaju se u listovima uglavnom osjetljivih biljaka prema gradijentu koncentracije. Stoga se smatraju najfitotoksičnijim onečišćujućim tvarima u zraku, a djeluju na biljke i pri ekstremno niskim koncentracijama. Prema našoj studiji utvrđeno je da su učinci fluorida na faunu u uobičajenim okvirima, ali u budućnosti može imati štetan utjecaj na faunu i floru u okruženju tvornice Hindalco Industries Limited
FORMULATION AND EVALUATION OF LAMOTRIGINE BASED SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEM
Self-nanoemulsionof Lamotrigine (LMT), an anti-epileptic agent, having poor solubilty was formulated to improve the solubility and permeation. Co surfactant like Ethyl Oleate, Caprylate, Eucalyptus oil, Caprylic, Corn oil, Capmule, Fish oil, Coconut oil whereas PEG 400 and Propylene glycol to form the oil phase was selected as the oil. Seven trials were done using combination of sufactants/co-surfactants with oil phase . Trial H containing Caprylate as oil phase at Smix1:1(Tween20/PEG400, 1:1) proportion and trial I, the oil phase [Caprylate] composition was changed from Smix 1:1 to Smix (Tween20/PEG400, 1:2) formulated as SNEDDs and phase diagram shows 1:1 system is suitable for formulation . Aqueous dilution test shows that it is found for 3 hour gradually turbid on staying. Since it immediately dissolve the drug as a result of solubilisation effect of surfactant present in formulation. Stability study was carried out at 25o C/ 75 Rh. In this method no change in consistency, Colour or appearance has been observed. In vitro drug release was found to be identical in the formulations stored before after placed on stability. It appeared that the formulation of the selected batches kept on the stability test was found to be stable. In accelerated stability evaluation showed that Self nano-emulsion follows 1st order kinetic and found to be stabl
Highlighting the Compound Risk of COVID-19 and Environmental Pollutants Using Geospatial Technology
The new COVID-19 coronavirus disease has emerged as a global threat and not just to human health but also the global economy. Due to the pandemic, most countries affected have therefore imposed periods of full or partial lockdowns to restrict community transmission. This has had the welcome but unexpected side effect that existing levels of atmospheric pollutants, particularly in cities, have temporarily declined. As found by several authors, air quality can inherently exacerbate the risks linked to respiratory diseases, including COVID-19. In this study, we explore patterns of air pollution for ten of the most affected countries in the world, in the context of the 2020 development of the COVID-19 pandemic. We find that the concentrations of some of the principal atmospheric pollutants were temporarily reduced during the extensive lockdowns in the spring. Secondly, we show that the seasonality of the atmospheric pollutants is not significantly affected by these temporary changes, indicating that observed variations in COVID-19 conditions are likely to be linked to air quality. On this background, we confirm that air pollution may be a good predictor for the local and national severity of COVID-19 infections.The authors acknowledge financial support from the Spanish Government, Grant RTI2018-354 094336-B-I00 (MCIU/AEI/FEDER, UE), the Spanish Carlos III Health Institute, COV 20/01213, and the Basque Government, Grant IT1207-19
Effect of dietary tryptophan supplementation on growth, body composition and digestive enzymes activity of juvenile silver pompano Trachinotus blochii (Lacepede, 1801)
A 60-day feeding trial was conducted to study the effect of dietary supplementation of tryptophan in juvenile silver pompano
Trachinotus blochii (Lacepede, 1801) (Average initial weight=6.81±0.05 g). Five isonitrogenous and isolipidic feeds
supplemented with tryptophan at different levels, 0 (TRP0), 0.5 (TRP0.5), 1.0 (TRP1.0), 1.5 (TRP1.5) and 2.0 (TRP2.0) g 100 g-1
of diets were formulated. The weight gain%, specific growth rate, hepato-somatic index, digestives enzymes of stomach and
intestine except protease activity in stomach, red blood cells, white blood cells, crude protein, fat and ash content of the fish
were significantly influenced (p<0.05) by tryptophan supplementation. The viscero-somatic index, intraperitoneal fat ratio,
muscle ratio, protease activity in the stomach and acid insoluble ash were unaffected by the treatment. Best observations in
terms of growth, body composition and digestive enzyme activity among the treatments were obtained in the fish group fed
with tryptophan at a level of 0.5 g 100 g-1 feed. From the current observations it can be concluded that supplementation of
tryptophan at the rate of 0.5 g 100 g-1 diet can positively influence the growth of T. blochii