Colorectal Cancer Screening Education in Faith-Based Communities

The principal intent for colorectal cancer screening is early detection and primary prevention of colorectal cancer. In spite of these intentions, there is a reluctance of the general population to participate in screening. Colorectal cancer is preventable. However, screening non-adherence contributes to both cancer mortality and incidence rates and results in expensive, unnecessary health care costs. A faith-based community nurse-driven educational session, using an American Cancer Society PowerPoint, was developed to address barriers of screening non-adherence. The educational session was offered to adults who participate in multiple faith-based organizations. The session provided education regarding colorectal cancer and colorectal cancer screening and was delivered by an experienced faith community nurse. A pre-test/post-test design was utilized to evaluate if the educational session would increase the knowledge regarding colorectal cancer and colorectal cancer screening and decrease colorectal cancer screening perceived barriers. This research design also evaluated if intent to be screened increased with the educational session. Results indicated knowledge and intent to be screened increased and perceptions regarding embarrassment, pain, messiness and inconvenience of screenings decreased after the delivery of the educational session

Can physical joint simulators be used to anticipate clinical wear problems of new joint replacement implants prior to market release?

Medley, J. B. (2016). Can physical joint simulators be used to anticipate clinical wear problems of new joint replacement implants prior to market release? Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine, 230(5), 347–358. Copyright © 2016. Sage Publications. Reprinted by permission of SAGE Publications. https://doi.org/10.1177/0954411916643902One of the most important mandates of physical joint simulators is to provide test results that allow the implant manufacturer to anticipate and perhaps avoid clinical wear problems with their new products. This is best done before market release. This study gives four steps to follow in conducting such wear simulator testing. Two major examples involving hip wear simulators are discussed in which attempts had been made to predict clinical wear performance prior to market release. The second one, involving the DePuy ASR implant systems, is chosen for more extensive treatment by making it an illustrative example to explore whether wear simulator testing can anticipate clinical wear problems. It is concluded that hip wear simulator testing did provide data in the academic literature that indicated some risk of clinical wear problems prior to market release of the ASR implant systems. This supports the idea that physical joint simulators have an important role in the pre-market testing of new joint replacement implants

A new regional climate model for POLAR-CORDEX : evaluation of a 30-year hindcast with COSMO-CLM2 over Antarctica

Continent-wide climate information over the Antarctic Ice Sheet (AIS) is important to obtain accurate information of present climate and reduce uncertainties of the ice sheet mass balance response and resulting global sea level rise to future climate change. In this study, the COSMO-CLM2 Regional Climate Model is applied over the AIS and adapted for the specific meteorological and climatological conditions of the region. A 30-year hindcast was performed and evaluated against observational records consisting of long-term ground-based meteorological observations, automatic weather stations, radiosoundings, satellite records, stake measurements and ice cores. Reasonable agreement regarding the surface and upper-air climate is achieved by the COSMO-CLM2 model, comparable to the performance of other state-of-the-art climate models over the AIS. Meteorological variability of the surface climate is adequately simulated, and biases in the radiation and surface mass balance are small. The presented model therefore contributes as a new member to the COordinated Regional Downscaling EXperiment project over the AIS (POLAR-CORDEX) and the CORDEX-CORE initiative

Time to Scale Up Preexposure Prophylaxis Beyond the Highest-Risk Populations? Modeling Insights From High-Risk Women in Sub-Saharan Africa

OBJECTIVES: New HIV infections remain higher in women than men in sub-Saharan Africa. Preexposure prophylaxis (PrEP) is an effective HIV prevention measure, currently prioritized for those at highest risk, such as female sex workers (FSWs), for whom it is most cost-effective. However, the greatest number of HIV infections in sub-Saharan Africa occurs in women in the general population. As countries consider wider PrEP scale-up, there is a need to weigh the population-level impact, cost, and relative cost-effectiveness to inform priority setting. METHODS: We developed mathematical models of HIV risk to women and derived tools to highlight key considerations for PrEP programming. The models were fitted to South Africa, Zimbabwe, and Kenya, spanning a range of HIV burden in sub-Saharan Africa. The impact, cost, and cost-effectiveness of PrEP scale-up for adolescent girls and young women (AGYW), women 25 to 34 years old, and women 35 to 49 years old were assessed, accounting for differences in population sizes and the low program retention levels reported in demonstration projects. RESULTS: Preexposure prophylaxis could avert substantially more infections a year among women in general population than among FSW. The greatest number of infections could be averted annually among AGYW in South Africa (24-fold that for FSW). In Zimbabwe, the greatest number of infections could be averted among women 25 to 34 years old (8-fold that for FSW); and in Kenya, similarly between AGYW and women 25 to 34 years old (3-fold that for FSW). However, the unit costs of PrEP delivery for AGYW, women 25 to 34 years old, and women 35 to 49 years old would have to reduce considerably (by 70.8%-91.0% across scenarios) for scale-up to these populations to be as cost-effective as for FSW. CONCLUSIONS: Preexposure prophylaxis has the potential to substantially reduce new HIV infections in HIV-endemic countries in sub-Saharan Africa. This will necessitate PrEP being made widely available beyond those at highest individual risk and continued integration into a range of national services and at community level to significantly bring down the costs and improve cost-effectiveness

Antarctic firn compaction rates from repeat-track airborne radar data: I. Methods

While measurements of ice-sheet surface elevation change are increasingly used to assess mass change, the processes that control the elevation fluctuations not related to ice-flow dynamics (e.g. firn compaction and accumulation) remain difficult to measure. Here we use radar data from the Thwaites Glacier (West Antarctica) catchment to measure the rate of thickness change between horizons of constant age over different time intervals: 2009–10, 2010–11 and 2009–11. The average compaction rate to ∼25 m depth is 0.33 m a–1, with largest compaction rates near the surface. Our measurements indicate that the accumulation rate controls much of the spatio-temporal variations in the compaction rate while the role of temperature is unclear due to a lack of measurements. Based on a semi-empirical, steady-state densification model, we find that surveying older firn horizons minimizes the potential bias resulting from the variable depth of the constant age horizon. Our results suggest that the spatiotemporal variations in the firn compaction rate are an important consideration when converting surface elevation change to ice mass change. Compaction rates varied by up to 0.12 m a–1 over distances 20% larger during the 2010–11 interval than during 2009–10

An evaluation of a physics-based firn model and a semi-empirical firn model across the Greenland Ice Sheet (1980–2020)

The Greenland Ice Sheet's (GrIS) firn layer buffers the ice sheet's contribution to sea level rise by storing meltwater in its pore space. However, available pore space and meltwater retention capability is lost due to ablation of the firn layer and refreezing of meltwater as near-surface ice slabs in the firn. Understanding how firn properties respond to climate is important for constraining the GrIS's future contribution to sea level rise in a warming climate. Observations of firn density provide detailed information about firn properties, but they are spatially and temporally limited. Here we use two firn models, the physics-based SNOWPACK model and the Community Firn Model configured with a semi-empirical densification equation (CFM-GSFC), to quantify firn properties across the GrIS from 1980 through 2020. We use an identical forcing (Modern-Era Retrospective Analysis for Research and Applications, version 2 (MERRA-2) atmospheric reanalysis) for SNOWPACK and the CFM-GSFC in order to isolate firn model differences. To evaluate the models, we compare simulated firn properties, including firn air content (FAC), to measurements from the Surface Mass Balance and Snow on Sea Ice Working Group (SUMup) dataset of snow and firn density. Both models perform well (mean absolute percentage errors of 14 % in SNOWPACK and 16 % in the CFM-GSFC), though their performance is hindered by the spatial resolution of the atmospheric forcing. In the ice-sheet-wide simulations, the 1980–1995 average spatially integrated FAC (i.e., air volume in the firn) for the upper 100 m is 34 645 km3 from SNOWPACK and 28 581 km3 from the CFM-GSFC. The discrepancy in the magnitude of the modeled FAC stems from differences in densification with depth and variations in the sensitivity of the models to atmospheric forcing. In more recent years (2005–2020), both models simulate substantial depletion of pore space. During this period, the spatially integrated FAC across the entire GrIS decreases by 3.2 % (−66.6 km3 yr−1) in SNOWPACK and 1.5 % (−17.4 km3 yr−1) in the CFM-GSFC. These differing magnitudes demonstrate how model differences propagate throughout the FAC record. Over the full modeled record (1980–2020), SNOWPACK simulates a loss of pore space equivalent to 3 mm of sea level rise buffering, while the CFM-GSFC simulates a loss of 1 mm. The greatest depletion in FAC is along the margins and especially along the western margin where observations and models show the formation of near-surface, low-permeability ice slabs that may inhibit meltwater storage.</p

Raman Spectroscopy of Mott insulator states in optical lattices

We propose and analyse a Raman spectroscopy technique for probing the properties of quantum degenerate bosons in the ground band of an optical lattice. Our formalism describes excitations to higher vibrational bands and is valid for deep lattices where a tight-binding approach can be applied to the describe the initial state of the system. In sufficiently deep lattices, localized states in higher vibrational bands play an important role in the system response, and shifts in resonant frequency of excitation are sensitive to the number of particles per site. We present numerical results of this formalism applied to the case of a uniform lattice deep in the Mott insulator regime.Comment: 10 pages, 3 figure

Ice sheet record of recent sea-ice behavior and polynya variability in the Amundsen Sea, West Antarctica

Author Posting. © American Geophysical Union, 2013. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 118 (2013): 118–130, doi:10.1029/2012JC008077.Our understanding of past sea-ice variability is limited by the short length of satellite and instrumental records. Proxy records can extend these observations but require further development and validation. We compare methanesulfonic acid (MSA) and chloride (Cl–) concentrations from a new firn core from coastal West Antarctica with satellite-derived observations of regional sea-ice concentration (SIC) in the Amundsen Sea (AS) to evaluate spatial and temporal correlations from 2002–2010. The high accumulation rate (~39 g∙cm–2∙yr–1) provides monthly resolved records of MSA and Cl–, allowing detailed investigation of how regional SIC is recorded in the ice-sheet stratigraphy. Over the period 2002–2010 we find that the ice-sheet chemistry is significantly correlated with SIC variability within the AS and Pine Island Bay polynyas. Based on this result, we evaluate the use of ice-core chemistry as a proxy for interannual polynya variability in this region, one of the largest and most persistent polynya areas in Antarctica. MSA concentrations correlate strongly with summer SIC within the polynya regions, consistent with MSA at this site being derived from marine biological productivity during the spring and summer. Cl– concentrations correlate strongly with winter SIC within the polynyas as well as some regions outside the polynyas, consistent with Cl– at this site originating primarily from winter sea-ice formation. Spatial correlations were generally insignificant outside of the polynya areas, with some notable exceptions. Ice-core glaciochemical records from this dynamic region thus may provide a proxy for reconstructing AS and Pine Island Bay polynya variability prior to the satellite era.This research was supported by an award from the Department of Energy Office of Science Graduate Fellowship Program (DOE SCGF) to ASC, a James E. and Barbara V. Moltz Research Fellowship to SBD, and by grants from NSF-OPP (#ANT-0632031 & #ANT-0631973); NSF-MRI (#EAR-1126217); NASA Cryosphere Program (#NNX10AP09G); and a WHOI Andrew W. Mellon Foundation Award for Innovative Research.2013-07-2

Development of a Multilayer MODIS IST-Albedo Product of Greenland

A new multilayer IST-albedo Moderate Resolution Imaging Spectroradiometer (MODIS) product of Greenland was developed to meet the needs of the ice sheet modeling community. The multiple layers of the product enable the relationship between IST and albedo to be evaluated easily. Surface temperature is a fundamental input for dynamical ice sheet models because it is a component of the ice sheet radiation budget and mass balance. Albedo influences absorption of incoming solar radiation. The daily product will combine the existing standard MODIS Collection-6 ice-surface temperature, derived melt maps, snow albedo and water vapor products. The new product is available in a polar stereographic projection in NetCDF format. The product will ultimately extend from March 2000 through the end of 2017